広島大学大学院医歯薬保健学研究科

消化器⋅代謝内科学

(広島大学病院 旧第一内科)

業績・活動

主要業績

主要業績

  • Yokoi K. Sasaki T. Bucana C D. Fan D. Baker C H. Kitadai Y. Kuwai T. Abbruzzese J L, and Fidler I J, Simultaneous inhibition of EGFR, VEGFR, and platelet-derived growth factor receptor signaling combined with gemcitabine produces therapy of human pancreatic carcinoma and prolongs survival in an orthotopic nude mouse model. Cancer Res, 2005; 65: 10371-80.

  • Oshima T. Ozono R. Yano Y. Higashi Y. Teragawa H. Miho N. Ishida T. Ishida M. Yoshizumi M, and Kambe M, Beneficial effect of T-type calcium channel blockers on endothelial function in patients with essential hypertension. Hypertens Res, 2005; 28: 889-94.

  • Bhoumik A. Takahashi S. Breitweiser W. Shiloh Y. Jones N, and Ronai Z, ATM-dependent phosphorylation of ATF2 is required for the DNA damage response. Mol Cell, 2005; 18: 577-87.

  • Yasunobu Y. Oudiz R J. Sun X G. Hansen J E, and Wasserman K, End-tidal PCO2 abnormality and exercise limitation in patients with primary pulmonary hypertension. Chest, 2005; 127: 1637-46.

  • Sano Y. Tanaka S. Teixeira C R, and Aoyama N, Endoscopic detection and diagnosis of 0-IIc neoplastic colorectal lesions. Endoscopy, 2005; 37: 261-7.

  • Hiraga N. Suzuki F. Akuta N. Suzuki Y. Sezaki H. Hosaka T. Someya T. Kobayashi M. Saitoh S. Arase Y. Ikeda K. Kobayashi M. Matsuda M. Watabiki S. Satoh J, and Kumada H, Clinical and virological characteristics of untreated patients with chronic hepatitis C who develop serum alanine aminotransferase flare-up. J Med Virol, 2005; 75: 240-8.

  • Scherubl H. Faiss S. Tschope R, and Zeitz M, Double-balloon enteroscopy for the detection of midgut carcinoids. Gastrointest Endosc, 2005; 62: 994; author reply 994-5.

  • Oshima T. Ozono R. Yano Y. Oishi Y. Teragawa H. Higashi Y. Yoshizumi M, and Kambe M, Association of Helicobacter pylori infection with systemic inflammation and endothelial dysfunction in healthy male subjects. J Am Coll Cardiol, 2005; 45: 1219-22.

  • Komichi D. Tazuma S. Nishioka T. Hyogo H, and Chayama K, Glycochenodeoxycholate plays a carcinogenic role in immortalized mouse cholangiocytes via oxidative DNA damage. Free Radic Biol Med, 2005; 39: 1418-27.

  • Katsumoto M. Shingu T. Kuwashima R. Nakata A. Nomura S, and Chayama K, Biphasic effect of HMG-CoA reductase inhibitor, pitavastatin, on vascular endothelial cells and angiogenesis. Circ J, 2005; 69: 1547-55.

  • Noma K. Goto C. Nishioka K. Hara K. Kimura M. Umemura T. Jitsuiki D. Nakagawa K. Oshima T. Chayama K. Yoshizumi M, and Higashi Y, Smoking, endothelial function, and Rho-kinase in humans. Arterioscler Thromb Vasc Biol, 2005; 25: 2630-5.

  • Kuroda T. Kitadai Y. Tanaka S. Yang X. Mukaida N. Yoshihara M, and Chayama K, Monocyte chemoattractant protein-1 transfection induces angiogenesis and tumorigenesis of gastric carcinoma in nude mice via macrophage recruitment. Clin Cancer Res, 2005; 11: 7629-36.

  • Miho N. Ishida T. Kuwaba N. Ishida M. Shimote-Abe K. Tabuchi K. Oshima T. Yoshizumi M, and Chayama K, Role of the JNK pathway in thrombin-induced ICAM-1 expression in endothelial cells. Cardiovasc Res, 2005; 68: 289-98.

  • Kose K. Hiyama T. Tanaka S. Yoshihara M. Yasui W, and Chayama K, Somatic mutations of mitochondrial DNA in digestive tract cancers. J Gastroenterol Hepatol, 2005; 20: 1679-84.

  • Kinoshita E. Kinoshita-Kikuta E. Kojima H. Nakano Y. Chayama K, and Koike T, Reliable and cost-effective screening of inherited heterozygosity by Zn2+-cyclen polyacrylamide gel electrophoresis. Clin Chem, 2005; 51: 2195-8.

  • Tsuge M. Hiraga N. Takaishi H. Noguchi C. Oga H. Imamura M. Takahashi S. Iwao E. Fujimoto Y. Ochi H. Chayama K. Tateno C, and Yoshizato K, Infection of human hepatocyte chimeric mouse with genetically engineered hepatitis B virus. Hepatology, 2005; 42: 1046-54.

  • Teragawa H. Ueda K. Matsuda K. Kimura M. Higashi Y. Oshima T. Yoshizumi M, and Chayama K, Relationship between endothelial function in the coronary and brachial arteries. Clin Cardiol, 2005; 28: 460-6.

  • Numata Y. Tazuma S. Ueno Y. Nishioka T. Hyogo H, and Chayama K, Therapeutic effect of repeated natural killer T cell stimulation in mouse cholangitis complicated by colitis. Dig Dis Sci, 2005; 50: 1844-51.

  • Ueda K. Teragawa H. Kimura M. Matsuda K. Higashi Y. Yamagata T. Oshima T. Yoshizumi M, and Chayama K, Adrenomedullin causes coronary vasodilation in humans: effects of inhibition of nitric oxide synthesis. J Cardiovasc Pharmacol, 2005; 46: 534-9.

  • Tsuge M. Hamamoto R. Silva F P. Ohnishi Y. Chayama K. Kamatani N. Furukawa Y, and Nakamura Y, A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancers. Nat Genet, 2005; 37: 1104-7.

  • Yoshida S. Tanaka S. Kunihiro K. Mitsuoka Y. Hara M. Kitadai Y. Hata J. Yoshihara M. Haruma K. Hayakawa N, and Chayama K, Diagnostic ability of high-frequency ultrasound probe sonography in staging early gastric cancer, especially for submucosal invasion. Abdom Imaging, 2005; 30: 518-23.

  • Nagata S. Tanaka S. Ito M. Yoshihara M. Haruma K, and Chayama K, Cardiac glands hyperplastic polyp of the stomach. J Gastroenterol Hepatol, 2005; 20: 1461-3.

  • Onogawa S. Kitadai Y. Amioka T. Kodama M. Cho S. Kuroda T. Ochiumi T. Kimura S. Kuwai T. Tanaka S, and Chayama K, Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in early gastric carcinoma: correlation with clinicopathological parameters. Cancer Lett, 2005; 226: 85-90.

  • Ito M. Tanaka S. Kim S. Tahara K. Kawamura Y. Sumii M. Takehara Y. Hayashi K. Okamoto E. Kunihiro M. Kunita T. Imagawa S. Takata S. Ueda H. Egi Y. Hiyama T. Ueno Y. Kitadai Y. Yoshihara M, and Chayama K, A combination of the Helicobacter pylori stool antigen test and urea breath test is useful for clinical evaluation of eradication therapy: a multicenter study. J Gastroenterol Hepatol, 2005; 20: 1241-5.

  • Takahashi S and Chayama K, Integration of hepatitis B virus DNA and hepatocellular carcinoma. J Gastroenterol Hepatol, 2005; 20: 1141-2.

  • Yamaguchi T. Manabe N. Tanaka S. Fukumoto A. Shimamoto M. Nakao M. Kamino D, and Chayama K, Multiple carcinoid tumors of the ileum preoperatively diagnosed by enteroscopy with the double-balloon technique. Gastrointest Endosc, 2005; 62: 315-8.

  • Yamaguchi A. Tazuma S. Nishioka T. Ohishi W. Hyogo H. Nomura S, and Chayama K, Hepatitis C virus core protein modulates fatty acid metabolism and thereby causes lipid accumulation in the liver. Dig Dis Sci, 2005; 50: 1361-71.

  • Kitadai Y. Kodama M. Cho S. Kuroda T. Ochiumi T. Kimura S. Tanaka S. Matsumura S. Yasui W, and Chayama K, Quantitative analysis of lymphangiogenic markers for predicting metastasis of human gastric carcinoma to lymph nodes. Int J Cancer, 2005; 115: 388-92.

  • Kamada T. Hata J. Kusunoki H. Sugiu K. Ito M. Tanaka S. Kawamura Y. Chayama K, and Haruma K, Effect of long-term half-dose famotidine therapy on corpus gastritis in peptic ulcer disease. Aliment Pharmacol Ther, 2005; 21 Suppl 2: 99-104.

  • Kamada T. Hata J. Kusunoki H. Kido S. Hamada H. Aoki R. Nishida T. Komoto K. Todo H. Sumioka M. Tanimoto T. Sanuki E. Sumii K. Ogoshi H. Hidaka T. Dongmei Q. Chayama K, and Haruma K, Effect of famotidine on recurrent bleeding after successful endoscopic treatment of bleeding peptic ulcer. Aliment Pharmacol Ther, 2005; 21 Suppl 2: 73-8.

  • Kamada T. Hata J. Sugiu K. Kusunoki H. Ito M. Tanaka S. Inoue K. Kawamura Y. Chayama K, and Haruma K, Clinical features of gastric cancer discovered after successful eradication of Helicobacter pylori: results from a 9-year prospective follow-up study in Japan. Aliment Pharmacol Ther, 2005; 21: 1121-6.

  • Kanno K. Tazuma S. Nishioka T. Hyogo H, and Chayama K, Angiotensin II participates in hepatic inflammation and fibrosis through MCP-1 expression. Dig Dis Sci, 2005; 50: 942-8.

  • Higashi Y. Chayama K, and Yoshizumi M, Angiotensin II type I receptor blocker and endothelial function in humans: role of nitric oxide and oxidative stress. Curr Med Chem Cardiovasc Hematol Agents, 2005; 3: 133-48.

  • Ueda K. Goto C. Jitsuiki D. Umemura T. Nishioka K. Kimura M. Noma K. Nakagawa K. Oshima T. Yoshizumi M. Chayama K, and Higashi Y, The nicorandil-induced vasodilation in humans is inhibited by miconazole. J Cardiovasc Pharmacol, 2005; 45: 290-4.

  • Ito M. Tanaka S. Takata S. Oka S. Imagawa S. Ueda H. Egi Y. Kitadai Y. Yasui W. Yoshihara M. Haruma K, and Chayama K, Morphological changes in human gastric tumours after eradication therapy of Helicobacter pylori in a short-term follow-up. Aliment Pharmacol Ther, 2005; 21: 559-66.

  • Kai H. Kitadai Y. Kodama M. Cho S. Kuroda T. Ito M. Tanaka S. Ohmoto Y, and Chayama K, Involvement of proinflammatory cytokines IL-1beta and IL-6 in progression of human gastric carcinoma. Anticancer Res, 2005; 25: 709-13.

  • Komichi D. Tazuma S. Nishioka T. Hyogo H, and Chayama K, A nuclear receptor ligand down-regulates cytosolic phospholipase A2 expression to reduce bile acid-induced cyclooxygenase 2 activity in cholangiocytes: implications of anticarcinogenic action of farnesoid X receptor agonists. Dig Dis Sci, 2005; 50: 514-24.

  • Sugiyama S. Kishida S. Chayama K. Koyama S, and Kikuchi A, Ubiquitin-interacting motifs of Epsin are involved in the regulation of insulin-dependent endocytosis. J Biochem, 2005; 137: 355-64.

  • Noguchi C. Ishino H. Tsuge M. Fujimoto Y. Imamura M. Takahashi S, and Chayama K, G to A hypermutation of hepatitis B virus. Hepatology, 2005; 41: 626-33.

  • Ueno Y. Tanaka S. Shimamoto M. Miyanaka Y. Hiyama T. Ito M. Kitadai Y. Yoshihara M. Sumii M, and Chayama K, Infliximab therapy for Crohn's disease in a patient with chronic hepatitis B. Dig Dis Sci, 2005; 50: 163-6.

  • Kamada T. Hata J. Kusunoki H. Ito M. Tanaka S. Kawamura Y. Chayama K, and Haruma K, Eradication of Helicobacter pylori increases the incidence of hyperlipidaemia and obesity in peptic ulcer patients. Dig Liver Dis, 2005; 37: 39-43.

  • Ueno Y. Tanaka S. Sumii M. Miyake S. Tazuma S. Taniguchi M. Yamamura T, and Chayama K, Single dose of OCH improves mucosal T helper type 1/T helper type 2 cytokine balance and prevents experimental colitis in the presence of valpha14 natural killer T cells in mice. Inflamm Bowel Dis, 2005; 11: 35-41.

  • Tsuji K. Naoki K. Tachiyama Y. Fukumoto A. Ishida Y. Kuwabara T. Sumida T. Tatsugami M. Nagata S. Ohgoshi H. Uraki S. Hidaka T. Akagi Y. Ishine M. Saeki S, and Chayama K, A case of congenital absence of the portal vein. Hepatol Res, 2005; 31: 43-47.

  • Imamura M. Ogawa T. Sasaguri Y. Chayama K, and Ueno H, Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats. Gastroenterology, 2005; 128: 138-46.

  • Tanaka Y. Hanada K. Orito E. Akahane Y. Chayama K. Yoshizawa H. Sata M. Ohta N. Miyakawa Y. Gojobori T, and Mizokami M, Molecular evolutionary analyses implicate injection treatment for schistosomiasis in the initial hepatitis C epidemics in Japan. J Hepatol, 2005; 42: 47-53.

  • Sanada H. Higashi Y. Goto C. Chayama K. Yoshizumi M, and Sueda T, Vascular function in patients with lower extremity peripheral arterial disease: a comparison of functions in upper and lower extremities. Atherosclerosis, 2005; 178: 179-85.

  • Matsumura S. Oue N. Nakayama H. Kitadai Y. Yoshida K. Yamaguchi Y. Imai K. Nakachi K. Matsusaki K. Chayama K, and Yasui W, A single nucleotide polymorphism in the MMP-9 promoter affects tumor progression and invasive phenotype of gastric cancer. J Cancer Res Clin Oncol, 2005; 131: 19-25.

  • Nishioka T. Hyogo H. Numata Y. Yamaguchi A. Kobuke T. Komichi D. Nonaka M. Inoue M. Nabeshima Y. Ogi M. Iwamoto K. Ishitobi T. Ajima T. Chayama K, and Tazuma S, A nuclear receptor-mediated choleretic action of fibrates is associated with enhanced canalicular membrane fluidity and transporter activity mediating bile acid-independent bile secretion. J Atheroscler Thromb, 2005; 12: 211-7.

  • Shima H. Hiyama T. Tanaka S. Ito M. Kitadai Y. Yoshihara M. Arihiro K, and Chayama K, Loss of heterozygosity on chromosome 10p14-p15 in colorectal carcinoma. Pathobiology, 2005; 72: 220-4.

  • Kimura S. Kitadai Y. Kuwai T. Tanaka S. Hihara J. Yoshida K. Toge T, and Chayama K, Expression of p53 protein in esophageal squamous cell carcinoma: relation to hypoxia-inducible factor-1alpha, angiogenesis and apoptosis. Pathobiology, 2005; 72: 179-85.

  • Okanobu H. Hata J. Haruma K. Mitsuoka Y. Kunihiro K. Manabe N. Tanaka S, and Chayama K, A classification system of echogenicity for gastrointestinal neoplasms. Digestion, 2005; 72: 8-12.

  • Naito Y. Ito M. Watanabe T. Suzuki H., Biomarkers in Patients with Gastric Inflammation: A Systematic Review. Digestion, 2005; 72: 164-180.

  • S. Oka S T, S. Nagata, M. Ito, Y. Kitadai, F. Shimamoto, M. Yoshihara, K.Chayama., Relationship between histopathological features and type V pit pattern determined by magnifying videocolonoscopy in early colorectal carcinoma. Dig Endosc, 2005; 17: 117-122.

  • S. Tanaka S O, I. Kaneko, M. Yoshihara, K.Chayama, SUPERFICIAL TYPE SERRATED ADENOMA IN ULCERATIVE COLITIS RESECTED BY ENDOSCOPIC SUBMUCOSAL DISSECTION. Dig Endosc, 2005; 17: S49-S52.

  • Ito M K S, Tanaka S, Chayama K, Yoshihara M, Haruma K., Corrrespondence. Dig Liver Dis, 2005; 37: 982.

  • Wataru Yasui N O, Yasuhiko Kitadai,Hirofumi Nakayama Recent Advances in Molecular Pathobiology of Gastric Carcinoma. The Diversity of Gastric Carcinoma, 2005 51-71

  • Y. Nakano H O, M. Miyoshi, N.Oda, Y. Hirai, T. Okimoto, K. Ishibashi, M. Yoshizumi, M. Kato, K. Dote, Chayama K., Ablation of Ventricular Tachycardia Originating from the Right Ventricle Associated with Scleroderma Cardiomyopathy. Journal of Arrhythmia. , 2005; 21: 542-545.

  • Fujiwara S N W, Suzuki G, Cologne.J.B, Akahoshi M, Hakoda M, Chayama K., A nested Case-control study of hepatocellular carcinoma among atomic-bomb survivors using stored sera. RERF Research Protocol. , 2005 1-4.