広島大学大学院医歯薬保健学研究科

消化器⋅代謝内科学

(広島大学病院 旧第一内科)

業績・活動

主要業績

主要業績

  • Oshiro T. Koyama S. Sugiyama S. Kondo A. Onodera Y. Asahara T. Sabe H, and Kikuchi A, Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration. J Biol Chem, 2002; 277: 38618-26.

  • Takahashi Y. Kitadai Y. Ellis L M. Bucana C D. Fidler I J, and Mai M, Multiparametric in situ mRNA hybridization analysis of gastric biopsies predicts lymph node metastasis in patients with gastric carcinoma. Jpn J Cancer Res, 2002; 93: 1258-65.

  • Tari A. Kodama K. Kurihara K. Fujihara M. Sumii K, and Kajiyama G, Does serum nitrite concentration reflect gastric carcinogenesis in Japanese Helicobacter pylori-infected patients? Dig Dis Sci, 2002; 47: 100-6.

  • Higashi Y. Nakagawa K. Kimura M. Noma K. Hara K. Sasaki S. Goto C. Oshima T. Chayama K, and Yoshizumi M, Circadian variation of blood pressure and endothelial function in patients with essential hypertension:a comparison of dippers and non-dippers. J Am Coll Cardiol, 2002; 40: 2039-43.

  • Teragawa H. Matsuura H. Chayama K, and Oshima T, Mechanisms responsible for vasodilation upon magnesium infusion in vivo: clinical evidence. Magnes Res, 2002; 15: 241-6.

  • Nakano Y. Ishida T. Ozono R. Matsuura H. Yamamoto Y. Kambe M. Chayama K, and Oshima T, A frameshift mutation of beta subunit of epithelial sodium channel in a case of isolated Liddle syndrome. J Hypertens, 2002; 20: 2379-82.

  • Ohta M. Kitadai Y. Tanaka S. Yoshihara M. Yasui W. Mukaida N. Haruma K, and Chayama K, Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human esophageal squamous cell carcinomas. Int J Cancer, 2002; 102: 220-4.

  • Miyamoto M. Haruma K. Yoshihara M. Sumioka M. Nishisaka T. Tanaka S. Inoue K, and Chayama K, Five cases of nodular gastritis and gastric cancer: a possible association between nodular gastritis and gastric cancer. Dig Liver Dis, 2002; 34: 819-20.

  • Kawasaki Y. Tsuchida A. Sasaki T. Yamasaki S. Kuwada Y. Murakami M, and Chayama K, Irsogladine malate up-regulates gap junctional intercellular communication between pancreatic cancer cells via PKA pathway. Pancreas, 2002; 25: 373-7.

  • Teragawa H. Fukuda Y. Matsuda K. Higashi Y. Yamagata T. Matsuura H, and Chayama K, Effect of alcohol consumption on endothelial function in men with coronary artery disease. Atherosclerosis, 2002; 165: 145-52.

  • Oka S. Tanaka S. Hiyama T. Kitadai Y. Yoshihara M. Shimamoto F. Haruma K, and Chayama K, Human telomerase reverse transcriptase, p53 and Ki-67 expression and apoptosis in colorectal serrated adenoma. Scand J Gastroenterol, 2002; 37: 1194-200.

  • Sanada M. Higashi Y. Nakagawa K. Tsuda M. Kodama I. Kimura M. Chayama K, and Ohama K, Hormone replacement effects on endothelial function measured in the forearm resistance artery in normocholesterolemic and hypercholesterolemic postmenopausal women. J Clin Endocrinol Metab, 2002; 87: 4634-41.

  • Tanaka S. Nagata S. Oka S. Kuwai T. Tamura T. Kitadai Y. Sumii M. Yoshihara M. Haruma K, and Chayama K, Determining depth of invasion by VN pit pattern analysis in submucosal colorectal carcinoma. Oncol Rep, 2002; 9: 1005-8.

  • Sanada M. Higashi Y. Nakagawa K. Tsuda M. Kodama I. Nagai N. Chayama K, and Ohama K, Combination therapy of low-dose medroxyprogesterone acetate and oral estrogen does not affect endothelial function in the forearms of postmenopausal women. Menopause, 2002; 9: 360-6.

  • Sakai K. Yamagata T. Teragawa H. Matsuura H, and Chayama K, Nicorandil-induced preconditioning as evidenced by troponin T measurements after coronary angioplasty in patients with stable angina pectoris. Jpn Heart J, 2002; 43: 443-53.

  • Kamada K. Kitamoto M. Aikata H. Kawakami Y. Kono H. Imamura M. Nakanishi T, and Chayama K, Combination of transcatheter arterial chemoembolization using cisplatin-lipiodol suspension and percutaneous ethanol injection for treatment of advanced small hepatocellular carcinoma. Am J Surg, 2002; 184: 284-90.

  • Manabe N. Yoshihara M. Sasaki A. Tanaka S. Haruma K, and Chayama K, Clinical characteristics and natural history of patients with low-grade reflux esophagitis. J Gastroenterol Hepatol, 2002; 17: 949-54.

  • Ito M. Haruma K. Kamada T. Mihara M. Kim S. Kitadai Y. Sumii M. Tanaka S. Yoshihara M, and Chayama K, Helicobacter pylori eradication therapy improves atrophic gastritis and intestinal metaplasia: a 5-year prospective study of patients with atrophic gastritis. Aliment Pharmacol Ther, 2002; 16: 1449-56.

  • Nagata S. Tanaka S. Haruma K. Kitadai Y. Yoshihara M. Shimamoto F, and Chayama K, Advanced colorectal carcinoma smaller than 10 mm in maximum diameter with special reference to clinicopathologic and molecular features: a report of 3 cases. Gastrointest Endosc, 2002; 56: 299-303.

  • Hiyama T. Tanaka S. Kitadai Y. Ito M. Sumii M. Yoshihara M. Shimamoto F. Haruma K, and Chayama K, p53 Codon 72 polymorphism in gastric cancer susceptibility in patients with Helicobacter pylori-associated chronic gastritis. Int J Cancer, 2002; 100: 304-8.

  • Sakai K. Yamagata T. Teragawa H. Matsuura H, and Chayama K, Preconditioning effect during coronary angioplasty in patients with stable angina pectoris. Intern Med, 2002; 41: 509-15.

  • Amioka T. Kitadai Y. Tanaka S. Haruma K. Yoshihara M. Yasui W, and Chayama K, Vascular endothelial growth factor-C expression predicts lymph node metastasis of human gastric carcinomas invading the submucosa. Eur J Cancer, 2002; 38: 1413-9.

  • Higashi Y. Sasaki S. Nakagawa K. Matsuura H. Oshima T, and Chayama K, Endothelial function and oxidative stress in renovascular hypertension. N Engl J Med, 2002; 346: 1954-62.

  • Manabe N. Haruma K. Hata J. Kusunoki H. Yoshida S. Futagami K. Tanaka S, and Chayama K, Evaluation of esophageal motility by endosonography using a miniature ultrasonographic probe in patients with reflux esophagitis. Scand J Gastroenterol, 2002; 37: 674-8.

  • Aoki S. Haruma K. Kusunoki H. Hata J. Hara M. Yoshida S. Tanaka S, and Chayama K, Evaluation of gastric emptying measured with the 13C-octanoic acid breath test in patients with functional dyspepsia: comparison with ultrasonography. Scand J Gastroenterol, 2002; 37: 662-6.

  • Onogawa S. Tanaka S. Oka S. Morihara M. Kitadai Y. Sumii M. Yoshihara M. Shimamoto F. Haruma K, and Chayama K, Clinical significance of angiogenesis in rectal carcinoid tumors. Oncol Rep, 2002; 9: 489-94.

  • Okanobu H. Hata J. Haruma K. Matsumura S. Yoshida S. Kitadai Y. Tanaka S, and Chayama K, Preoperative assessment of gastric cancer vascularity by flash echo imaging. Scand J Gastroenterol, 2002; 37: 608-12.

  • Ito M. Haruma K. Kaya S. Kai H. Masuda H. Ohta M. Sumii M. Tanaka S. Yoshihara M, and Chayama K, Implication of anti-parietal cell antibody levels in gastrointestinal diseases, including gastric carcinogenesis. Dig Dis Sci, 2002; 47: 1080-5.

  • Higashi Y. Sasaki S. Nakagawa K. Kimura M. Noma K. Hara K. Matsuura H. Goto C. Oshima T, and Chayama K, Severity of hypertension affects improved resistance artery endothelial function by angiotensin-converting enzyme inhibition. J Cardiovasc Pharmacol, 2002; 39: 668-76.

  • Kitamoto M. Imamura M. Kamada K. Aikata H. Kawakami Y. Matsumoto A. Kurihara Y. Kono H. Shirakawa H. Nakanishi T. Ito K, and Chayama K, Balloon-occluded retrograde transvenous obliteration of gastric fundal varices with hemorrhage. AJR Am J Roentgenol, 2002; 178: 1167-74.

  • Haruma K. Ito M. Kido S. Manabe N. Kitadai Y. Sumii M. Tanaka S. Yoshihara M, and Chayama K, Long-term rebamipide therapy improves Helicobacter pylori-associated chronic gastritis. Dig Dis Sci, 2002; 47: 862-7.

  • Higashi Y. Sasaki S. Nakagawa K. Fukuda Y. Matsuura H. Oshima T, and Chayama K, Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals. Am J Hypertens, 2002; 15: 326-32.

  • Sasaki S. Higashi Y. Nakagawa K. Kimura M. Noma K. Hara K. Matsuura H. Goto C. Oshima T, and Chayama K, A low-calorie diet improves endothelium-dependent vasodilation in obese patients with essential hypertension. Am J Hypertens, 2002; 15: 302-9.

  • Miyamoto M. Haruma K. Hiyama T. Kamada T. Masuda H. Shimamoto F. Inoue K, and Chayama K, High incidence of B-cell monoclonality in follicular gastritis: a possible association between follicular gastritis and MALT lymphoma. Virchows Arch, 2002; 440: 376-80.

  • Sakai K. Yamagata T. Teragawa H. Matsuura H, and Chayama K, Nicorandil enhances myocardial tolerance to ischemia without progressive collateral recruitment during coronary angioplasty. Circ J, 2002; 66: 317-22.

  • Nakagawa K. Higashi Y. Sasaki S. Oshima T. Matsuura H, and Chayama K, Leptin causes vasodilation in humans. Hypertension Research, 2002; 25: 161-5.

  • Ito M. Haruma K. Kaya S. Kamada T. Kim S. Sasaki A. Sumii M. Tanaka S. Yoshihara M, and Chayama K, Role of anti-parietal cell antibody in Helicobacter pylori-associated atrophic gastritis: evaluation in a country of high prevalence of atrophic gastritis. Scand J Gastroenterol, 2002; 37: 287-93.

  • Nakamura M. Haruma K. Kamada T. Mihara M. Yoshihara M. Sumioka M. Fukuhara T, and Chayama K, Cigarette smoking promotes atrophic gastritis in Helicobacter pylori-positive subjects. Dig Dis Sci, 2002; 47: 675-81.

  • Fukuda Y. Teragawa H. Matsuda K. Yamagata T. Matsuura H, and Chayama K, Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia. Heart, 2002; 87: 264-9.

  • Nakano Y. Oshima T. Ozono R. Ueda A. Oue Y. Matsuura H. Sanada M. Ohama K. Chayama K, and Kambe M, Estrogen replacement suppresses function of thrombin stimulated platelets by inhibiting Ca(2+) influx and raising cyclic adenosine monophosphate. Cardiovasc Res, 2002; 53: 634-41.

  • Sakomoto M. Tazuma S, and Chayama K, Less hydrophobic phosphatidylcholine species simplify biliary vesicle morphology, but induce bile metastability with a broad spectrum of crystal forms. Biochem J, 2002; 362: 105-12.

  • Hiyama T. Haruma K. Kitadai Y. Masuda H. Miyamoto M. Tanaka S. Yoshihara M. Shimamoto F, and Chayama K, K-ras mutation in helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer. Int J Cancer, 2002; 97: 562-6.

  • Kodama K. Sumii K. Kawano M. Kido T. Nojima K. Sumii M. Haruma K. Yoshihara M, and Chayama K, Helicobacter pylori infection increases serum nitrate and nitrite more prominently than serum pepsinogens. Helicobacter, 2002; 7: 9-13.

  • Ito M. Haruma K. Kaya S. Kamada T. Kim S. Sasaki A. Sumii M. Tanaka S. Yoshihara M. Wagner S, and Chayama K, Serological comparison of serum pepsinogen and anti-parietal cell antibody levels between Japanese and German patients. Eur J Gastroenterol Hepatol, 2002; 14: 123-7.

  • Higashi Y. Sasaki S. Nakagawa K. Kimura M. Noma K. Matsuura H. Hara K. Goto C. Oshima T, and Chayama K, Excess norepinephrine impairs both endothelium-dependent and -independent vasodilation in patients with pheochromocytoma. Hypertension, 2002; 39: 513-8.

  • Higashi Y and Chayama K, Renal endothelial dysfunction and hypertension. J Diabetes Complications, 2002; 16: 103-7.

  • Fukuda Y. Teragawa H. Matsuda K. Yamagata T. Matsuura H, and Chayama K, Tetrahydrobiopterin improves coronary endothelial function, but does not prevent coronary spasm in patients with vasospastic angina. Circ J, 2002; 66: 58-62.

  • Tazuma S and Chayama K, [Hepatitis C]. Nihon Rinsho, 2002; 60 Suppl 1: 213-9.

  • Ito M. Tanaka S. Yoshihara M. Chayama K, and Haruma K, Single administration of ecabet sodium diminishes the level of delta-13CO2 in urea breath test. J Gastroenterol, 2002; 37: 674-5.

  • Chayama K, Management of chronic hepatitis C and prevention of hepatocellular carcinoma. J Gastroenterol, 2002; 37 Suppl 13: 69-73.

  • Furudoi A. Tanaka S. Haruma K. Kitadai Y. Yoshihara M. Chayama K, and Shimamoto F, Clinical significance of vascular endothelial growth factor C expression and angiogenesis at the deepest invasive site of advanced colorectal carcinoma. Oncology, 2002; 62: 157-66.

  • Tari A. Kawano M. Kodama K. Yonei Y. Okahara S. Haruma K. Sumii K, and Kajiyama G, The effects of rabeprazole on parietal cells and enterochromaffin-like cells in rats: a comparison with omeprazole. J Gastroenterol, 2002; 37: 177-85.

  • Takeo E. Yoshida H. Tada N. Shingu T. Matsuura H. Murata Y. Yoshikawa S. Ishikawa T. Nakamura H. Ohsuzu F, and Kohda H, Sweet elements of Siraitia grosvenori inhibit oxidative modification of low-density lipoprotein. J Atheroscler Thromb, 2002; 9: 114-20.