業績紹介

Achivement

2013年業績

• Abe H, Hayes CN, Hiraga N, Imamura M, Tsuge M, Miki D, Takahashi S, Ochi H and Chayama K.

  A translational study of resistance emergence using sequential direct-acting antiviral agents for hepatitis C using ultra-deep sequencing.

  Am J Gastroenterol. 2013; 108: 1464-1472.

• Izumi N, Asahina Y, Kurosaki M, Yamada G, Kawai T, Kajiwara E, Okamura Y, Takeuchi T, Yokosuka O, Kariyama K, Toyoda J, Inao M, Tanaka E, Moriwaki H, Adachi H, Katsushima S, Kudo M, Takaguchi K, Hiasa Y, Chayama K, Yatsuhashi H, Oketani M and Kumada H.

  Inhibition of hepatocellular carcinoma by PegIFNalpha-2a in patients with chronic hepatitis C: a nationwide multicenter cooperative study.

  J Gastroenterol. 2013; 48: 382-390.

• Suzuki Y, Ikeda K, Suzuki F, Toyota J, Karino Y, Chayama K, Kawakami Y, Ishikawa H, Watanabe H, Hu W, Eley T, McPhee F, Hughes E and Kumada H.

  Dual oral therapy with daclatasvir and asunaprevir for patients with HCV genotype 1b infection and limited treatment options.

  J Hepatol. 2013; 58: 655-662.

• Karino Y, Toyota J, Ikeda K, Suzuki F, Chayama K, Kawakami Y, Ishikawa H, Watanabe H, Hernandez D, Yu F, McPhee F and Kumada H.

  Characterization of virologic escape in hepatitis C virus genotype 1b patients treated with the direct-acting antivirals daclatasvir and asunaprevir.

  J Hepatol. 2013; 58: 646-654.

• Hayashi N, Tanaka S, Kanao H, Oka S, Yoshida S and Chayama K.

  Relationship between narrow-band imaging magnifying observation and pit pattern diagnosis in colorectal tumors.

  Digestion. 2013; 87: 53-58.

• Lo PH, Urabe Y, Kumar V, Tanikawa C, Koike K, Kato N, Miki D, Chayama K, Kubo M, Nakamura Y and Matsuda K.

  Identification of a functional variant in the MICA promoter which regulates MICA expression and increases HCV-related hepatocellular carcinoma risk.

  PLoS One. 2013; 8: e61279.

• Lange CM, Miki D, Ochi H, Nischalke HD, Bojunga J, Bibert S, Morikawa K, Gouttenoire J, Cerny A, Dufour JF, Gorgievski-Hrisoho M, Heim MH, Malinverni R, Mullhaupt B, Negro F, Semela D, Kutalik Z, Muller T, Spengler U, Berg T, Chayama K, Moradpour D, Bochud PY, Hiroshima Liver Study G and Swiss Hepatitis CCSG.

  Genetic analyses reveal a role for vitamin D insufficiency in HCV-associated hepatocellular carcinoma development.

  PLoS One. 2013; 8: e64053.

• Hashiba M, Ono M, Hyogo H, Ikeda Y, Masuda K, Yoshioka R, Ishikawa Y, Nagata Y, Munekage K, Ochi T, Hirose A, Nozaki-Fujimura Y, Noguchi S, Okamoto N, Chayama K, Suganuma N and Saibara T.

  Glycemic variability is an independent predictive factor for development of hepatic fibrosis in nonalcoholic fatty liver disease.

  PLoS One. 2013; 8: e76161.

• Inoue T, Hyodo T, Murakami T, Takayama Y, Nishie A, Higaki A, Korenaga K, Sakamoto A, Osaki Y, Aikata H, Chayama K, Suda T, Takano T, Miyoshi K, Koda M, Numata K, Tanaka H, Iijima H, Ochi H, Hirooka M, Imai Y and Kudo M.

  Hypovascular hepatic nodules showing hypointense on the hepatobiliary-phase image of Gd-EOB-DTPA-enhanced MRI to develop a hypervascular hepatocellular carcinoma: a nationwide retrospective study on their natural course and risk factors.

  Dig Dis. 2013; 31: 472-479.

• Miki D, Ochi H, Takahashi A, Hayes CN, Urabe Y, Abe H, Kawaoka T, Tsuge M, Hiraga N, Imamura M, Kawakami Y, Aikata H, Takahashi S, Akuta N, Suzuki F, Ikeda K, Kumada H, Karino Y, Toyota J, Tsunoda T, Kubo M, Kamatani N, Nakamura Y and Chayama K.

  HLA-DQB1*03 confers susceptibility to chronic hepatitis C in Japanese: a genome-wide association study.

  PLoS One. 2013; 8: e84226.

• Sato A, Sata M, Ikeda K, Kumada T, Izumi N, Asahina Y, Osaki Y, Chayama K, Kaneko S, Sakai A, Onji M, Hiasa Y, Omura T, Ozeki I, Yokosuka O, Shiina S, Itsubo M, Nishiguchi S, Hirano K, Ide T, Sakisaka S, Yamasaki T, Hidaka I, Tanaka M, Kim SR and Ichida T.

  Clinical characteristics of patients who developed hepatocellular carcinoma after hepatitis C virus eradication with interferon therapy: current status in Japan.

  Intern Med. 2013; 52: 2701-2706.

• Watari I, Oka S, Tanaka S, Nakano M, Aoyama T, Yoshida S and Chayama K.

  Is Occult Obscure Gastrointestinal Bleeding a Definite Indication for Capsule Endoscopy? A Retrospective Analysis of Diagnostic Yield in Patients with Occult versus Overt Bleeding.

  Gastroenterol Res Pract. 2013; 2013: 915463.

• Fukuhara T, Kakizawa H, Aikata H, Tani C, Ishikawa M, Awai K and Chayama K.

  Usefulness of multi-detector row computed tomography for management of duodenal varices by emergency balloon-occluded retrograde transvenous obliteration.

  Clinical Journal of Gastroenterology. 2013; 6: 243-247.

• Hyogo H, Yamagishi S-i, Maeda S, Nakahara T, Kimura Y and Chayama K.

  sRAGE is associated with low waist circumference and Hb levels in NAFLD.

  Central European Journal of Medicine. 2013; 8: 830-834.

• Miyaki D, Aikata H, Kan H, Fujino H, Urabe A, Masaki K, Fukuhara T, Kobayashi T, Naeshiro N, Nakahara T, Kawaoka T, Hiramatsu A, Takahashi S, Ishikawa M, Kakizawa H, Awai K and Chayama K.

  Clinical outcome of sorafenib treatment in patients with advanced hepatocellular carcinoma refractory to hepatic arterial infusion chemotherapy.

  J Gastroenterol Hepatol. 2013; 28: 1834-1841.

• Onoyama M, Kitadai Y, Tanaka Y, Yuge R, Shinagawa K, Tanaka S, Yasui W and Chayama K.

  Combining molecular targeted drugs to inhibit both cancer cells and activated stromal cells in gastric cancer.

  Neoplasia. 2013; 15: 1391-1399.

• Kosaka K, Hiraga N, Imamura M, Yoshimi S, Murakami E, Nakahara T, Honda Y, Ono A, Kawaoka T, Tsuge M, Abe H, Hayes CN, Miki D, Aikata H, Ochi H, Ishida Y, Tateno C, Yoshizato K, Sasaki T and Chayama K.

  A novel TK-NOG based humanized mouse model for the study of HBV and HCV infections

  Biochem Biophys Res Commun. 2013; 441: 230-235.

• Furusho H, Miyauchi M, Hyogo H, Inubushi T, Ao M, Ouhara K, Hisatune J, Kurihara H, Sugai M, Hayes CN, Nakahara T, Aikata H, Takahashi S, Chayama K and Takata T.

  Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice.

  J Gastroenterol. 2013; 48: 1259-1270.

• Masaki K, Takaki S, Hyogo H, Kobayashi T, Fukuhara T, Naeshiro N, Honda Y, Nakahara T, Ohno A, Miyaki D, Murakami E, Nagaoki Y, Kawaoka T, Tsuge M, Hiraga N, Hiramatsu A, Imamura M, Kawakami Y, Aikata H, Ochi H, Takahashi S, Arihiro K and Chayama K.

  Utility of controlled attenuation parameter measurement for assessing liver steatosis in Japanese patients with chronic liver diseases.

  Hepatol Res. 2013; 43: 1182-1189.

• Miwata T, Hiyama T, Oka S, Tanaka S, Shimamoto F, Arihiro K and Chayama K.

  Clinicopathologic features of hyperplastic/serrated polyposis syndrome in Japan.

  J Gastroenterol Hepatol. 2013; 28: 1693-1698.

• Tsuge M, Murakami E, Imamura M, Abe H, Miki D, Hiraga N, Takahashi S, Ochi H, Nelson Hayes C, Ginba H, Matsuyama K, Kawakami H and Chayama K.

  Serum HBV RNA and HBeAg are useful markers for the safe discontinuation of nucleotide analogue treatments in chronic hepatitis B patients.

  J Gastroenterol. 2013; 48: 1188-1204.

• Ishii Y, Sasaki T, Serikawa M, Minami T, Okazaki A, Yukutake M, Ishigaki T, Kosaka K, Mouri T, Yoshimi S, Shimizu A, Tsuboi T and Chayama K.

  Elevated expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in primary sclerosing cholangitis: iotamplications for cholangiocarcinogenesis.

  Int J Oncol. 2013; 43: 1073-1079.

• Numata N, Oka S, Tanaka S, Higashiyama M, Sanomura Y, Yoshida S, Arihiro K and Chayama K.

  Clinical outcomes of endoscopic submucosal dissection for early gastric cancer in patients with chronic kidney disease.

  J Gastroenterol Hepatol. 2013; 28: 1632-1637.

• Abe Y, Aly HH, Hiraga N, Imamura M, Wakita T, Shimotohno K, Chayama K and Hijikata M.

  Thromboxane A2 synthase inhibitors prevent production of infectious hepatitis C virus in mice with humanized livers.

  Gastroenterology. 2013; 145: 658-667: e611.

• Nakano M, Oka S, Tanaka S, Aoyama T, Watari I, Hayashi R, Miyaki R, Nagai K, Sanomura Y, Yoshida S, Ueno Y and Chayama K.

  Clinical usefulness of classification by transabdominal ultrasonography for detection of small-bowel stricture.

  Scand J Gastroenterol. 2013; 48: 1041-1047.

• Ozawa S, Tanaka S, Hayashi N, Nishiyama S, Terasaki M, Nakadoi K, Kanao H, Oka S, Yoshida S and Chayama K.

  Risk factors for vertical incomplete resection in endoscopic submucosal dissection as total excisional biopsy for submucosal invasive colorectal carcinoma.

  Int J Colorectal Dis. 2013; 28: 1247-1256.

• Yoneda M, Imajo K, Eguchi Y, Fujii H, Sumida Y, Hyogo H, Ono M, Suzuki Y, Kawaguchi T, Aoki N, Sata M, Kanemasa K, Kohgo Y, Saibara T, Chayama K, Itoh Y, Yoshikawa T, Anzai K, Fujimoto K, Okanoue T, Nakajima A and Japan Study Group of Nonalcoholic Fatty Liver D.

  Noninvasive scoring systems in patients with nonalcoholic fatty liver disease with normal alanine aminotransferase levels.

  J Gastroenterol. 2013; 48: 1051-1060.

• Igawa A, Oka S, Tanaka S, Nakano M, Aoyama T, Watari I, Aikata H, Arihiro K and Chayama K.

  Small bowel metastasis of hepatocellular carcinoma detected by capsule endoscopy.

  Case Rep Gastroenterol. 2013; 7: 492-497.

• Imada S, Ishiyama K, Ide K, Kobayashi T, Amano H, Tashiro H, Arihiro K, Aikata H, Chayama K and Ohdan H.

  Inferior vena cava tumor thrombus that directly infiltrated from paracaval lymph node metastases in a patient with recurrent hepatocellular carcinoma.

  World J Surg Oncol. 2013; 11: 177.

• Watari I, Oka S, Tanaka S, Aoyama T, Imagawa H, Shishido T, Yoshida S and Chayama K.

  Effectiveness of polaprezinc for low-dose aspirin-induced small-bowel mucosal injuries as evaluated by capsule endoscopy: a pilot randomized controlled study.

  BMC Gastroenterol. 2013; 13: 108.

• Shi N, Hiraga N, Imamura M, Hayes CN, Zhang Y, Kosaka K, Okazaki A, Murakami E, Tsuge M, Abe H, Aikata H, Takahashi S, Ochi H, Tateno-Mukaidani C, Yoshizato K, Matsui H, Kanai A, Inaba T, McPhee F, Gao M and Chayama K.

  Combination therapies with NS5A, NS3 and NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice.

  Gut. 2013; 62: 1055-1061.

• Kitamoto T, Kitamoto A, Yoneda M, Hyogo H, Ochi H, Nakamura T, Teranishi H, Mizusawa S, Ueno T, Chayama K, Nakajima A, Nakao K, Sekine A and Hotta K.

  Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan.

  Hum Genet. 2013; 132: 783-792.

• Kimura T, Takahashi S, Kenjo M, Nishibuchi I, Takahashi I, Takeuchi Y, Doi Y, Kaneyasu Y, Murakami Y, Honda Y, Aikata H, Chayama K and Nagata Y.

  Dynamic computed tomography appearance of tumor response after stereotactic body radiation therapy for hepatocellular carcinoma: How should we evaluate treatment effects?

  Hepatol Res. 2013; 43: 717-727.

• Higashimaya M, Oka S, Tanaka S, Sanomura Y, Yoshida S, Hiyama T, Arihiro K, Shimamoto F and Chayama K.

  Outcome of endoscopic submucosal dissection for gastric neoplasm in relationship to endoscopic classification of submucosal fibrosis.

  Gastric Cancer. 2013; 16: 404-410.

• Nagaoki Y, Aikata H, Kobayashi T, Fukuhara T, Masaki K, Tanaka M, Naeshiro N, Nakahara T, Honda Y, Miyaki D, Kawaoka T, Takaki S, Tsuge M, Hiramatsu A, Imamura M, Hyogo H, Kawakami Y, Takahashi S, Ochi H and Chayama K.

  Risk factors for the exacerbation of esophageal varices or portosystemic encephalopathy after sustained virological response with IFN therapy for HCV-related compensated cirrhosis.

  J Gastroenterol. 2013; 48: 847-855.

• Tsuge M and Chayama K.

  Availability of monitoring serum HBV DNA plus RNA during nucleot (s)ide analogue therapy.

  J Gastroenterol. 2013; 48: 779-780.

• Kuwabara T, Hiyama T, Oka S, Urabe Y, Tanaka S, Yoshihara M, Arihiro K, Shimamoto F and Chayama K.

  Response.

  Gastrointest Endosc. 2013; 77: 973-974.

• Kitamoto A, Kitamoto T, Mizusawa S, Teranishi H, So R, Matsuo T, Nakata Y, Hyogo H, Ochi H, Nakamura T, Kamohara S, Miyatake N, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Masuzaki H, Ueno T, Chayama K, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Sakata T, Tanaka K, Matsuzawa Y, Nakao K, Sekine A and Hotta K.

  NUDT3 rs206936 is associated with body mass index in obese Japanese women.

  Endocr J. 2013; 60: 991-1000.

• Miyaki R, Yoshida S, Tanaka S, Kominami Y, Sanomura Y, Matsuo T, Oka S, Raytchev B, Tamaki T, Koide T, Kaneda K, Yoshihara M and Chayama K.

  Quantitative identification of mucosal gastric cancer under magnifying endoscopy with flexible spectral imaging color enhancement.

  J Gastroenterol Hepatol. 2013; 28: 841-847.

• Urabe Y, Ochi H, Kato N, Kumar V, Takahashi A, Muroyama R, Hosono N, Otsuka M, Tateishi R, Lo PH, Tanikawa C, Omata M, Koike K, Miki D, Abe H, Kamatani N, Toyota J, Kumada H, Kubo M, Chayama K, Nakamura Y and Matsuda K.

  A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region.

  J Hepatol. 2013; 58: 875-882.

• Arataki K, Hayes CN, Akamatsu S, Akiyama R, Abe H, Tsuge M, Miki D, Ochi H, Hiraga N, Imamura M, Takahashi S, Aikata H, Kawaoka T, Kawakami H, Ohishi W and Chayama K.

  Circulating microRNA-22 correlates with microRNA-122 and represents viral replication and liver injury in patients with chronic hepatitis B.

  J Med Virol. 2013; 85: 789-798.

• Oka S, Tanaka S, Nakadoi K, Kanao H and Chayama K.

  Risk analysis of submucosal invasive rectal carcinomas for lymph node metastasis to expand indication criteria for endoscopic resection.

  Dig Endosc. 2013; 25: S21-25.

• Aoyama T, Oka S, Aikata H, Nakano M, Watari I, Naeshiro N, Yoshida S, Tanaka S and Chayama K.

  Small bowel abnormalities in patients with compensated liver cirrhosis.

  Dig Dis Sci. 2013; 58: 1390-1396.

• Hotta K, Kitamoto A, Kitamoto T, Mizusawa S, Teranishi H, So R, Matsuo T, Nakata Y, Hyogo H, Ochi H, Nakamura T, Kamohara S, Miyatake N, Kotani K, Itoh N, Mineo I, Wada J, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Masuzaki H, Ueno T, Chayama K, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Sakata T, Tanaka K, Matsuzawa Y, Nakao K and Sekine A.

  Replication study of 15 recently published Loci for body fat distribution in the Japanese population.

  J Atheroscler Thromb. 2013; 20: 336-350.

• Hamai Y, Hihara J, Aoki Y, Taomoto J, Kishimoto I, Kobayashi Y, Miyata Y, Aikata H, Chayama K and Okada M.

  Airway stenting for tracheal obstruction due to lymph node metastasis of hepatocellular carcinoma.

  Anticancer Res. 2013; 33: 1761-1764.

• Takata S, Tanaka S, Hayashi N, Terasaki M, Nakadoi K, Kanao H, Oka S, Yoshida S and Chayama K.

  Characteristic magnifying narrow-band imaging features of colorectal tumors in each growth type.

  Int J Colorectal Dis. 2013; 28: 459-468.

• Chayama K, Hayes CN, Ohishi W and Kawakami Y.

  Response to "treatment guidelines for HCV genotype 1: mono for low, triple for high, and dual for 'middle'?".

  J Gastroenterol. 2013; 48: 557-558.

• Toyota J, Ozeki I, Karino Y, Asahina Y, Izumi N, Takahashi S, Kawakami Y, Chayama K, Kamiya N, Aoki K, Yamada I, Suzuki Y, Suzuki F and Kumada H.

  Virological response and safety of 24-week telaprevir alone in Japanese patients infected with hepatitis C virus subtype 1b.

  J Viral Hepat. 2013; 20: 167-173.

• Honda Y, Kimura T, Aikata H, Kobayashi T, Fukuhara T, Masaki K, Nakahara T, Naeshiro N, Ono A, Miyaki D, Nagaoki Y, Kawaoka T, Takaki S, Hiramatsu A, Ishikawa M, Kakizawa H, Kenjo M, Takahashi S, Awai K, Nagata Y and Chayama K.

  Stereotactic body radiation therapy combined with transcatheter arterial chemoembolization for small hepatocellular carcinoma.

  J Gastroenterol Hepatol. 2013; 28: 530-536.

• Zhang Y, Takahashi S, Tasaka A, Yoshima T, Ochi H and Chayama K.

  Involvement of microRNA-224 in cell proliferation, migration, invasion, and anti-apoptosis in hepatocellular carcinoma.

  J Gastroenterol Hepatol. 2013; 28: 565-575.

• Tashiro H, Ide K, Amano H, Kobayashi T, Onoe T, Ishiyama K, Kuroda S, Tazawa H, Kono H, Aikata H, Takahashi S, Chayama K and Ohdan H.

  Surgical treatment for portosystemic encephalopathy in patients with liver cirrhosis: Occlusion of portosystemic shunt in combination with splenectomy.

  Hepatol Res. 2013; 43: 249-254.

• Tanaka S, Terasaki M, Hayashi N, Oka S and Chayama K.

  Warning for unprincipled colorectal endoscopic submucosal dissection: accurate diagnosis and reasonable treatment strategy.

  Dig Endosc. 2013; 25: 107-116.

• Takamura A, Ito M, Boda T, Matsumoto Y, Tanaka S, Yoshihara M and Chayama K.

  High expression of gastrin receptor protein in injured mucosa of Helicobacter pylori-positive gastritis.

  Dig Dis Sci. 2013; 58: 634-640.

• Izumi N, Asahina Y, Kurosaki M, Yamada G, Kawai T, Kajiwara E, Okamura Y, Takeuchi T, Yokosuka O, Kariyama K, Toyoda J, Inao M, Tanaka E, Moriwaki H, Adachi H, Katsushima S, Kudo M, Takaguchi K, Hiasa Y, Chayama K, Yatsuhashi H, Oketani M and Kumada H.

  Inhibition of hepatocellular carcinoma by PegIFNalpha-2a in patients with chronic hepatitis C: a nationwide multicenter cooperative study.

  J Gastroenterol. 2013; 48: 382-390.

• Tanaka S, Hayashi N, Oka S and Chayama K.

  Endoscopic assessment of colorectal cancer with superficial or deep submucosal invasion using magnifying colonoscopy.

  Clin Endosc. 2013; 46: 138-146.

• Higashimaya M, Oka S, Tanaka S, Numata N, Sanomura Y, Yoshida S, Arihiro K and Chayama K.

  Endoscopic submucosal dissection for residual early gastric cancer after endoscopic submucosal dissection.

  Gastrointest Endosc. 2013; 77: 298-302.

• Chayama K and Hayes CN.

  Interleukin-28B polymorphisms and hepatitis C virus clearance.

  Genome Med. 2013; 5: 6.

• Nakano R, Maekawa T, Abe H, Hayashida Y, Ochi H, Tsunoda T, Kumada H, Kamatani N, Nakamura Y and Chayama K.

  Single-nucleotide polymorphisms in GALNT8 are associated with the response to interferon therapy for chronic hepatitis C.

  J Gen Virol. 2013; 94: 81-89.

• Chayama K, Hayes CN, Ohishi W and Kawakami Y.

  Treatment of chronic hepatitis C virus infection in Japan: update on therapy and guidelines.

  J Gastroenterol. 2013; 48: 1-12.