広島大学大学院医歯薬保健学研究科

消化器⋅代謝内科学

(広島大学病院 旧第一内科)

業績・活動

主要業績

主要業績

  • Hansen J E. Sun X G. Yasunobu Y. Garafano R P. Gates G. Barst R J, and Wasserman K, Reproducibility of cardiopulmonary exercise measurements in patients with pulmonary arterial hypertension. Chest, 2004; 126: 816-24.

  • Sanada M. Taguchi A. Higashi Y. Tsuda M. Kodama I. Yoshizumi M, and Ohama K, Forearm endothelial function and bone mineral loss in postmenopausal women. Atherosclerosis, 2004; 176: 387-92.

  • Sou T. Yukiko N. Tetsuji S. Kazuaki C. Katsuhiko I, and Taijiro S, Atrial contraction after surgical isolation of the left atrial posterior wall concomitant with mitral valve replacement. Circ J, 2004; 68: 204-7.

  • Taguchi A. Sanada M. Suei Y. Ohtsuka M. Lee K. Tanimoto K. Tsuda M. Ohama K. Yoshizumi M, and Higashi Y, Tooth loss is associated with an increased risk of hypertension in postmenopausal women. Hypertension, 2004; 43: 1297-300.

  • Takaki S. Tsubota A. Hosaka T. Akuta N. Someya T. Kobayashi M. Suzuki F. Suzuki Y. Saitoh S. Arase Y. Ikeda K, and Kumada H, Factors contributing to ribavirin dose reduction due to anemia during interferon alfa2b and ribavirin combination therapy for chronic hepatitis C. J Gastroenterol, 2004; 39: 668-73.

  • Tarta C. da Silva V D. Teixeira C R. Prolla J C. Meurer L. Neto C C, and Tanaka S, Digital image analysis and stereology of angiogenesis in polypoid and nonpolypoid colorectal adenomas. Anal Quant Cytol Histol, 2004; 26: 201-6.

  • Higashi Y and Yoshizumi M, Exercise and endothelial function: role of endothelium-derived nitric oxide and oxidative stress in healthy subjects and hypertensive patients. Pharmacol Ther, 2004; 102: 87-96.

  • Oshimo Y. Kuraoka K. Nakayama H. Kitadai Y. Yoshida K. Chayama K, and Yasui W, Epigenetic inactivation of SOCS-1 by CpG island hypermethylation in human gastric carcinoma. Int J Cancer, 2004; 112: 1003-9.

  • Kunihiro M. Tanaka S. Sumii M. Ueno Y. Ito M. Kitadai Y. Yoshihara M. Shimamoto F. Haruma K, and Chayama K, Magnifying colonoscopic features of ulcerative colitis reflect histologic inflammation. Inflamm Bowel Dis, 2004; 10: 737-44.

  • Tsuda M. Sanada M. Higashi Y. Hara Y. Kodama I. Chayama K. Yoshizumi M, and Ohama K, Apolipoprotein E phenotype affects the malondialdehyde-modified LDL concentration and forearm endothelial function in postmenopausal women. Clin Endocrinol (Oxf) , 2004; 61: 619-25.

  • Kuwai T. Kitadai Y. Tanaka S. Kuroda T. Ochiumi T. Matsumura S. Oue N. Yasui W. Kaneyasu M. Tanimoto K. Nishiyama M, and Chayama K, Single nucleotide polymorphism in the hypoxia-inducible factor-1alpha gene in colorectal carcinoma. Oncol Rep, 2004; 12: 1033-7.

  • Jitsuiki D. Higashi Y. Goto C. Kimura M. Noma K. Hara K. Nakagawa K. Oshima T. Chayama K, and Yoshizumi M, Effect of edaravone, a novel free radical scavenger, on endothelium-dependent vasodilation in smokers. Am J Cardiol, 2004; 94: 1070-3.

  • Tsuboi K. Tazuma S. Nishioka T, and Chayama K, Partial characterization of cytoprotective mechanisms of lecithin against bile salt-induced bile duct damage. J Gastroenterol, 2004; 39: 955-60.

  • Tanaka T. Tanimoto K. Otani K. Satoh K. Ohtaki M. Yoshida K. Toge T. Yahata H. Tanaka S. Chayama K. Okazaki Y. Hayashizaki Y. Hiyama K, and Nishiyama M, Concise prediction models of anticancer efficacy of 8 drugs using expression data from 12 selected genes. Int J Cancer, 2004; 111: 617-26.

  • Miura F. Hirao H. Nakano Y. Teragawa H. Shingu T, and Chayama K, Improvement of atrial signal-averaged electrocardiographic abnormalities after radiofrequency catheter ablation in persistent atrial flutter. Jpn Heart J, 2004; 45: 761-70.

  • Shima H. Hiyama T. Tanaka S. Ito M. Kitadai Y. Yoshihara M. Arihiro K. Haruma K, and Chayama K, Frequent loss of heterozygosity on chromosome 10p14-p15 in esophageal dysplasia and squamous cell carcinoma. Oncol Rep, 2004; 12: 333-7.

  • Numata Y. Tazuma S. Nishioka T. Ueno Y, and Chayama K, Immune response in mouse experimental cholangitis associated with colitis induced by dextran sulfate sodium. J Gastroenterol Hepatol, 2004; 19: 910-5.

  • Kimura S. Kitadai Y. Tanaka S. Kuwai T. Hihara J. Yoshida K. Toge T, and Chayama K, Expression of hypoxia-inducible factor (HIF)-1alpha is associated with vascular endothelial growth factor expression and tumour angiogenesis in human oesophageal squamous cell carcinoma. Eur J Cancer, 2004; 40: 1904-12.

  • Hiyama T. Tanaka S. Yoshihara M. Sasao S. Kose K. Shima H. Tuncel H. Ueno Y. Ito M. Kitadai Y. Yasui W. Haruma K, and Chayama K, Chromosomal and microsatellite instability in sporadic gastric cancer. J Gastroenterol Hepatol, 2004; 19: 756-60.

  • Teragawa H. Fukuda Y. Matsuda K. Ueda K. Higashi Y. Oshima T. Yoshizumi M, and Chayama K, Relation between C reactive protein concentrations and coronary microvascular endothelial function. Heart, 2004; 90: 750-4.

  • Onogawa S. Kitadai Y. Tanaka S. Kuwai T. Kuroda T, and Chayama K, Regulation of vascular endothelial growth factor (VEGF)-C and VEGF-D expression by the organ microenvironment in human colon carcinoma. Eur J Cancer, 2004; 40: 1604-9.

  • Murakami M. Sasaki T. Yamasaki S. Kuwahara K. Miyata H, and Chayama K, Induction of apoptosis by ionizing radiation and CI-1033 in HuCCT-1 cells. Biochem Biophys Res Commun, 2004; 319: 114-9.

  • Kai H. Ito M. Kitadai Y. Tanaka S. Haruma K, and Chayama K, Chronic gastritis with expression of inducible nitric oxide synthase is associated with high expression of interleukin-6 and hypergastrinaemia. Aliment Pharmacol Ther, 2004; 19: 1309-14.

  • Oshimo Y. Oue N. Mitani Y. Nakayama H. Kitadai Y. Yoshida K. Chayama K, and Yasui W, Frequent epigenetic inactivation of RIZ1 by promoter hypermethylation in human gastric carcinoma. Int J Cancer, 2004; 110: 212-8.

  • Yoshida S. Tanaka S. Kamino D. Nakao M. Oka S. Kitadai Y. Hayakawa N. Haruma K, and Chayama K, Initial experience with catheter probe US when using a multibending endoscope. Gastrointest Endosc, 2004; 59: 889-94.

  • Murakami M. Sasaki T. Miyata H. Yamasaki S. Kuwahara K, and Chayama K, Fas and Fas ligand: Expression and soluble circulating levels in bile duct carcinoma. Oncol Rep, 2004; 11: 1183-6.

  • Matsumura S. Oue N. Kitadai Y. Chayama K. Yoshida K. Yamaguchi Y. Toge T. Imai K. Nakachi K, and Yasui W, A single nucleotide polymorphism in the MMP-1 promoter is correlated with histological differentiation of gastric cancer. J Cancer Res Clin Oncol, 2004; 130: 259-65.

  • Kunihiro K. Hata J. Haruma K. Manabe N. Tanaka S, and Chayama K, Sonographic detection of longitudinal ulcers in Crohn disease. Scand J Gastroenterol, 2004; 39: 322-6.

  • Kim S. Harum K. Ito M. Tanaka S. Yoshihara M, and Chayama K, Magnifying gastroendoscopy for diagnosis of histologic gastritis in the gastric antrum. Dig Liver Dis, 2004; 36: 286-91.

  • Ohishi W. Shirakawa H. Kawakami Y. Kimura S. Kamiyasu M. Tazuma S. Nakanishi T, and Chayama K, Identification of rare polymerase variants of hepatitis B virus using a two-stage PCR with peptide nucleic acid clamping. J Med Virol, 2004; 72: 558-65.

  • Higashi Y. Kimura M. Hara K. Noma K. Jitsuiki D. Nakagawa K. Oshima T. Chayama K. Sueda T. Goto C. Matsubara H. Murohara T, and Yoshizumi M, Autologous bone-marrow mononuclear cell implantation improves endothelium-dependent vasodilation in patients with limb ischemia. Circulation, 2004; 109: 1215-8.

  • Nakano Y. Niida S. Dote K. Takenaka S. Hirao H. Miura F. Ishida M. Shingu T. Sueda T. Yoshizumi M, and Chayama K, Matrix metalloproteinase-9 contributes to human atrial remodeling during atrial fibrillation. J Am Coll Cardiol, 2004; 43: 818-25.

  • Tsuji K. Watanabe Y. Kouno H. Aisaka Y. Masanaga T. Ishihara H. Kamiyasu M. Nakanishi T. Chayama K. Asahara T. Coppel R, and Gershwin M E, A case of latent primary biliary cirrhosis. Hepatol Res, 2004; 28: 166-169.

  • Ochiumi T. Tanaka S. Oka S. Hiyama T. Ito M. Kitadai Y. Haruma K, and Chayama K, Clinical significance of angiopoietin-2 expression at the deepest invasive tumor site of advanced colorectal carcinoma. Int J Oncol, 2004; 24: 539-47.

  • Kuwai T. Kitadai Y. Tanaka S. Hiyama T. Tanimoto K, and Chayama K, Mutation of the von Hippel-Lindau (VHL) gene in human colorectal carcinoma: association with cytoplasmic accumulation of hypoxia-inducible factor (HIF)-1alpha. Cancer Sci, 2004; 95: 149-53.

  • Oka S. Tanaka S. Hiyama T. Ito M. Kitadai Y. Yoshihara M. Haruma K, and Chayama K, Clinicopathologic and endoscopic features of colorectal serrated adenoma: differences between polypoid and superficial types. Gastrointest Endosc, 2004; 59: 213-9.

  • Kitadai Y. Onogawa S. Kuwai T. Matsumura S. Hamada H. Ito M. Tanaka S. Yoshihara M, and Chayama K, Angiogenic switch occurs during the precancerous stage of human esophageal squamous cell carcinoma. Oncol Rep, 2004; 11: 315-9.

  • Onogawa S. Kitadai Y. Tanaka S. Kuwai T. Kimura S, and Chayama K, Expression of VEGF-C and VEGF-D at the invasive edge correlates with lymph node metastasis and prognosis of patients with colorectal carcinoma. Cancer Sci, 2004; 95: 32-9.

  • Kuwahara K. Sasaki T. Kobayashi K. Noma B. Serikawa M. Iiboshi T. Miyata H. Kuwada Y. Murakami M. Yamasaki S. Kariya K. Morinaka K, and Chayama K, Gemcitabine suppresses malignant ascites of human pancreatic cancer: correlation with VEGF expression in ascites. Oncol Rep, 2004; 11: 73-80.

  • Amioka T. Kitadai Y. Hiyama T. Tanaka S. Yoshihara M. Haruma K, and Chayama K, Expression of human telomerase reverse transcriptase mRNA in esophageal cancers and precancerous lesions. Oncol Rep, 2004; 11: 51-5.

  • Sasaki A. Kitadai Y. Ito M. Tanaka S. Yoshihara M. Haruma K, and Chayama K, Mucin phenotype and background mucosa of intramucosal differentiated-type adenocarcinoma of the stomach. Oncology, 2004; 66: 379-87.

  • Masuda H. Hiyama T. Yoshihara M. Tanaka S. Haruma K, and Chayama K, Characteristics and trends of clarithromycin-resistant Helicobacter pylori isolates in Japan over a decade. Pathobiology, 2004; 71: 159-63.

  • Oshimo Y. Oue N. Mitani Y. Nakayama H. Kitadai Y. Yoshida K. Ito Y. Chayama K, and Yasui W, Frequent loss of RUNX3 expression by promoter hypermethylation in gastric carcinoma. Pathobiology, 2004; 71: 137-43.

  • S. Tanaka M I, The state-of-the-art of endoscopic treatment of colorectal stenosis in Japan: survey of participating institutions in endoscopy forum Japan. Digestive Endoscopy, 2004; 16: S64-S65.

  • S. Tanaka S Y, K. Chayama, Clinical usefulness of high-frequency ultrasound probes for new invasion depth diagnosis in submucosal colorectal carcinoma. Digestive Endoscopy, 2004; 16: S161-S164.