広島大学大学院医歯薬保健学研究科

消化器⋅代謝内科学

(広島大学病院 旧第一内科)

業績・活動

主要業績

主要業績

  • Shimizu T. Tanaka S. Haruma K. Kitadai Y. Yoshihara M. Sumii K. Kajiyama G, and Shimamoto F, Growth characteristics of rectal carcinoid tumors. Oncology, 2000; 59: 229-37.

  • Kusunoki H. Haruma K. Hata J. Tani H. Okamoto E. Sumii K, and Kajiyama G, Real-time ultrasonographic assessment of antroduodenal motility after ingestion of solid and liquid meals by patients with functional dyspepsia. J Gastroenterol Hepatol, 2000; 15: 1022-7.

  • Haruma K, Trend toward a reduced prevalence of Helicobacter pylori infection, chronic gastritis, and gastric cancer in Japan. Gastroenterol Clin North Am, 2000; 29: 623-31.

  • Higashi Y1, Sasaki S, Kurisu S, Yoshimizu A, Sasaki N, Matsuura H, Kajiyama G, Oshima T. Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects: role of endothelium-derived nitric oxide. Circulation, 2000; 100: 1194-202.

  • Ochi H. Tazuma S. Kajihara T. Hyogo H. Sunami Y. Yasumiba S. Nakai K. Tsuboi K. Asamoto Y. Sakomoto M, and Kajiyama G, Factors affecting gallstone recurrence after successful extracorporeal shock wave lithotripsy. J Clin Gastroenterol, 2000; 31: 230-2.

  • Yoshida S. Hata J. Haruma K. Kusunoki H. Sumii K, and Kajiyama G, Evaluation of flash echo imaging of the canine gastrointestinal tract. J Ultrasound Med, 2000; 19: 751-5.

  • Oshima T. Nakano Y. Ozono R. Higashi Y. Sasaki S. Ueda A. Oue Y. Matsuura H, and Kambe M, Abnormal Ca2+ handling and increased Mg2+ permeability in platelets of hypertensive rats. Hypertens Res, 2000; 23: 651-7.

  • Aikata H. Takaishi H. Kawakami Y. Takahashi S. Kitamoto M. Nakanishi T. Nakamura Y. Shimamoto F. Kajiyama G, and Ide T, Telomere reduction in human liver tissues with age and chronic inflammation. Exp Cell Res, 2000; 256: 578-82.

  • Aisaka Y. Watanabe Y. Kamiyasu M. Masanaga T. Tsuji K. Nakanishi T. Kajiyama G, and Gershwin M E, Immune-mediated cholangiohepatitis in neonatally thymectomized mice: the role of T cells and analysis of T-cell receptor Vbeta usage. J Autoimmun, 2000; 14: 239-46.

  • Nagata S. Tanaka S. Haruma K. Yoshihara M. Sumii K. Kajiyama G, and Shimamoto F, Pit pattern diagnosis of early colorectal carcinoma by magnifying colonoscopy: clinical and histological implications. Int J Oncol, 2000; 16: 927-34.

  • Hirota Y. Tanaka S. Haruma K. Yoshihara M. Sumii K. Kajiyama G. Shimamoto F, and Kohno N, pS2 expression as a possible diagnostic marker of colorectal carcinoma in ulcerative colitis. Oncol Rep, 2000; 7: 233-9.

  • Takahashi S. Kitamoto M. Takaishi H. Aikata H. Kawakami Y. Nakanishi T. Shimamoto F. Tahara E. Tahara H. Ide T, and Kajiyama G, Expression of telomerase component genes in hepatocellular carcinomas. Eur J Cancer, 2000; 36: 496-502.

  • Haruma K. Komoto K. Kamada T. Ito M. Kitadai Y. Yoshihara M. Sumii K, and Kajiyama G, Helicobacter pylori infection is a major risk factor for gastric carcinoma in young patients. Scand J Gastroenterol, 2000; 35: 255-9.

  • Haruma K. Kamada T. Kawaguchi H. Okamoto S. Yoshihara M. Sumii K. Inoue M. Kishimoto S. Kajiyama G, and Miyoshi A, Effect of age and Helicobacter pylori infection on gastric acid secretion. J Gastroenterol Hepatol, 2000; 15: 277-83.

  • Haruma K. Hamada H. Mihara M. Kamada T. Yoshihara M. Sumii K. Kajiyama G, and Kawanishi M, Negative association between Helicobacter pylori infection and reflux esophagitis in older patients: case-control study in Japan. Helicobacter, 2000; 5: 24-9.

  • Ozono R. Matsumoto T. Shingu T. Oshima T. Teranishi Y. Kambe M. Matsuura H. Kajiyama G. Wang Z Q. Moore A F, and Carey R M, Expression and localization of angiotensin subtype receptor proteins in the hypertensive rat heart. Am J Physiol Regul Integr Comp Physiol, 2000; 278: R781-9.

  • Kariya K. Koyama S. Nakashima S. Oshiro T. Morinaka K, and Kikuchi A, Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylation. J Biol Chem, 2000; 275: 18399-406.

  • Nojima K. Sumii K. Sumii M. Okahara S. Haruma K. Yoshihara M, and Kajiyama G, Acid-sensitive and alkaline-sensitive sensory neurons regulate pH dependent gastrin secretion in rat. Dig Dis Sci, 2000; 45: 1217-26.

  • Chen X. Haruma K. Kamada T. Mihara M. Komoto K. Yoshihara M. Sumii K, and Kajiyama G, Factors that affect results of the 13C urea breath test in Japanese patients. Helicobacter, 2000; 5: 98-103.

  • Hamada H. Haruma K. Mihara M. Kamada T. Yoshihara M. Sumii K. Kajiyama G, and Kawanishi M, High incidence of reflux oesophagitis after eradication therapy for Helicobacter pylori: impacts of hiatal hernia and corpus gastritis. Aliment Pharmacol Ther, 2000; 14: 729-35.

  • Matsumoto T. Ozono R. Sasaki N. Oshima T. Matsuura H. Kajiyama G. Carey R M, and Kambe M, Type 1A dopamine receptor expression in the heart is not altered in spontaneously hypertensive rats. Am J Hypertens, 2000; 13: 673-7.

  • Tanaka S. Haruma K. Oh E H. Nagata S. Hirota Y. Furudoi A. Amioka T. Kitadai Y. Yoshihara M, and Shimamoto F, Conditions of curability after endoscopic resection for colorectal carcinoma with submucosally massive invasion. Oncol Rep, 2000; 7: 783-8.

  • Goishi H. Tanaka S. Haruma K. Yoshihara M. Sumii K. Kajiyama G, and Shimamoto F, Predictive value of cathepsin D and Ki-67 expression at the deepest penetration site for lymph node metastases in gastric cancer. Oncol Rep, 2000; 7: 713-8.

  • Kido S. Haruma K. Kitadai Y. Yoshihara M. Sumii K. Kajiyama G, and Watanabe H, Enhanced tumorigenicity of insulinoma by X-irradiation of the gastric regions in Sprague-Dawley male rats. J Gastroenterol Hepatol, 2000; 15: 766-70.

  • Kitadai Y. Haruma K. Mukaida N. Ohmoto Y. Matsutani N. Yasui W. Yamamoto S. Sumii K. Kajiyama G. Fidler I J, and Tahara E, Regulation of disease-progression genes in human gastric carcinoma cells by interleukin 8. Clin Cancer Res, 2000; 6: 2735-40.

  • Hattori Y. Tazuma S. Yamashita G. Ochi H. Sunami Y. Nishioka T. Hyogo H. Yasumiba S. Kajihara T. Nakai K. Tsuboi K. Asamoto Y. Sakomoto M, and Kajiyama G, Role of phospholipase A2 in cholesterol gallstone formation is associated with biliary phospholipid species selection at the site of hepatic excretion: indirect evidence. Dig Dis Sci, 2000; 45: 1413-21.

  • Takaishi H. Kitamoto M. Takahashi S. Aikata H. Kawakami Y. Nakanishi T. Nakamura Y. Shimamoto F. Kajiyama G, and Ide T, Precancerous hepatic nodules had significant levels of telomerase activity determined by sensitive quantitation using a hybridization protection assay. Cancer, 2000; 88: 312-7.

  • Kimura T. Tanaka S. Haruma K. Sumii K. Kajiyama G. Shimamoto F, and Kohno N, Clinical significance of MUC1 and E-cadherin expression, cellular proliferation, and angiogenesis at the deepest invasive portion of colorectal cancer. Int J Oncol, 2000; 16: 55-64.

  • Yamamoto S. Kitadai Y. Tsuchida A. Sasaki T. Matsubara K, and Kajiyama G, Expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human gallbladder lesions. Eur J Cancer, 2000; 36: 257-63.

  • Hananoki M. Haruma K. Tsuga K. Hata J. Sumii K, and Kajiyama G, Evaluation of lower oesophageal sphincter pressure using endoscopic manometric sleeve assembly. J Gastroenterol Hepatol, 2000; 15: 121-6.

  • Haruma K. Ito M. Kohmoto K. Kamada T. Kitada Y. Yasui W. Tahara E, and Kajiyama G, Expression of cell cycle regulators and growth factor/receptor systems in gastric carcinoma in young adults: association with Helicobacter pylori infection. Int J Mol Med, 2000; 5: 185-90.

  • Sasaki S. Oshima T. Matsuura H. Ozono R. Higashi Y. Sasaki N. Matsumoto T. Nakano Y. Ueda A. Yoshimizu A. Kurisu S. Kambe M, and Kajiyama G, Abnormal magnesium status in patients with cardiovascular diseases. Clin Sci (Lond) , 2000; 98: 175-81.

  • Higashi Y. Sasaki S. Nakagawa K. Ueda T. Yoshimizu A. Kurisu S. Matsuura H. Kajiyama G, and Oshima T, A comparison of angiotensin-converting enzyme inhibitors, calcium antagonists, beta-blockers and diuretic agents on reactive hyperemia in patients with essential hypertension: a multicenter study. J Am Coll Cardiol, 2000; 35: 284-91.

  • Tani H. Singer W. McPhee B R. Opfer-Gehrking T L. Haruma K. Kajiyama G, and Low P A, Splanchnic-mesenteric capacitance bed in the postural tachycardia syndrome (POTS). Auton Neurosci, 2000; 86: 107-13.

  • Teragawa H. Kato M. Yamagata T. Matsuura H, and Kajiyama G, The preventive effect of magnesium on coronary spasm in patients with vasospastic angina. Chest, 2000; 118: 1690-5.

  • Kawakami Y. Kitamoto M. Nakanishi T. Yasui W. Tahara E. Nakayama J. Ishikawa F. Tahara H. Ide T, and Kajiyama G, Immuno-histochemical detection of human telomerase reverse transcriptase in human liver tissues. Oncogene, 2000; 19: 3888-93.

  • Hyogo H. Tazuma S, and Kajiyama G, Biliary excretory function is regulated by canalicular membrane fluidity associated with phospholipid fatty acyl chains in the bilayer: implications for the pathophysiology of cholestasis. J Gastroenterol Hepatol, 2000; 15: 887-94.

  • Kunihiro M. Tanaka S. Haruma K. Kitadai Y. Yoshihara M. Sumii K. Kajiyama G, and Nishiyama M, Electrocautery snare resection stimulates cellular proliferation of residual colorectal tumor: an increasing gene expression related to tumor growth. Dis Colon Rectum, 2000; 43: 1107-15.

  • Kamada T. Haruma K. Miyoshi E. Mihara M. Kitadai Y. Yoshihara M. Sumii K. Kajiyama G. Tahara K. Mukai T. Kawamura Y, and Hattori N, Cetraxate, a mucosal protective agent, combined with omeprazole, amoxycillin, and clarithromycin increases the eradication rate of helicobacter pylori in smokers. Aliment Pharmacol Ther, 2000; 14: 1089-94.

  • Locke C R, 3rd. Talley N J. Nelson D K. Haruma K. Weaver A L. Zinsmeister A R, and Melton L J, 3rd, Helicobacter pylori and dyspepsia: a population-based study of the organism and host. Am J Gastroenterol, 2000; 95: 1906-13.

  • Kishimoto S. Haruma K. Tari A. Sakurai K. Nakano M, and Nakagawa Y, Rebamipide, an antiulcer drug, prevents DSS-induced colitis formation in rats. Dig Dis Sci, 2000; 45: 1608-16.

  • Matsumoto T. Ozono R. Oshima T. Matsuura H. Sueda T. Kajiyama G, and Kambe M, Type 2 angiotensin II receptor is downregulated in cardiomyocytes of patients with heart failure. Cardiovasc Res, 2000; 46: 73-81.

  • Ikeda K. Saitoh S. Kobayashi M. Suzuki Y. Tsubota A. Suzuki F. Arase Y. Murashima N. Chayama K, and Kumada H, Distinction between chronic hepatitis and liver cirrhosis in patients with hepatitis C virus infection. Practical discriminant function using common laboratory data. Hepatol Res, 2000; 18: 252-266.

  • Chayama K. Suzuki F. Tsubota A. Kobayashi M. Arase Y. Saitoh S. Suzuki Y. Murashima N. Ikeda K. Takahashi N. Kinoshita M, and Kumada H, Association of amino acid sequence in the PKR-eIF2 phosphorylation homology domain and response to interferon therapy. Hepatology, 2000; 32: 1138-44.

  • Ikeda K. Arase Y. Saitoh S. Kobayashi M. Suzuki Y. Suzuki F. Tsubota A. Chayama K. Murashima N, and Kumada H, Interferon beta prevents recurrence of hepatocellular carcinoma after complete resection or ablation of the primary tumor-A prospective randomized study of hepatitis C virus-related liver cancer. Hepatology, 2000; 32: 228-32.

  • Kobayashi M. Ikeda K. Saitoh S. Suzuki F. Tsubota A. Suzuki Y. Arase Y. Murashima N. Chayama K, and Kumada H, Incidence of primary cholangiocellular carcinoma of the liver in japanese patients with hepatitis C virus-related cirrhosis. Cancer, 2000; 88: 2471-7.

  • Ubara Y. Hara S. Katori H. Tagami T. Kitamura A. Yokota M. Matsushita Y. Takemoto F. Yamada A. Nagahama K. Hara M, and Chayama K, Splenectomy may improve the glomerulopathy of type II mixed cryoglobulinemia. Am J Kidney Dis, 2000; 35: 1186-92.

  • Arase Y. Ikeda K. Chayama K. Murashima N. Tsubota A. Suzuki Y. Saitoh S. Kobayashi M. Suzuki F, and Kumada H, Fluctuation patterns of HCV-RNA serum level in patients with chronic hepatitis C. J Gastroenterol, 2000; 35: 221-5.

  • Kobyashi M. Chayama K. Arase Y. Tsubota A. Saitoh S. Suzuki Y. Kobayashi M. Murashima N. Ikeda K. Hagiwara M. Hashimoto R. Nakagawa M. Matsuda M, and Kumada H, Progressive and sufficient decrease of hepatitis B core antibody can predict the disappearance of hepatitis B virus DNA in Japanese patients with hepatitis B surface antigen clearance. J Gastroenterol, 2000; 35: 753-7.

  • Kobayashi M. Ikeda K. Akuta N. Someya T. Suzuki F. Tsubota A. Suzuki Y. Saitoh S. Arase Y. Chayama K, and Kumada H, Relationship between five-year histological outcome and serial changes in serum alanine aminotransferase in patients with biochemical and virological relapse after interferon treatment for chronic hepatitis C. Intervirology, 2000; 43: 174-9.

  • Arase Y. Ikeda K. Chayama K. Murashima N. Tsubota A. Suzuki Y. Saitoh S. Kobayashi M. Suzuki F, and Kumada H, Increased response rate to interferon therapy after a second course in hepatitis C patients who show relapse after the initial course. J Gastroenterol, 2000; 35: 607-12.

  • Kariwa H. Yoshimatsu K. Araki K. Chayama K. Kumada H. Ogino M. Ebihara H. Murphy M E. Mizutani T. Takashima I, and Arikawa J, Detection of hantaviral antibodies among patients with hepatitis of unknown etiology in Japan. Microbiol Immunol, 2000; 44: 357-62.

  • Ikeda K. Saitoh S. Kobayashi M. Suzuki Y. Suzuki F. Tsubota A. Arase Y. Chayama K. Murashima N, and Kumada H, Hepatic vascular side effects of styrene maleic acid neocarzinostatin in the treatment of hepatocellular carcinoma. J Gastroenterol, 2000; 35: 353-60.

  • Tanaka S. Haruma K. Ito M. Nagata S. Oh-e H. Hirota Y. Kunihiro M. Kitadai Y. Yosihara M. Sumii K, and Kajiyama G, Detailed colonoscopy for detecting early superficial carcinoma: recent developments. J Gastroenterol, 2000; 35 Suppl 12: 121-5.

  • Sumii K, What is the role of Helicobacter pylori infection in ZES-associated peptic ulcer? J Gastroenterol, 2000; 35: 794-5.

  • Sunami Y T S, Kajiyama G., Gallbladder Dysfunction Enhances Physical Density But Not Biochemical Metastability of Biliary Vesicles. Digestive Diseases and Sciences. , 2000; 45: 2382-2391.

  • Kajihara T. Tazuma S. Yamashita G, and Kajiyama G, Bilirubin overload modulates bile canalicular membrane fluidity in rats: association with disproportionate reduction of biliary lipid secretion. J Gastroenterol, 2000; 35: 450-5.

  • Nakano Y. Oshima T. Sasaki S. Yamaoka K. Matsumoto T. Hirao H. Ozono R. Matsuura H. Kajiyama G, and Kambe M, Vitamin D receptor gene polymorphism is associated with serum total and ionized calcium concentration. J Mol Med (Berl) , 2000; 78: 575-9.

  • Ito M K S, Tanaka S, Chayama K, Yoshihara M, Haruma K., Corrrespondence. Dig Liver Dis. , 2000 982.

  • Higashi Y S S, Kurisu S, Yoshimizu A, Sasaki N, Matsuura H, Kajiyama G., Exercise and endothelial function. Circulation, 2000; 102: e179.