広島大学大学院医歯薬保健学研究科

消化器⋅代謝内科学

(広島大学病院 旧第一内科)

業績・活動

主要業績

主要業績

  • Tanaka S, Clinical significance of histologic heterogeneity in submucosal invasive differentiated type gastric carcinoma with respect to endoscopic treatment. J Gastroenterol, 2001; 36: 725-6.

  • Sanada M. Higashi Y. Nakagawa K. Sasaki S. Kodama I. Sakashita T. Tsuda M, and Ohama K, Estrogen replacement therapy in postmenopausal women augments reactive hyperemia in the forearm by reducing angiotensin converting enzyme activity. Atherosclerosis, 2001; 158: 391-7.

  • Hamada H. Haruma K. Mihara M. Kamada T. Sumii K, and Kajiyama G, Protective effect of ammonia against reflux esophagitis in rats. Dig Dis Sci, 2001; 46: 976-80.

  • Sanada M. Higashi Y. Nakagawa K. Sasaki S. Kodama I. Tsuda M. Nagai N, and Ohama K, Relationship between the angiotensin-converting enzyme genotype and the forearm vasodilator response to estrogen replacement therapy in postmenopausal women. J Am Coll Cardiol, 2001; 37: 1529-35.

  • Higashi Y. Sasaki S. Nakagawa K. Matsuura H. Kajiyama G, and Oshima T, Effect of the angiotensin-converting enzyme inhibitor imidapril on reactive hyperemia in patients with essential hypertension: relationship between treatment periods and resistance artery endothelial function. J Am Coll Cardiol, 2001; 37: 863-70.

  • Hiyama T. Haruma K. Kitadai Y. Miyamoto M. Tanaka S. Yoshihara M. Sumii K. Shimamoto F, and Kajiyama G, B-cell monoclonality in Helicobacter pylori-associated chronic atrophic gastritis. Virchows Arch, 2001; 438: 232-7.

  • Tari A. Kuruhara Y. Yonei Y. Yamauchi R. Okahara S. Sumii K, and Kajiyama G, Effects of omeprazole and pirenzepine on enterochromaffin-like cells and parietal cells in rat stomach. J Gastroenterol, 2001; 36: 375-85.

  • Yasumiba S. Tazuma S. Ochi H. Kajiyama G, and Mdt, Modifying hepatic phospholipid synthesis associates with biliary phospholipid secretion rate in a transporter-independent manner in rats: relation to canalicular membrane fluidity. Dig Dis Sci, 2001; 46: 1290-8.

  • Sugino H. Ozono R. Kurisu S. Matsuura H. Ishida M. Oshima T. Kambe M. Teranishi Y. Masaki H, and Matsubara H, Apoptosis is not increased in myocardium overexpressing type 2 angiotensin II receptor in transgenic mice. Hypertension, 2001; 37: 1394-8.

  • Kamada K. Nakanishi T. Kitamoto M. Aikata H. Kawakami Y. Ito K. Asahara T, and Kajiyama G, Long-term prognosis of patients undergoing transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma: comparison of cisplatin lipiodol suspension and doxorubicin hydrochloride emulsion. J Vasc Interv Radiol, 2001; 12: 847-54.

  • Sasaki S. Higashi Y. Nakagawa K. Matsuura H. Kajiyama G, and Oshima T, Effects of angiotensin-(1-7) on forearm circulation in normotensive subjects and patients with essential hypertension. Hypertension, 2001; 38: 90-4.

  • Higashi Y. Sasaki S. Nakagawa K. Matsuura H. Kajiyama G, and Oshima T, A noninvasive measurement of reactive hyperemia that can be used to assess resistance artery endothelial function in humans. Am J Cardiol, 2001; 87: 121-5, a9.

  • Inoue H. Tsuchida A. Kawasaki Y. Fujimoto Y. Yamasaki S, and Kajiyama G, Preoperative diagnosis of intraductal papillary-mucinous tumors of the pancreas with attention to telomerase activity. Cancer, 2001; 91: 35-41.

  • Oh-e H. Tanaka S. Kitadai Y. Shimamoto F. Yoshihara M, and Haruma K, Cathepsin D expression as a possible predictor of lymph node metastasis in submucosal colorectal cancer. Eur J Cancer, 2001; 37: 180-8.

  • Nakamura M. Haruma K. Kamada T. Mihara M. Yoshihara M. Imagawa M, and Kajiyama G, Duodenogastric reflux is associated with antral metaplastic gastritis. Gastrointest Endosc, 2001; 53: 53-9.

  • Teranishi Y. Iida N. Ishioka N. Sugino H, and Amano T, Is compensatory vasoconstrictor tone in the hindquarter vascular region induced by hemorrhage in conscious spontaneously hypertensive rats? Jpn J Pharmacol, 2001; 85: 109-13.

  • Oh-e H. Tanaka S. Kitadai Y. Shimamoto F. Yoshihara M, and Haruma K, Angiogenesis at the site of deepest penetration predicts lymph node metastasis of submucosal colorectal cancer. Dis Colon Rectum, 2001; 44: 1129-36.

  • Nogi K. Haruma K. Taniguchi H. Yomota E. Okajima M. Hananoki M. Hata J. Kusunoki H, and Onoda Y, Duodenogastric reflux following cholecystectomy in the dog: role of antroduodenal motor function. Aliment Pharmacol Ther, 2001; 15: 1233-8.

  • Kawai Y. Tazuma S, and Inoue M, Bile acid reflux and possible inhibition of Helicobacter pylori infection in subjects without gastric surgery. Dig Dis Sci, 2001; 46: 1779-83.

  • Teragawa H. Kato M. Yamagata T. Matsuura H, and Kajiyama G, Magnesium causes nitric oxide independent coronary artery vasodilation in humans. Heart, 2001; 86: 212-6.

  • Matsumoto A. Kitamoto M. Imamura M. Nakanishi T. Ono C. Ito K, and Kajiyama G, Three-dimensional portography using multislice helical CT is clinically useful for management of gastric fundic varices. AJR Am J Roentgenol, 2001; 176: 899-905.

  • Sanada M. Higashi Y. Nakagawa K. Sasaki S. Kodama I. Sakashita T. Tsuda M, and Ohama K, Oral estrogen replacement therapy increases forearm reactive hyperemia accompanied by increases in serum levels of nitric oxide in postmenopausal women. Gynecol Endocrinol, 2001; 15: 150-7.

  • Yasunobu Y. Hayashi K. Shingu T. Yamagata T. Kajiyama G, and Kambe M, Coronary atherosclerosis and oxidative stress as reflected by autoantibodies against oxidized low-density lipoprotein and oxysterols. Atherosclerosis, 2001; 155: 445-53.

  • Tazuma S and Kajiyama G, Carcinogenesis of malignant lesions of the gall bladder. The impact of chronic inflammation and gallstones. Langenbecks Arch Surg, 2001; 386: 224-9.

  • Nakai K. Tazuma S. Ochi H, and Chayama K, Does bilirubin play a role in the pathogenesis of both cholesterol and pigment gallstone formation? Direct and indirect influences of bilirubin on bile lithogenicity. Biochim Biophys Acta, 2001; 1534: 78-84.

  • Tazuma S and Chayama K, Hepatic hydroxylation of bile acids and chronic liver diseases: do transporters play a mechanistic role? J Gastroenterol Hepatol, 2001; 16: 1313-5.

  • Teragawa H. Kato M. Kurokawa J. Yamagata T. Matsuura H, and Chayama K, Endothelial dysfunction is an independent factor responsible for vasospastic angina. Clin Sci (Lond) , 2001; 101: 707-13.

  • Miyoshi E. Haruma K. Hiyama T. Tanaka S. Yoshihara M. Shimamoto F, and Chayama K, Microsatellite instability is a genetic marker for the development of multiple gastric cancers. Int J Cancer, 2001; 95: 350-3.

  • Teragawa H. Kato M. Kurokawa J. Yamagata T. Matsuura H, and Chayama K, Usefulness of flow-mediated dilation of the brachial artery and/or the intima-media thickness of the carotid artery in predicting coronary narrowing in patients suspected of having coronary artery disease. Am J Cardiol, 2001; 88: 1147-51.

  • Asamoto Y. Tazuma S. Ochi H. Chayama K, and Suzuki H, Bile-salt hydrophobicity is a key factor regulating rat liver plasma-membrane communication: relation to bilayer structure, fluidity and transporter expression and function. Biochem J, 2001; 359: 605-10.

  • Higashi Y. Sasaki S. Nakagawa K. Kimura M. Noma K. Hara K. Matsuura H. Chayama K, and Oshima T, Sodium chloride loading does not alter endothelium-dependent vasodilation of forearm vasculature in either salt-sensitive or salt-resistant patients with essential hypertension. Hypertension Research, 2001; 24: 711-6.

  • Futagami K. Hata J. Haruma K. Yamashita N. Yoshida S. Tanaka S, and Chayama K, Extracorporeal ultrasound is an effective diagnostic alternative to endoscopic ultrasound for gastric submucosal tumours. Scand J Gastroenterol, 2001; 36: 1222-6.

  • Nakano Y. Oshima T. Sasaki S. Higashi Y. Ozono R. Takenaka S. Miura F. Hirao H. Matsuura H. Chayama K, and Kambe M, Calorie restriction reduced blood pressure in obesity hypertensives by improvement of autonomic nerve activity and insulin sensitivity. J Cardiovasc Pharmacol, 2001; 38 Suppl 1: S69-74.

  • Higashi Y. Sasaki S. Nakagawa K. Matsuura H. Chayama K, and Oshima T, Effect of obesity on endothelium-dependent, nitric oxide-mediated vasodilation in normotensive individuals and patients with essential hypertension. Am J Hypertens, 2001; 14: 1038-45.

  • Nagata S. Tanaka S. Haruma K. Kitadai Y. Yoshihara M. Shimamoto F. Kohno N, and Chayama K, MUC1 and cathepsin D expression in early colorectal carcinoma showing V type pit pattern. Int J Oncol, 2001; 19: 665-72.

  • Kitadai Y. Amioka T. Haruma K. Tanaka S. Yoshihara M. Sumii K. Matsutani N. Yasui W, and Chayama K, Clinicopathological significance of vascular endothelial growth factor (VEGF)-C in human esophageal squamous cell carcinomas. Int J Cancer, 2001; 93: 662-6.

  • Chen X. Haruma K. Kamada T. Hartori N. Yoshihara M. Kitadai Y. Tanaka S. Sumii K, and Chayama K, A low 13C-urea breath test value is associated with increased risk of gastric cancer. J Gastroenterol, 2001; 36: 601-5.

  • Matsutani N. Yokozaki H. Tahara E. Tahara H. Kuniyasu H. Haruma K. Chayama K, and Yasui W, Expression of telomeric repeat binding factor 1 and 2 and TRF1-interacting nuclear protein 2 in human gastric carcinomas. Int J Oncol, 2001; 19: 507-12.

  • Arase Y. Chayama K. Ikeda K. Tsubota A. Suzuki Y. Saitoh S. Kobayashi M. Suzuki F. Akuta N. Someya T, and Kumada H, Randomized controlled clinical trial of lymphoblastoid interferon-alpha for chronic hepatitis C. Hepatol Res, 2001; 21: 55-66.

  • Kimura S. Mieno H. Tamaki K. Inoue M, and Chayama K, Nonselective cation channel as a Ca(2+) influx pathway in pepsinogen-secreting cells of bullfrog esophagus. Am J Physiol Gastrointest Liver Physiol, 2001; 281: G333-41.

  • Kido S. Kitadai Y. Hattori N. Haruma K. Kido T. Ohta M. Tanaka S. Yoshihara M. Sumii K. Ohmoto Y, and Chayama K, Interleukin 8 and vascular endothelial growth factor -- prognostic factors in human gastric carcinomas? Eur J Cancer, 2001; 37: 1482-7.

  • Hiyama T. Haruma K. Kitadai Y. Masuda H. Miyamoto M. Ito M. Kamada T. Tanaka S. Uemura N. Yoshihara M. Sumii K. Shimamoto F, and Chayama K, Clinicopathological features of gastric mucosa-associated lymphoid tissue lymphoma: a comparison with diffuse large B-cell lymphoma without a mucosa-associated lymphoid tissue lymphoma component. J Gastroenterol Hepatol, 2001; 16: 734-9.

  • Tanaka S. Haruma K. Oka S. Takahashi R. Kunihiro M. Kitadai Y. Yoshihara M. Shimamoto F, and Chayama K, Clinicopathologic features and endoscopic treatment of superficially spreading colorectal neoplasms larger than 20 mm. Gastrointest Endosc, 2001; 54: 62-6.

  • Murachima N. Ikeda K. Kobayashi M. Saitoh S. Chayama K. Tsubota A. Suzuki Y. Suzuki F. Arase Y, and Kumada H, Incidence of the appearance of the red color sign on esophageal varices and its predictive factors: long-term observations of 359 patients with cirrhosis. J Gastroenterol, 2001; 36: 368-74.

  • Tazuma S. Horikawa K. Ochi H. Nishioka T. Sunami Y. Yasumiba S. Asamoto Y. Tsuboi K. Nakai K. Sakomoto M. Kanno K. Yamaguchi A. Numata Y, and Chayama K, Dose-dependent conjugation of sulfobromophthalein and hepatic transit time in bile fistula rats: role of the microtubule-dependent vesicle pathway. Dig Dis Sci, 2001; 46: 1285-9.

  • Chayama K. Suzuki F. Tsubota A. Akuta N. Someya T. Kobayashi M. Arase Y. Saitoh S. Suzuki Y. Ikeda K, and Kumada H, Evaluation of quantitative measurements of hepatitis C virus RNA to predict sustained response to interferon by genotype. J Virol Methods, 2001; 95: 33-45.

  • Akuta N. Chayama K. Suzuki F. Someya T. Kobayashi M. Tsubota A. Suzuki Y. Saitoh S. Arase Y. Ikeda K, and Kumada H, Risk factors of hepatitis C virus-related liver cirrhosis in young adults: positive family history of liver disease and transporter associated with antigen processing 2(TAP2)*0201 Allele. J Med Virol, 2001; 64: 109-16.

  • Hiyama T. Haruma K. Kitadai Y. Ito M. Masuda H. Miyamoto M. Tanaka S. Yoshihara M. Sumii K. Shimamoto F, and Chayama K, Helicobacter pylori eradication therapy for high-grade mucosa-associated lymphoid tissue lymphomas of the stomach with analysis of p53 and K-ras alteration and microsatellite instability. Int J Oncol, 2001; 18: 1207-12.

  • Sunami Y. Tazuma S, and Chayama K, Is a role of phospholipase A(2) in cholesterol gallstone formation phospholipid species-dependent? Biochim Biophys Acta, 2001; 1532: 51-9.

  • Nakano Y. Oshima T. Ozono R. Higashi Y. Sasaki S. Matsumoto T. Matsuura H. Chayama K, and Kambe M, Non-dipper phenomenon in essential hypertension is related to blunted nocturnal rise and fall of sympatho-vagal nervous activity and progress in retinopathy. Auton Neurosci, 2001; 88: 181-6.

  • Ito M. Haruma K. Kamada T. Kitadai Y. Hidaka T. Tsuda T. Komatsu H. Fukuhara T. Yoshihara M, and Chayama K, Reduction in the incidence of Helicobacter pylori-associated carcinoma in Japanese young adults. Oncol Rep, 2001; 8: 633-6.

  • Fujimoto Y. Sasaki T. Tsuchida A, and Chayama K, Angiotensin II type 1 receptor expression in human pancreatic cancer and growth inhibition by angiotensin II type 1 receptor antagonist. FEBS Lett, 2001; 495: 197-200.

  • Suzuki F. Chayama K. Tsubota A. Akuta N. Someya T. Kobayashi M. Suzuki Y. Saitoh S. Arase Y. Ikeda K, and Kumada H, Twice-daily administration of interferon-beta for chronic hepatitis C is not superior to a once-daily regimen. J Gastroenterol, 2001; 36: 242-7.

  • Ikeda K. Saitoh S. Kobayashi M. Suzuki Y. Suzuki F. Tsubota A. Arase Y. Murashima N. Chayama K, and Kumada H, Long-term interferon therapy for 1 year or longer reduces the hepatocellular carcinogenesis rate in patients with liver cirrhosis caused by hepatitis C virus: a pilot study. J Gastroenterol Hepatol, 2001; 16: 406-15.

  • Yasumiba S. Tazuma S. Ochi H. Chayama K, and Kajiyama G, Cyclosporin A reduces canalicular membrane fluidity and regulates transporter function in rats. Biochem J, 2001; 354: 591-6.

  • Hiyama T. Haruma K. Kitadai Y. Ito M. Masuda H. Miyamoto M. Tanaka S. Yoshihara M. Sumii K. Shimamoto F, and Chayama K, Microsatellite instability at D18S61 is associated with no regression of gastric mucosa-associated lymphoid tissue lymphoma after Helicobacter pylori eradication. Oncol Rep, 2001; 8: 293-7.

  • Hiyama T. Haruma K. Kitadai Y. Ito M. Masuda H. Miyamoto M. Tanaka S. Yoshihara M. Sumii K. Shimamoto F, and Chayama K, c-myc gene mutation in gastric mucosa-associated lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma. Oncol Rep, 2001; 8: 289-92.

  • Tsubota A. Arase Y. Saitoh S. Kobayashi M. Suzuki Y. Suzuki F. Chayama K. Murashima N. Ikeda K, and Kumada H, Lamivudine therapy for spontaneously occurring severe acute exacerbation in chronic hepatitis B virus infection: a preliminary study. Am J Gastroenterol, 2001; 96: 557-62.

  • Higashi Y. Sanada M. Sasaki S. Nakagawa K. Goto C. Matsuura H. Ohama K. Chayama K, and Oshima T, Effect of estrogen replacement therapy on endothelial function in peripheral resistance arteries in normotensive and hypertensive postmenopausal women. Hypertension, 2001; 37: 651-7.

  • Someya T. Suzuki Y. Arase Y. Kobayashi M. Suzuki F. Tsubota A. Saitoh S. Chayama K. Murashima N. Ikeda K, and Kumada H, Interferon therapy for flare-up of hepatitis B virus infection after emergence of lamivudine-induced YMDD motif mutant. J Gastroenterol, 2001; 36: 133-6.

  • Arase Y. Ikeda K. Chayama K. Murashima N. Tsubota A. Suzuki Y. Saitoh S. Kobayashi M. Suzuki F, and Kumada H, Efficacy of IFN therapy based on duration period of negative HCV-RNA during IFN administration. Hepatol Res, 2001; 19: 22-30.

  • Sasaki T. Fujimoto Y. Tsuchida A. Kawasaki Y. Kuwada Y, and Chayama K, Activation of peroxisome proliferator-activated receptor gamma inhibits the growth of human pancreatic cancer. Pathobiology, 2001; 69: 258-65.

  • Matsutani N. Yokozaki H. Tahara E. Tahara H. Kuniyasu H. Kitadai Y. Haruma K. Chayama K, and Yasui W, Expression of MRE11 complex (MRE11, RAD50, NBS1) and hRap1 and its relation with telomere regulation, telomerase activity in human gastric carcinomas. Pathobiology, 2001; 69: 219-24.

  • Suzuki F. Chayama K. Tsubota A. Akuta N. Someya T. Kobayashi M. Suzuki Y. Saitoh S. Arase Y. Ikeda K, and Kumada H, Pathogenic significance and organic virus levels in patients infected with TT virus. Intervirology, 2001; 44: 291-7.

  • Tanaka S H K, Nagata S, Oka S, Chayama K., Diagnosis of invasion depth in early colorectal carcinoma by pit pattern analysis with magnifying endoscopy. Digestive Endoscopy, 2001; 13: S2-S5.

  • Kitadai Y H K, Goto T, Komoto K, Tanaka S, Yoshihara M, Sumii K, Chayama K., Gastric Carcinoma and Helicobacter pylori Infection: Role of Nitric Oxide and Inflammatory Cytokines in Gastric Carcinogenesis. Trends in Gastroenterology and Hepatology, 2001 82-85

  • Oue N. Sentani K. Yokozaki H. Kitadai Y. Ito R, and Yasui W, Promoter methylation status of the DNA repair genes hMLH1 and MGMT in gastric carcinoma and metaplastic mucosa. Pathobiology, 2001; 69: 143-9.

  • Higashi Y M H, Kajiyama G, Oshima T, Chayama K., Effect of for antihypertensives on reactive hypermia in essential hypertension. Cardiology Review, 2001; 18: 31-39.

  • Matsuura H I Y, Shimada K, Kuwajima I, Abe K., Effects of the long-acting calcium channel blocker barnidipine hydrochloride on 24-h ambulatory blood pressure:results of the Japanese Multicenter study on Barnidipine with Ambulatory Blood Pressure monitoring. Blood Press Monit, 2001; 6: S41-S46.