広島大学大学院医歯薬保健学研究科

消化器⋅代謝内科学

(広島大学病院 旧第一内科)

業績・活動

主要業績

主要業績

  • Yano Y. Ozono R. Oishi Y. Kambe M. Yoshizumi M. Ishida T. Omura S. Oshima T, and Igarashi K, Genetic ablation of the transcription repressor Bach1 leads to myocardial protection against ischemia/reperfusion in mice. Genes Cells, 2006; 11: 791-803.

  • Hamamoto R. Silva F P. Tsuge M. Nishidate T. Katagiri T. Nakamura Y, and Furukawa Y, Enhanced SMYD3 expression is essential for the growth of breast cancer cells. Cancer Sci, 2006; 97: 113-8.

  • Yoshino T. Nakamura S. Matsuno Y. Ochiai A. Yokoi T. Kitadai Y. Suzumiya J. Tobinai K. Kobayashi Y. Oda I. Mera K. Ohtsu A, and Ishikura S, Epstein-Barr virus involvement is a predictive factor for the resistance to chemoradiotherapy of gastric diffuse large B-cell lymphoma. Cancer Sci, 2006; 97: 163-6.

  • Kitadai Y. Sasaki T. Kuwai T. Nakamura T. Bucana C D. Hamilton S R, and Fidler I J, Expression of activated platelet-derived growth factor receptor in stromal cells of human colon carcinomas is associated with metastatic potential. Int J Cancer, 2006; 119: 2567-74.

  • Kitadai Y. Sasaki T. Kuwai T. Nakamura T. Bucana C D, and Fidler I J, Targeting the expression of platelet-derived growth factor receptor by reactive stroma inhibits growth and metastasis of human colon carcinoma. Am J Pathol, 2006; 169: 2054-65.

  • Yang L. Avila H. Wang H. Trevino J. Gallick G E. Kitadai Y. Sasaki T, and Boyd D D, Plasticity in urokinase-type plasminogen activator receptor (uPAR) display in colon cancer yields metastable subpopulations oscillating in cell surface uPAR density--implications in tumor progression. Cancer Res, 2006; 66: 7957-67.

  • Hiyama T. Yoshihara M. Tanaka S. Urabe Y. Ikegami Y. Fukuhara T, and Chayama K, Defensive medicine practices among gastroenterologists in Japan. World J Gastroenterol, 2006; 12: 7671-5.

  • Umemura T. Ueda K. Nishioka K. Hidaka T. Takemoto H. Nakamura S. Jitsuiki D. Soga J. Goto C. Chayama K. Yoshizumi M, and Higashi Y, Effects of acute administration of caffeine on vascular function. Am J Cardiol, 2006; 98: 1538-41.

  • Oka S. Tanaka S. Kaneko I. Mouri R. Hirata M. Kawamura T. Yoshihara M, and Chayama K, Advantage of endoscopic submucosal dissection compared with EMR for early gastric cancer. Gastrointest Endosc, 2006; 64: 877-83.

  • Matsumoto Y. Manabe N. Tanaka S. Fukumoto A. Yamaguchi T. Shimamoto M. Nakao M. Mitsuoka Y, and Chayama K, Small-intestinal Peutz-Jeghers polyps resected by endoscopic polypectomy with double-balloon enteroscopy and removal confirmed by ultrasonography. Dig Dis Sci, 2006; 51: 2337-40.

  • Cho S. Kitadai Y. Yoshida S. Tanaka S. Yoshihara M. Yoshida K, and Chayama K, Genetic and pathologic characteristics of gastrointestinal stromal tumors in extragastric lesions. Int J Mol Med, 2006; 18: 1067-71.

  • Ohishi W. Fujiwara S. Suzuki G. Kishi T. Sora M. Matsuura S. Hakoda M. Tatsukawa Y. Yamada M, and Chayama K, Feasibility of freeze-dried sera for serological and molecular biological detection of hepatitis B and C viruses. J Clin Microbiol, 2006; 44: 4593-5.

  • Hiyama T. Tanaka S. Yoshihara M. Fukuhara T. Mukai S, and Chayama K, Medical malpractice litigation related to gastrointestinal endoscopy in Japan: a two-decade review of civil court cases. World J Gastroenterol, 2006; 12: 6857-60.

  • Yatsuji H. Noguchi C. Hiraga N. Mori N. Tsuge M. Imamura M. Takahashi S. Iwao E. Fujimoto Y. Ochi H. Abe H. Maekawa T. Tateno C. Yoshizato K. Suzuki F. Kumada H, and Chayama K, Emergence of a novel lamivudine-resistant hepatitis B virus variant with a substitution outside the YMDD motif. Antimicrob Agents Chemother, 2006; 50: 3867-74.

  • Oka S. Tanaka S. Kaneko I. Mouri R. Hirata M. Kanao H. Kawamura T. Yoshida S. Yoshihara M, and Chayama K, Endoscopic submucosal dissection for residual/local recurrence of early gastric cancer after endoscopic mucosal resection. Endoscopy, 2006; 38: 996-1000.

  • Serikawa M. Sasaki T. Fujimoto Y. Kuwahara K, and Chayama K, Management of intraductal papillary-mucinous neoplasm of the pancreas: treatment strategy based on morphologic classification. J Clin Gastroenterol, 2006; 40: 856-62.

  • Umemura T. Nishioka K. Igarashi A. Kato Y. Ochi M. Chayama K. Yoshizumi M, and Higashi Y, Autologous bone marrow mononuclear cell implantation induces angiogenesis and bone regeneration in a patient with compartment syndrome. Circ J, 2006; 70: 1362-4.

  • Tanaka S. Kaltenbach T. Chayama K, and Soetikno R, High-magnification colonoscopy (with videos). Gastrointest Endosc, 2006; 64: 604-13.

  • Shima H. Hiyama T. Tanaka S. Yoshihara M. Arihiro K, and Chayama K, Genetic progression and divergence in superficial esophageal squamous cell carcinoma by loss of heterozygosity analysis. Oncol Rep, 2006; 16: 685-91.

  • Sasao S. Hiyama T. Tanaka S. Mukai S. Yoshihara M, and Chayama K, Medical malpractice litigation in gastroenterological practice in Japan: a 22-yr review of civil court cases. Am J Gastroenterol, 2006; 101: 1951-3.

  • Kobuke T. Tazuma S. Hyogo H, and Chayama K, A Ligand for peroxisome proliferator-activated receptor gamma inhibits human cholangiocarcinoma cell growth: potential molecular targeting strategy for cholangioma. Dig Dis Sci, 2006; 51: 1650-7.

  • Ueno Y. Tanaka S. Kanao H. Yoshioka K. Hatakeyama T. Shimamoto M. Miyanaka Y. Hiyama T. Ito M. Kitadai Y. Yoshihara M, and Chayama K, A case of Crohn's disease with hydronephrosis caused by ureteropelvic junction obstruction. Eur J Gastroenterol Hepatol, 2006; 18: 1015-8.

  • Egi Y. Kim S. Ito M. Tanaka S. Yoshihara M. Haruma K, and Chayama K, Helicobacter pylori infection is the major risk factor for gastric inflammation in the cardia. Dig Dis Sci, 2006; 51: 1582-8.

  • Nabeshima Y. Tazuma S. Kanno K. Hyogo H. Iwai M. Horiuchi M, and Chayama K, Anti-fibrogenic function of angiotensin II type 2 receptor in CCl4-induced liver fibrosis. Biochem Biophys Res Commun, 2006; 346: 658-64.

  • Umehara T. Sudoh M. Yasui F. Matsuda C. Hayashi Y. Chayama K, and Kohara M, Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse model. Biochem Biophys Res Commun, 2006; 346: 67-73.

  • Kunihiro K. Manabe N. Hata J. Kamino D. Nakao M. Mitsuoka Y. Tanaka S, and Chayama K, Gastrointestinal stromal tumor in jejunum: diagnosis using contrast-enhanced ultrasonography and double-balloon enteroscopy. Dig Dis Sci, 2006; 51: 1236-40.

  • Manabe N. Tanaka S. Fukumoto A. Nakao M. Kamino D, and Chayama K, Double-balloon enteroscopy in patients with GI bleeding of obscure origin. Gastrointest Endosc, 2006; 64: 135-40.

  • Sasao S. Hiyama T. Tanaka S. Yoshihara M. Yasui W, and Chayama K, Clinicopathologic and genetic characteristics of gastric cancer in young male and female patients. Oncol Rep, 2006; 16: 11-5.

  • Kamino D. Hata J. Haruma K. Manabe N. Tanaka S, and Chayama K, Real-time visualization and quantitation of canine gastric mucosal blood flow by contrast-enhanced ultrasonography. Scand J Gastroenterol, 2006; 41: 856-61.

  • Ochiumi T. Kitadai Y. Tanaka S. Akagi M. Yoshihara M, and Chayama K, Neuropilin-1 is involved in regulation of apoptosis and migration of human colon cancer. Int J Oncol, 2006; 29: 105-16.

  • Yokomichi H. Tsuji K. Hayashi Y. Kaneko M. Nakadoi K. Ishida Y. Kuwabara T. Tsumuna T. Sumida T. Nagata S. Ohgoshi H. Uraki S. Hidaka T, and Chayama K, A case of multiple hepatic peribiliary cysts which contributed to the obstructive jaundice and led to liver failure at the young man with von Recklinghausen's disease. Hepatol Res, 2006; 35: 222-7.

  • Cho S. Kitadai Y. Yoshida S. Tanaka S. Yoshihara M. Yoshida K, and Chayama K, Deletion of the KIT gene is associated with liver metastasis and poor prognosis in patients with gastrointestinal stromal tumor in the stomach. Int J Oncol, 2006; 28: 1361-7.

  • Higashi Y. Sasaki S. Nakagawa K. Kimura M. Noma K. Hara K. Jitsuiki D. Goto C. Oshima T. Chayama K, and Yoshizumi M, Tetrahydrobiopterin improves aging-related impairment of endothelium-dependent vasodilation through increase in nitric oxide production. Atherosclerosis, 2006; 186: 390-5.

  • Kim S. Ito M. Haruma K. Egi Y. Ueda H. Tanaka S, and Chayama K, Surface structure of antral gastric mucosa represents the status of histologic gastritis: fundamental evidence for the evaluation of antral gastritis by magnifying endoscopy. J Gastroenterol Hepatol, 2006; 21: 837-41.

  • Yamaguchi T. Manabe N. Hata J. Tanaka S. Haruma K, and Chayama K, The usefulness of transabdominal ultrasound for the diagnosis of lower gastrointestinal bleeding. Aliment Pharmacol Ther, 2006; 23: 1267-72.

  • Higashi Y. Nishioka K. Umemura T. Chayama K, and Yoshizumi M, Oxidative stress, endothelial function and angiogenesis induced by cell therapy and gene therapy. Curr Pharm Biotechnol, 2006; 7: 109-16.

  • Ueda H. Ito M. Tanaka S. Oka S. Takata S. Imagawa S. Xie X F. Yoshihara M. Haruma K, and Chayama K, The effect of Helicobacter pylori eradication therapy on gastric ulcer healing after endoscopic mucosal resection. J Clin Gastroenterol, 2006; 40: 293-6.

  • Miyata H. Sasaki T. Kuwahara K. Serikawa M, and Chayama K, The effects of ZD1839 (Iressa), a highly selective EGFR tyrosine kinase inhibitor, as a radiosensitiser in bile duct carcinoma cell lines. Int J Oncol, 2006; 28: 915-21.

  • Tanaka S. Haruma K. Yoshihara M. Kajiyama G. Kira K. Amagase H, and Chayama K, Aged garlic extract has potential suppressive effect on colorectal adenomas in humans. J Nutr, 2006; 136: 821S-826S.

  • Soetikno R. Friedland S. Kaltenbach T. Chayama K, and Tanaka S, Nonpolypoid (flat and depressed) colorectal neoplasms. Gastroenterology, 2006; 130: 566-76; quiz 588-9.

  • Yamashina K. Yamamoto H. Chayama K. Nakajima K, and Kikuchi A, Suppression of STAT3 activity by Duplin, which is a negative regulator of the Wnt signal. J Biochem, 2006; 139: 305-14.

  • Tanaka E. Matsumoto A. Suzuki F. Kobayashi M. Mizokami M. Tanaka Y. Okanoue T. Minami M. Chayama K. Imamura M. Yatsuhashi H. Nagaoka S. Yotsuyanagi H. Kawata S. Kimura T. Maki N. Iino S. Kiyosawa K, and Group H B V C-R A S, Measurement of hepatitis B virus core-related antigen is valuable for identifying patients who are at low risk of lamivudine resistance. Liver International, 2006; 26: 90-6.

  • Ito M. Tanaka S. Kamada T. Haruma K, and Chayama K, Causal role of Helicobacter pylori infection and eradication therapy in gastric carcinogenesis. World J Gastroenterol, 2006; 12: 10-6.

  • Kamada T. Sugiu K. Hata J. Kusunoki H. Hamada H. Kido S. Nagashima Y. Kawamura Y. Tanaka S. Chayama K, and Haruma K, Evaluation of endoscopic and histological findings in Helicobacter pylori-positive Japanese young adults. J Gastroenterol Hepatol, 2006; 21: 258-61.

  • Higashi Y. Jitsuiki D. Chayama K, and Yoshizumi M, Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, for treatment of cardiovascular diseases. Recent Pat Cardiovasc Drug Discov, 2006; 1: 85-93.

  • Kose K. Hiyama T. Tanaka S. Yoshihara M. Yasui W, and Chayama K, Nuclear and mitochondrial DNA microsatellite instability in gastrointestinal stromal tumors. Pathobiology, 2006; 73: 93-7.

  • Ueda H. Ito M. Eguchi H. Tanaka S. Yoshihara M. Haruma K. Hatakeyama M, and Chayama K, Development of a novel method to detect Helicobacter pylori cagA genotype from paraffin-embedded materials: comparison between patients with duodenal ulcer and gastric cancer in young Japanese. Digestion, 2006; 73: 47-53.

  • Ni L. Teragawa H. Ueda K. Takemoto H. Hidaka T. Nishioka K. Soga J. Oda N. Nakano Y. Shingu T, and Chayama K, Successive, rapid recurrences of in-stent restenoses in a woman with angina pectoris. Intern Med, 2006; 45: 1093-6.

  • Kohno H. Aimitsu S. Kitamoto M. Aisaka Y. Kawakami H, and Chayama K, Prolonged negative HCV-RNA status led to a good outcome in chronic hepatitis C patients with genotype 1b and super-high viral load. Intervirology, 2006; 49: 362-9.

  • Arataki K. Kumada H. Toyota K. Ohishi W. Takahashi S. Tazuma S, and Chayama K, Evolution of hepatitis C virus quasispecies during ribavirin and interferon-alpha-2b combination therapy and interferon-alpha-2b monotherapy. Intervirology, 2006; 49: 352-61.

  • Tomohiro Kawahara S T, Makoto Kaneko., Non-Contact Stiffness Imager. The International Journal of Robotics Research, 2006; 25: 537-549

  • Shinji Tanaka S O, Mayuko Hirata, Shigeto Yoshida, Iwao Kaneko, Kazuaki Chayama, PIT PATTERN DIAGNOSIS FOR COLORECTAL NEOPLASIA USING NARROW BAND IMAGING MAGNIFICATION. Digestive Endoscopy, 2006; 18: S52-S54.

  • S. Takenaka Y N, H. Hirao, H. Teragawa, T. Shingu, Chayama K., Coronary Sinus Morphology in Patients with Posteroseptal Atrioventricular Accessory Pathways. Journal of Arrhythmia. , 2006; 22: 149-154.

  • H.Ogi Y N, N.Oda, M. Miyoshi, Chayama K, K. Ishibashi, Y. Hirai, T. Okimoto., Ablation of Idiopathic Ventricular Tachycardia with a Left Bundle-Branch Block Morphology Originating from the Pulmonary Artery. J Arrthmia. , 2006; 22: 180-186.

  • Lima DCA T S, Arantes VN, Taranto MPL, Treatment Endoscopic das Neoplasias Superficies do Trato Digestive. Guanabara Koogan S.A , Rio de Janeiro, RJ-Brazil, 2006 82-99.