広島大学大学院医歯薬保健学研究科

消化器⋅代謝内科学

(広島大学病院 旧第一内科)

業績・活動

主要業績

主要業績

  • Kuniyasu H. Ohmori H. Sasaki T. Sasahira T. Yoshida K. Kitadai Y, and Fidler I J, Production of interleukin 15 by human colon cancer cells is associated with induction of mucosal hyperplasia, angiogenesis, and metastasis. Clin Cancer Res, 2003; 9: 4802-10.

  • Oshima T. Ono N. Ozono R. Higashi Y. Ishida M. Ishida T. Miho N. Nakashima H. Yano Y, and Kambe M, Effect of amlodipine and cilazapril treatment on platelet Ca2+ handling in spontaneously hypertensive rats. Hypertens Res, 2003; 26: 901-6.

  • Tari A. Kodama K. Kitadai Y. Ohta M. Sumii K, and Kajiyama G, Is apoptosis in antral mucosa correlated with serum nitrite concentration in Japanese Helicobacter pylori-infected patients? J Gastroenterol Hepatol, 2003; 18: 498-504.

  • Oishi Y. Ozono R. Yano Y. Teranishi Y. Akishita M. Horiuchi M. Oshima T, and Kambe M, Cardioprotective role of AT2 receptor in postinfarction left ventricular remodeling. Hypertension, 2003; 41: 814-8.

  • Okura Y. Hayashi K. Shingu T. Kuga Y. Nomura S. Kajiyama G. Nakashima Y, and Saku K, Angiotensin-converting enzyme insertion/deletion genotype is associated with the activities of plasma coagulation factor VII and X independent of triglyceride metabolism. Coron Artery Dis, 2003; 14: 285-91.

  • Kamada T. Haruma K. Hata J. Kusunoki H. Sasaki A. Ito M. Tanaka S, and Yoshihara M, The long-term effect of Helicobacter pylori eradication therapy on symptoms in dyspeptic patients with fundic atrophic gastritis. Aliment Pharmacol Ther, 2003; 18: 245-52.

  • Haruma K and Ito M, Review article: clinical significance of mucosal-protective agents: acid, inflammation, carcinogenesis and rebamipide. Aliment Pharmacol Ther, 2003; 18 Suppl 1: 153-9.

  • Takenaka S. Nakamura N. Shiode N. Shirota K. Suyama H. Goto Y. Hirao H. Nakazawa Y. Inoue K, and Nagamatsu T, Five-year angiographic outcome in patients without restenosis following coronary balloon angioplasty: a comparison between non diabetic and diabetic lesions. Jpn Heart J, 2003; 44: 31-9.

  • Higashi Y and Yoshizumi M, New methods to evaluate endothelial function: method for assessing endothelial function in humans using a strain-gauge plethysmography: nitric oxide-dependent and -independent vasodilation. J Pharmacol Sci, 2003; 93: 399-404.

  • Kuraoka K. Oue N. Yokozaki H. Kitadai Y. Ito R. Nakayama H, and Yasui W, Correlation of a single nucleotide polymorphism in the E-cadherin gene promoter with tumorigenesis and progression of gastric carcinoma in Japan. Int J Oncol, 2003; 23: 421-7.

  • Matsuda K. Teragawa H. Fukuda Y. Ueda K. Higashi Y. Sakai K. Miura F. Hirao H. Yamagata T. Yoshizumi M, and Chayama K, Response of the left anterior descending coronary artery to acetylcholine in patients with chest pain and angiographically normal coronary arteries. Am J Cardiol, 2003; 92: 1394-8.

  • Ishida M. Ishida T. Nakashima H. Miho N. Miyagawa K. Chayama K. Oshima T. Kambe M, and Yoshizumi M, Mnk1 is required for angiotensin II-induced protein synthesis in vascular smooth muscle cells. Circ Res, 2003; 93: 1218-24.

  • Komichi D. Tazuma S. Nishioka T. Hyogo H. Une M, and Chayama K, Unique inhibition of bile salt-induced apoptosis by lecithins and cytoprotective bile salts in immortalized mouse cholangiocytes. Dig Dis Sci, 2003; 48: 2315-22.

  • Oshimo Y. Nakayama H. Ito R. Kitadai Y. Yoshida K. Chayama K, and Yasui W, Promoter methylation of cyclin D2 gene in gastric carcinoma. Int J Oncol, 2003; 23: 1663-70.

  • Kitadai Y. Sasaki A. Ito M. Tanaka S. Oue N. Yasui W. Aihara M. Imagawa K. Haruma K, and Chayama K, Helicobacter pylori infection influences expression of genes related to angiogenesis and invasion in human gastric carcinoma cells. Biochem Biophys Res Commun, 2003; 311: 809-14.

  • Oka S. Tanaka S. Nagata S. Hiyama T. Ito M. Kitadai Y. Yoshihara M. Haruma K, and Chayama K, Clinicopathologic features and endoscopic resection of early primary nonampullary duodenal carcinoma. J Clin Gastroenterol, 2003; 37: 381-6.

  • Hiyama T. Tanaka S. Shima H. Kose K. Tuncel H. Ito M. Kitadai Y. Sumii M. Yoshihara M. Shimamoto F. Haruma K, and Chayama K, Somatic mutation in mitochondrial DNA and nuclear microsatellite instability in gastric cancer. Oncol Rep, 2003; 10: 1837-41.

  • Ueda A. Ozono R. Oshima T. Yano A. Kambe M. Teranishi Y. Katsuki M, and Chayama K, Disruption of the type 2 dopamine receptor gene causes a sodium-dependent increase in blood pressure in mice. Am J Hypertens, 2003; 16: 853-8.

  • Hiyama T. Tanaka S. Masuda H. Shima H. Kose K. Tuncel H. Ito M. Kitadai Y. Sumii M. Uemura N. Yoshihara M. Shimamoto F. Haruma K, and Chayama K, Prevalence of Helicobacter pylori resistance to clarithromycin and metronidazole determined by 23S ribosomal RNA and rdxA gene analyses in Hiroshima, Japan. J Gastroenterol Hepatol, 2003; 18: 1202-7.

  • Kuwai T. Tanaka S. Kaio E. Hiyama T. Ito M. Kitadai Y. Sumii M. Yoshihara M. Haruma K, and Chayama K, Clinical significance of Fhit expression in development of colorectal carcinoma of various macroscopic types. Int J Mol Med, 2003; 12: 437-42.

  • Kaio E. Tanaka S. Oka S. Hiyama T. Kitadai Y. Haruma K, and Chayama K, Clinical significance of thrombospondin-1 expression in relation to vascular endothelial growth factor and interleukin-10 expression at the deepest invasive tumor site of advanced colorectal carcinoma. Int J Oncol, 2003; 23: 901-11.

  • Matsumura S. Oue N. Ito R. Nakayama H. Kitadai Y. Yokozaki H. Chayama K, and Yasui W, The promoter methylation status of the DNA repair gene O6-methylguanine-DNA methyltransferase in ulcerative colitis. Virchows Arch, 2003; 443: 518-23.

  • Hiyama T. Tanaka S. Shima H. Kose K. Kitadai Y. Ito M. Sumii M. Yoshihara M. Shimamoto F. Haruma K, and Chayama K, Frequent loss of heterozygosity on chromosome 10p15, a putative telomerase repressor/senescence gene locus, in gastric cancer. Oncol Rep, 2003; 10: 1297-9.

  • Murakami M. Sasaki T. Kuwada Y. Yamasaki S. Kuwahara K, and Chayama K, Prognostic value of p53 and Ki-67 expression in resected or biopsy specimens of bile duct carcinoma. Oncol Rep, 2003; 10: 1091-6.

  • Tari A. Kodama K. Sumii M. Tani H. Sumii K, and Chayama K, Does intragastric nitrite concentration reflect gastric carcinogenesis in Japanese Helicobacter pylori-infected patients? Dig Dis Sci, 2003; 48: 1730-6.

  • Masuda H. Hiyama T. Yoshihara M. Tanaka S. Shimamoto F. Haruma K, and Chayama K, Necessity of multiple gastric biopsies from different sites for detection of clarithromycin-resistant Helicobacter pylori strains. Scand J Gastroenterol, 2003; 38: 942-6.

  • Kodama K. Sumii K. Kawano M. Kido T. Nojima K. Sumii M. Haruma K. Yoshihara M, and Chayama K, Gastric juice nitrite and vitamin C in patients with gastric cancer and atrophic gastritis: is low acidity solely responsible for cancer risk? Eur J Gastroenterol Hepatol, 2003; 15: 987-93.

  • Hiyama T. Tanaka S. Masuda H. Shima H. Kose K. Tuncel H. Ito M. Kitadai Y. Sumii M. Uemura N. Yoshihara M. Shimamoto F. Haruma K, and Chayama K, p53 expression, K-ras gene mutation and microsatellite instability in gastric B-cell lymphomas. J Gastroenterol Hepatol, 2003; 18: 1047-53.

  • Kanno K. Tazuma S, and Chayama K, AT1A-deficient mice show less severe progression of liver fibrosis induced by CCl(4). Biochem Biophys Res Commun, 2003; 308: 177-83.

  • Goto C. Higashi Y. Kimura M. Noma K. Hara K. Nakagawa K. Kawamura M. Chayama K. Yoshizumi M, and Nara I, Effect of different intensities of exercise on endothelium-dependent vasodilation in humans: role of endothelium-dependent nitric oxide and oxidative stress. Circulation, 2003; 108: 530-5.

  • Ohishi W. Kitamoto M. Aikata H. Kamada K. Kawakami Y. Ishihara H. Kamiyasu M. Nakanishi T. Tazuma S, and Chayama K, Impact of aging on the development of hepatocellular carcinoma in patients with hepatitis C virus infection in Japan. Scand J Gastroenterol, 2003; 38: 894-900.

  • Teragawa H. Fukuda Y. Matsuda K. Hirao H. Higashi Y. Yamagata T. Oshima T. Matsuura H, and Chayama K, Myocardial bridging increases the risk of coronary spasm. Clin Cardiol, 2003; 26: 377-83.

  • Hiyama T. Tanaka S. Shima H. Kose K. Kitadai Y. Ito M. Sumii M. Yoshihara M. Shimamoto F. Haruma K, and Chayama K, Somatic mutation of mitochondrial DNA in Helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer. Int J Mol Med, 2003; 12: 169-74.

  • Higashi Y. Sasaki S. Nakagawa K. Kimura M. Noma K. Hara K. Matsuura H. Goto C. Oshima T. Chayama K, and Yoshizumi M, Low body mass index is a risk factor for impaired endothelium-dependent vasodilation in humans: role of nitric oxide and oxidative stress. J Am Coll Cardiol, 2003; 42: 256-63.

  • Kido T. Sumii K. Kawano M. Sumii M. Yoshihara M, and Chayama K, Food deprivation enhances somatostatin and somatostatin receptor subtype expression in rat colon. Regul Pept, 2003; 114: 167-73.

  • Asada N. Tanaka Y. Hayashido Y. Toratani S. Kan M. Kitamoto M. Nakanishi T. Kajiyama G. Chayama K, and Okamoto T, Expression of fibroblast growth factor receptor genes in human hepatoma-derived cell lines. In Vitro Cell Dev Biol Anim, 2003; 39: 321-8.

  • Takahashi R. Tanaka S. Hiyama T. Ito M. Kitadai Y. Sumii M. Haruma K, and Chayama K, Hypoxia-inducible factor-1alpha expression and angiogenesis in gastrointestinal stromal tumor of the stomach. Oncol Rep, 2003; 10: 797-802.

  • Ito M. Tanaka S. Kim S. Kuwai T. Matsutani N. Kamada T. Kitadai Y. Sumii M. Yoshihara M. Haruma K, and Chayama K, The specific expression of hypoxia inducible factor-1alpha in human gastric mucosa induced by nonsteroidal anti-inflammatory drugs. Aliment Pharmacol Ther, 2003; 18 Suppl 1: 90-8.

  • Tanaka J. Kumada H. Ikeda K. Chayama K. Mizui M. Hino K. Katayama K. Kumagai J. Komiya Y. Miyakawa Y, and Yoshizawa H, Natural histories of hepatitis C virus infection in men and women simulated by the Markov model. J Med Virol, 2003; 70: 378-86.

  • Sasaki A. Haruma K. Manabe N. Tanaka S. Yoshihara M, and Chayama K, Long-term observation of reflux oesophagitis developing after Helicobacter pylori eradication therapy. Aliment Pharmacol Ther, 2003; 17: 1529-34.

  • Nakai K. Tazuma S. Nishioka T, and Chayama K, Inhibition of cholesterol crystallization under bilirubin deconjugation: partial characterization of mechanisms whereby infected bile accelerates pigment stone formation. Biochim Biophys Acta, 2003; 1632: 48-54.

  • Kuwai T. Kitadai Y. Tanaka S. Onogawa S. Matsutani N. Kaio E. Ito M, and Chayama K, Expression of hypoxia-inducible factor-1alpha is associated with tumor vascularization in human colorectal carcinoma. Int J Cancer, 2003; 105: 176-81.

  • Kanno K. Tazuma S. Niida S, and Chayama K, Unique reciprocal changes of hepatocellular membrane transporter expression and fluidity in rats with selective biliary obstruction. Hepatol Res, 2003; 26: 157-163.

  • Miyamoto M. Haruma K. Yoshihara M. Hiyama T. Sumioka M. Nishisaka T. Tanaka S, and Chayama K, Nodular gastritis in adults is caused by Helicobacter pylori infection. Dig Dis Sci, 2003; 48: 968-75.

  • Kuwahara K. Sasaki T. Kuwada Y. Murakami M. Yamasaki S, and Chayama K, Expressions of angiogenic factors in pancreatic ductal carcinoma: a correlative study with clinicopathologic parameters and patient survival. Pancreas, 2003; 26: 344-9.

  • Kimura M. Higashi Y. Hara K. Noma K. Sasaki S. Nakagawa K. Goto C. Oshima T. Yoshizumi M, and Chayama K, PDE5 inhibitor sildenafil citrate augments endothelium-dependent vasodilation in smokers. Hypertension, 2003; 41: 1106-10.

  • Noma K. Higashi Y. Jitsuiki D. Hara K. Kimura M. Nakagawa K. Goto C. Oshima T. Yoshizumi M, and Chayama K, Smoking activates rho-kinase in smooth muscle cells of forearm vasculature in humans. Hypertension, 2003; 41: 1102-5.

  • Sanada M. Higashi Y. Nakagawa K. Kodama I. Tsuda M. Nagai N. Chayama K, and Ohama K, Comparison of forearm endothelial function between premenopausal and postmenopausal women with or without hypercholesterolemia. Maturitas, 2003; 44: 307-15.

  • Kamada T. Haruma K. Kusunoki H. Miyamoto M. Ito M. Kitadai Y. Yoshihara M. Chayama K. Tahara K, and Kawamura Y, Significance of an exaggerated meal-stimulated gastrin response in pathogenesis of Helicobacter pylori-negative duodenal ulcer. Dig Dis Sci, 2003; 48: 644-51.

  • Shima H. Tanaka S. Kuwai T. Hiyama T. Kitadai Y. Sumii M. Yoshihara M. Haruma K, and Chayama K, Minute depressed colon cancer with submucosal invasion. Gastrointest Endosc, 2003; 57: 564-5.

  • Ohta M. Kitadai Y. Tanaka S. Yoshihara M. Yasui W. Mukaida N. Haruma K, and Chayama K, Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human gastric carcinomas. Int J Oncol, 2003; 22: 773-8.

  • Kuwada Y. Sasaki T. Morinaka K. Kitadai Y. Mukaida N, and Chayama K, Potential involvement of IL-8 and its receptors in the invasiveness of pancreatic cancer cells. Int J Oncol, 2003; 22: 765-71.

  • Yoshida K. Ueno S. Iwao T. Yamasaki S. Tsuchida A. Ohmine K. Ohki R. Choi Y L. Koinuma K. Wada T. Ota J. Yamashita Y. Chayama K. Sato K, and Mano H, Screening of genes specifically activated in the pancreatic juice ductal cells from the patients with pancreatic ductal carcinoma. Cancer Sci, 2003; 94: 263-70.

  • Yamaguchi A. Tazuma S. Ochi H, and Chayama K, Choleretic action of diosgenin is based upon the increases in canalicular membrane fluidity and transporter activity mediating bile acid independent bile flow. Hepatol Res, 2003; 25: 287-295.

  • Sanada M. Higashi Y. Nakagawa K. Tsuda M. Kodama I. Kimura M. Chayama K, and Ohama K, A comparison of low-dose and standard-dose oral estrogen on forearm endothelial function in early postmenopausal women. J Clin Endocrinol Metab, 2003; 88: 1303-9.

  • Okanobu H. Hata J. Haruma K. Hara M. Nakamura K. Tanaka S, and Chayama K, Giant gastric folds: differential diagnosis at US. Radiology, 2003; 226: 686-90.

  • Noda T. Shimizu W. Tanaka K, and Chayama K, Prominent J wave and ST segment elevation: serial electrocardiographic changes in accidental hypothermia. J Cardiovasc Electrophysiol, 2003; 14: 223.

  • Manabe N. Haruma K. Hata J. Nakamura K. Tanaka S, and Chayama K, Autonomic nerve dysfunction is closely associated with the abnormalities of esophageal motility in reflux esophagitis. Scand J Gastroenterol, 2003; 38: 159-63.

  • Sasaki A. Kitadai Y. Ito M. Sumii M. Tanaka S. Yoshihara M. Haruma K, and Chayama K, Helicobacter pylori infection influences tumor growth of human gastric carcinomas. Scand J Gastroenterol, 2003; 38: 153-8.

  • Matsuda K. Teragawa H. Fukuda Y. Nakagawa K. Higashi Y, and Chayama K, Leptin causes nitric-oxide independent coronary artery vasodilation in humans. Hypertension Research, 2003; 26: 147-52.

  • Onogawa S. Tanaka S. Kitadai Y. Sumii M. Yoshihara M. Shimamoto F. Haruma K, and Chayama K, Small rectal carcinoid with lymph node metastasis diagnosed prior to treatment. Eur J Gastroenterol Hepatol, 2003; 15: 195-7.

  • Tazuma S. Nishioka T. Ochi H. Hyogo H. Sunami Y. Nakai K. Tsuboi K. Asamoto Y. Sakomoto M. Numata Y. Kanno K. Yamaguchi A. Kobuke T. Komichi D. Nonaka Y, and Chayama K, Impaired gallbladder mucosal function in aged gallstone patients suppresses gallstone recurrence after successful extracorporeal shockwave lithotripsy. J Gastroenterol Hepatol, 2003; 18: 157-61.

  • Tsuboi K. Tazuma S. Ochi H, and Chayama K, Hydrophilic bile salts have a cytoprotective effect against cyclosporine A-induced cholestasis through enhanced canalicular membrane fluidity and transporter activity. Hepatol Res, 2003; 25: 38-47.

  • Kurisu S. Ozono R. Oshima T. Kambe M. Ishida T. Sugino H. Matsuura H. Chayama K. Teranishi Y. Iba O. Amano K, and Matsubara H, Cardiac angiotensin II type 2 receptor activates the kinin/NO system and inhibits fibrosis. Hypertension, 2003; 41: 99-107.

  • Sanomura M. Tanaka S. Ito M, and Chayama K, Depressed-type, early duodenal carcinoma (carcinoma in situ) treated by endoscopic mucosal resection. J Gastroenterol, 2003; 38: 813-5.

  • Miyamoto M. Haruma K. Yoshihara M. Sumioka M. Kamada T. Ito M. Masuda H. Nishisaka T. Tanaka S, and Chayama K, Isolated granulomatous gastritis successfully treated by Helicobacter pylori eradication: a possible association between granulomatous gastritis and Helicobacter pylori. J Gastroenterol, 2003; 38: 371-5.

  • Kiyohira K. Yoshihara M. Ito M. Haruma K. Tanaka S, and Chayama K, Serum pepsinogen concentration as a marker of Helicobacter pyloriinfection and the histologic grade of gastritis; evaluation of gastric mucosa by serum pepsinogen levels. J Gastroenterol, 2003; 38: 332-8.

  • Takahashi R. Tanaka S. Kitadai Y. Sumii M. Yoshihara M. Haruma K, and Chayama K, Expression of vascular endothelial growth factor and angiogenesis in gastrointestinal stromal tumor of the stomach. Oncology, 2003; 64: 266-74.

  • Kaio E. Tanaka S. Kitadai Y. Sumii M. Yoshihara M. Haruma K, and Chayama K, Clinical significance of angiogenic factor expression at the deepest invasive site of advanced colorectal carcinoma. Oncology, 2003; 64: 61-73.

  • Ohishi W and Chayama K, Rare quasispecies in the YMDD motif of hepatitis B virus detected by polymerase chain reaction with peptide nucleic acid clamping. Intervirology, 2003; 46: 355-61.

  • Kuniyasu H. Kitadai Y. Mieno H, and Yasui W, Helicobactor pylori infection is closely associated with telomere reduction in gastric mucosa. Oncology, 2003; 65: 275-82.

  • Oue N. Matsumura S. Nakayama H. Kitadai Y. Taniyama K. Matsusaki K, and Yasui W, Reduced expression of the TSP1 gene and its association with promoter hypermethylation in gastric carcinoma. Oncology, 2003; 64: 423-9.

  • Tanaka S O S, Nagata S, Ito M, Haruma K, Chayama K., Endoscopic Diagnosis and Treatment of Local Residual/Recurrent Lesions after Endoscopic Mucosal Resection for Early Colorectal Carcinoma. Digestive Endoscopy, 2003; 15: S36-S38.

  • Yoshida S H K, Tanaka S, Mitsuoka H, Hara M, Masuda H, Kamada T, Kusunoki H, Kitadai Y, Hata J, Hayakawa N, Chayama K., Endoscopic ultrasonography for assessment of medical treatment in patients with gastric mucosa-associated lymphoid tissue lymphoma. Digestive Endoscopy, 2003; 15: 174 -178.

  • A. Taguchi Y S, M. Sanada, Y. Higashi, M. Ohtsuka, T. Nakamoto, M. Tsuda, K. Ohama, K. Tanimoto, Detection of Vascular Disease Risk in Women by Panoramic Radiography. J Dental Research, 2003; 82: 838-843.