広島大学大学院医歯薬保健学研究科

消化器⋅代謝内科学

(広島大学病院 旧第一内科)

業績・活動

主要業績

主要業績

  • Ohmiya N. Yano T. Yamamoto H. Arakawa D. Nakamura M. Honda W. Itoh A. Hirooka Y. Niwa Y. Maeda O. Ando T. Yao T. Matsui T. Iida M. Tanaka S. Chiba T. Sakamoto C. Sugano K, and Goto H, Diagnosis and treatment of obscure GI bleeding at double balloon endoscopy. Gastrointest Endosc, 2007; 66: S72-7.

  • Fukumoto A. Tanaka S. Yamamoto H. Yao T. Matsui T. Iida M. Goto H. Sakamoto C. Chiba T, and Sugano K, Diagnosis and treatment of small-bowel stricture by double balloon endoscopy. Gastrointest Endosc, 2007; 66: S108-12.

  • Kawaoka T. Suzuki F. Akuta N. Suzuki Y. Arase Y. Sezaki H. Kawamura Y. Hosaka T. Kobayashi M. Ikeda K, and Kumada H, Efficacy of lamivudine therapy in elderly patients with chronic hepatitis B infection. J Gastroenterol, 2007; 42: 395-401.

  • Mitani Y. Oue N. Matsumura S. Yoshida K. Noguchi T. Ito M. Tanaka S. Kuniyasu H. Kamata N, and Yasui W, Reg IV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy. Oncogene, 2007; 26: 4383-93.

  • Yoshihara M. Hiyama T. Yoshida S. Ito M. Tanaka S. Watanabe Y, and Haruma K, Reduction in gastric cancer mortality by screening based on serum pepsinogen concentration: a case-control study. Scand J Gastroenterol, 2007; 42: 760-4.

  • Miwa H. Sasaki M. Furuta T. Koike T. Habu Y. Ito M. Fujiwara Y. Wada T. Nagahara A. Hongo M. Chiba T, and Kinoshita Y, Efficacy of rabeprazole on heartburn symptom resolution in patients with non-erosive and erosive gastro-oesophageal reflux disease: a multicenter study from Japan. Aliment Pharmacol Ther, 2007; 26: 69-77.

  • Sasaki T. Kitadai Y. Nakamura T. Kim J S. Tsan R Z. Kuwai T. Langley R R. Fan D. Kim S J, and Fidler I J, Inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation on tumor-associated endothelial cells leads to treatment of orthotopic human colon cancer in nude mice. Neoplasia, 2007; 9: 1066-77.

  • Nakamura T. Kuwai T. Kitadai Y. Sasaki T. Fan D. Coombes K R. Kim S J, and Fidler I J, Zonal heterogeneity for gene expression in human pancreatic carcinoma. Cancer Res, 2007; 67: 7597-604.

  • Shimamoto M. Ueno Y. Tanaka S. Onitake T. Hanaoka R. Yoshioka K. Hatakeyama T, and Chayama K, Selective decrease in colonic CD56(+) T and CD161(+) T cells in the inflamed mucosa of patients with ulcerative colitis. World J Gastroenterol, 2007; 13: 5995-6002.

  • Tokimitsu Y. Kishi H. Kondo S. Honda R. Tajiri K. Motoki K. Ozawa T. Kadowaki S. Obata T. Fujiki S. Tateno C. Takaishi H. Chayama K. Yoshizato K. Tamiya E. Sugiyama T, and Muraguchi A, Single lymphocyte analysis with a microwell array chip. Cytometry A, 2007; 71: 1003-10.

  • Yatsuji H. Hiraga N. Mori N. Hatakeyama T. Tsuge M. Imamura M. Takahashi S. Fujimoto Y. Ochi H. Abe H. Maekawa T. Suzuki F. Kumada H, and Chayama K, Successful treatment of an entecavir-resistant hepatitis B virus variant. J Med Virol, 2007; 79: 1811-7.

  • Fujii Y. Nishioka K. Yoshizumi M. Chayama K, and Higashi Y, Images in cardiovascular medicine. Corkscrew collaterals in thromboangitis obliterans (Buerger's disease). Circulation, 2007; 116: e539-40.

  • Hirata M. Tanaka S. Oka S. Kaneko I. Yoshida S. Yoshihara M, and Chayama K, Evaluation of microvessels in colorectal tumors by narrow band imaging magnification. Gastrointest Endosc, 2007; 66: 945-52.

  • Tashiro H. Itamoto T. Sasaki T. Ohdan H. Fudaba Y. Amano H. Fukuda S. Nakahara H. Ishiyama K. Ohshita A. Kohashi T. Mitsuta H. Chayama K, and Asahara T, Biliary complications after duct-to-duct biliary reconstruction in living-donor liver transplantation: causes and treatment. World J Surg, 2007; 31: 2222-9.

  • Uka K. Aikata H. Takaki S. Miki D. Jeong S C. Hiramatsu A. Kodama H. Shirakawa H. Kawakami Y. Takahashi S. Toyota N. Ito K, and Chayama K, Similar effects of recombinant interferon-alpha-2b and natural interferon-alpha when combined with intra-arterial 5-fluorouracil for the treatment of advanced hepatocellular carcinoma. Liver International, 2007; 27: 1209-16.

  • Jeong S C. Aikata H. Katamura Y. Azakami T. Kawaoka T. Saneto H. Uka K. Mori N. Takaki S. Kodama H. Waki K. Imamura M. Shirakawa H. Kawakami Y. Takahashi S, and Chayama K, Effects of a 24-week course of interferon-alpha therapy after curative treatment of hepatitis C virus-associated hepatocellular carcinoma. World J Gastroenterol, 2007; 13: 5343-50.

  • Jeong S. Aikata H. Katamura Y. Azakami T. Kawaoka T. Saneto H. Uka K. Mori N. Takaki S. Kodama H. Waki K. Imamura M. Shirakawa H. Kawakami Y. Takahashi S, and Chayama K, Low-dose intermittent interferon-alpha therapy for HCV-related liver cirrhosis after curative treatment of hepatocellular carcinoma. World J Gastroenterol, 2007; 13: 5188-95.

  • Hiyama T. Yoshihara M. Tanaka S, and Chayama K, Genetic polymorphisms and esophageal cancer risk. Int J Cancer, 2007; 121: 1643-58.

  • Hiyama T. Yoshihara M. Matsuo K. Kusunoki H. Kamada T. Ito M. Tanaka S. Chayama K, and Haruma K, Treatment of functional dyspepsia with serotonin agonists: a meta-analysis of randomized controlled trials. J Gastroenterol Hepatol, 2007; 22: 1566-70.

  • Uka K. Aikata H. Takaki S. Miki D. Kawaoka T. Jeong S C. Takahashi S. Toyota N. Ito K, and Chayama K, Pretreatment predictor of response, time to progression, and survival to intraarterial 5-fluorouracil/interferon combination therapy in patients with advanced hepatocellular carcinoma. J Gastroenterol, 2007; 42: 845-53.

  • Nishioka K. Hidaka T. Nakamura S. Umemura T. Jitsuiki D. Soga J. Goto C. Chayama K. Yoshizumi M, and Higashi Y, Pycnogenol, French maritime pine bark extract, augments endothelium-dependent vasodilation in humans. Hypertension Research, 2007; 30: 775-80.

  • Xie X F. Ito M. Yoshihara M. Haruma K. Tanaka S, and Chayama K, Serum pepsinogen levels in the Japanese population: prospective study of 9 years of follow-up. Hepatogastroenterology, 2007; 54: 1887-90.

  • Mukai S. Hiyama T. Tanaka S. Yoshihara M. Arihiro K, and Chayama K, Involvement of Kruppel-like factor 6 (KLF6) mutation in the development of nonpolypoid colorectal carcinoma. World J Gastroenterol, 2007; 13: 3932-8.

  • Hiraga N. Aikata H. Takaki S. Kodama H. Shirakawa H. Imamura M. Kawakami Y. Takahashi S. Toyota N. Ito K. Tanaka S. Kitamoto M, and Chayama K, The long-term outcome of patients with bleeding gastric varices after balloon-occluded retrograde transvenous obliteration. J Gastroenterol, 2007; 42: 663-72.

  • Goto C. Nishioka K. Umemura T. Jitsuiki D. Sakagutchi A. Kawamura M. Chayama K. Yoshizumi M, and Higashi Y, Acute moderate-intensity exercise induces vasodilation through an increase in nitric oxide bioavailiability in humans. Am J Hypertens, 2007; 20: 825-30.

  • Matsumoto A. Tanaka E. Minami M. Okanoue T. Yatsuhashi H. Nagaoka S. Suzuki F. Kobayashi M. Chayama K. Imamura M. Yotsuyanagi H. Nakaoka S. Maki N. Kawata S. Kumada H. Iino S, and Kiyosawa K, Low serum level of hepatitis B core-related antigen indicates unlikely reactivation of hepatitis after cessation of lamivudine therapy. Hepatol Res, 2007; 37: 661-6.

  • Kaneko I. Tanaka S. Oka S. Yoshida S. Hiyama T. Arihiro K. Shimamoto F, and Chayama K, Immunohistochemical molecular markers as predictors of curability of endoscopically resected submucosal colorectal cancer. World J Gastroenterol, 2007; 13: 3829-35.

  • Yoshida S. Tanaka S. Hirata M. Mouri R. Kaneko I. Oka S. Yoshihara M, and Chayama K, Optical biopsy of GI lesions by reflectance-type laser-scanning confocal microscopy. Gastrointest Endosc, 2007; 66: 144-9.

  • Tanaka S. Oka S. Kaneko I. Hirata M. Mouri R. Kanao H. Yoshida S, and Chayama K, Endoscopic submucosal dissection for colorectal neoplasia: possibility of standardization. Gastrointest Endosc, 2007; 66: 100-7.

  • Hyogo H. Yamagishi S. Iwamoto K. Arihiro K. Takeuchi M. Sato T. Ochi H. Nonaka M. Nabeshima Y. Inoue M. Ishitobi T. Chayama K, and Tazuma S, Elevated levels of serum advanced glycation end products in patients with non-alcoholic steatohepatitis. J Gastroenterol Hepatol, 2007; 22: 1112-9.

  • Miyanaka Y. Ueno Y. Tanaka S. Yoshioka K. Hatakeyama T. Shimamoto M. Sumii M, and Chayama K, Clinical significance of mucosal suppressors of cytokine signaling 3 expression in ulcerative colitis. World J Gastroenterol, 2007; 13: 2939-44.

  • Kusunoki H. Hata J. Aoki S. Kamada T. Ishii M. Sato M. Tanaka T. Manabe N. Shiotani A. Yoshida S. Tanaka S. Chayama K, and Haruma K, Stepped assessment of gastric emptying of a solid meal using the (13)C-octanoic acid breath test. J Smooth Muscle Res, 2007; 43: 99-107.

  • Tashiro H. Itamoto T. Ohdan H. Fudaba Y. Kohashi T. Amano H. Ishiyama K. Takahashi S. Aikata H. Chayama K. Arihiro K, and Asahara T, Should splenectomy be performed for hepatitis C patients undergoing living-donor liver transplantation? J Gastroenterol Hepatol, 2007; 22: 959-60.

  • Kimura M. Ueda K. Goto C. Jitsuiki D. Nishioka K. Umemura T. Noma K. Yoshizumi M. Chayama K, and Higashi Y, Repetition of ischemic preconditioning augments endothelium-dependent vasodilation in humans: role of endothelium-derived nitric oxide and endothelial progenitor cells. Arterioscler Thromb Vasc Biol, 2007; 27: 1403-10.

  • Hirata M. Tanaka S. Oka S. Kaneko I. Yoshida S. Yoshihara M, and Chayama K, Magnifying endoscopy with narrow band imaging for diagnosis of colorectal tumors. Gastrointest Endosc, 2007; 65: 988-95.

  • Chen H. Takahashi S. Imamura M. Okutani E. Zhang Z G. Chayama K, and Chen B A, Earthworm fibrinolytic enzyme: anti-tumor activity on human hepatoma cells in vitro and in vivo. Chin Med J (Engl) , 2007; 120: 898-904.

  • Hiraga N. Imamura M. Tsuge M. Noguchi C. Takahashi S. Iwao E. Fujimoto Y. Abe H. Maekawa T. Ochi H. Tateno C. Yoshizato K. Sakai A. Sakai Y. Honda M. Kaneko S. Wakita T, and Chayama K, Infection of human hepatocyte chimeric mouse with genetically engineered hepatitis C virus and its susceptibility to interferon. FEBS Lett, 2007; 581: 1983-7.

  • Egi Y. Ito M. Tanaka S. Imagawa S. Takata S. Yoshihara M. Haruma K, and Chayama K, Role of Helicobacter pylori infection and chronic inflammation in gastric cancer in the cardia. Jpn J Clin Oncol, 2007; 37: 365-9.

  • Soga J. Nishioka K. Nakamura S. Umemura T. Jitsuiki D. Hidaka T. Teragawa H. Takemoto H. Goto C. Yoshizumi M. Chayama K, and Higashi Y, Measurement of flow-mediated vasodilation of the brachial artery: a comparison of measurements in the seated and supine positions. Circ J, 2007; 71: 736-40.

  • Kunihiro K. Hata J. Manabe N. Mitsuoka Y. Tanaka S. Haruma K, and Chayama K, Predicting the need for surgery in Crohn's disease with contrast harmonic ultrasound. Scand J Gastroenterol, 2007; 42: 577-85.

  • Hatakeyama T. Noguchi C. Hiraga N. Mori N. Tsuge M. Imamura M. Takahashi S. Kawakami Y. Fujimoto Y. Ochi H. Abe H. Maekawa T. Kawakami H. Yatsuji H. Aisaka Y. Kohno H. Aimitsu S, and Chayama K, Serum HBV RNA is a predictor of early emergence of the YMDD mutant in patients treated with lamivudine. Hepatology, 2007; 45: 1179-86.

  • Brydun A. Watari Y. Yamamoto Y. Okuhara K. Teragawa H. Kono F. Chayama K. Oshima T, and Ozono R, Reduced expression of heme oxygenase-1 in patients with coronary atherosclerosis. Hypertension Research, 2007; 30: 341-8.

  • Mitsuoka Y. Hata J. Haruma K. Manabe N. Tanaka S, and Chayama K, New method of evaluating gastric mucosal blood flow by ultrasound. Scand J Gastroenterol, 2007; 42: 513-8.

  • Miyazaki M. Higashi Y. Goto C. Chayama K. Yoshizumi M. Sanada H. Orihashi K, and Sueda T, Sarpogrelate hydrochloride, a selective 5-HT2A antagonist, improves vascular function in patients with peripheral arterial disease. J Cardiovasc Pharmacol, 2007; 49: 221-7.

  • Takata S. Ito M. Yoshihara M. Tanaka S. Imagawa S. Haruma K, and Chayama K, Host factors contributing to the discovery of gastric cancer after successful eradication therapy of Helicobacter pylori: preliminary report. J Gastroenterol Hepatol, 2007; 22: 571-6.

  • Fukumoto A. Manabe N. Tanaka S. Yamaguchi T. Matsumoto Y, and Chayama K, Usefulness of EUS with double-balloon enteroscopy for diagnosis of small-bowel diseases. Gastrointest Endosc, 2007; 65: 412-20.

  • Hiyama T. Yoshihara M. Matsuo K. Kusunoki H. Kamada T. Ito M. Tanaka S. Nishi N. Chayama K, and Haruma K, Meta-analysis of the effects of prokinetic agents in patients with functional dyspepsia. J Gastroenterol Hepatol, 2007; 22: 304-10.

  • Noma K. Goto C. Nishioka K. Jitsuiki D. Umemura T. Ueda K. Kimura M. Nakagawa K. Oshima T. Chayama K. Yoshizumi M. Liao J K, and Higashi Y, Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness. J Am Coll Cardiol, 2007; 49: 698-705.

  • Kimura S. Tanaka S. Kusunoki H. Kitadai Y. Sumii M. Tazuma S. Yoshihara M. Haruma K, and Chayama K, Cavernous hemangioma in the ascending colon treated by endoscopic mucosal resection. J Gastroenterol Hepatol, 2007; 22: 280-1.

  • Noguchi C. Hiraga N. Mori N. Tsuge M. Imamura M. Takahashi S. Fujimoto Y. Ochi H. Abe H. Maekawa T. Yatsuji H. Shirakawa K. Takaori-Kondo A, and Chayama K, Dual effect of APOBEC3G on Hepatitis B virus. J Gen Virol, 2007; 88: 432-40.

  • Kodama M. Kitadai Y. Ito M. Kai H. Masuda H. Tanaka S. Yoshihara M. Fujimura K, and Chayama K, Immune response to CagA protein is associated with improved platelet count after Helicobacter pylori eradication in patients with idiopathic thrombocytopenic purpura. Helicobacter, 2007; 12: 36-42.

  • Nishioka K. Nakagawa K. Umemura T. Jitsuiki D. Ueda K. Goto C. Chayama K. Yoshizumi M, and Higashi Y, Carvedilol improves endothelium-dependent vasodilation in patients with dilated cardiomyopathy. Heart, 2007; 93: 247-8.

  • Uka K. Aikata H. Takaki S. Shirakawa H. Jeong S C. Yamashina K. Hiramatsu A. Kodama H. Takahashi S, and Chayama K, Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma. World J Gastroenterol, 2007; 13: 414-20.

  • Miyoshi M. Nakano Y. Sakaguchi T. Ogi H. Oda N. Suenari K. Kiyotani K. Ozono R. Oshima T. Yoshida T, and Chayama K, Gene delivery of paraoxonase-1 inhibits neointimal hyperplasia after arterial balloon-injury in rabbits fed a high-fat diet. Hypertension Research, 2007; 30: 85-91.

  • Nakano Y. Tashiro S. Kinoshita E. Kinoshita-Kikuta E. Takenaka S. Miyoshi M. Ogi H. Sakoda E. Oda N. Suenari K. Tonouchi Y. Okimoto T. Hirai Y. Miura F. Yamaoka K. Koike T, and Chayama K, Non-SCN5A related Brugada syndromes: verification of normal splicing and trafficking of SCN5A without exonic mutations. Ann Hum Genet, 2007; 71: 8-17.

  • Tari A. Kitadai Y. Sumii M. Sasaki A. Tani H. Tanaka S, and Chayama K, Basis of decreased risk of gastric cancer in severe atrophic gastritis with eradication of Helicobacter pylori. Dig Dis Sci, 2007; 52: 232-9.

  • Kaneko I. Tanaka S. Oka S. Kawamura T. Hiyama T. Ito M. Yoshihara M. Shimamoto F, and Chayama K, Lymphatic vessel density at the site of deepest penetration as a predictor of lymph node metastasis in submucosal colorectal cancer. Dis Colon Rectum, 2007; 50: 13-21.

  • Xie X F. Ito M. Sumii M. Tanaka S. Yoshihara M, and Chayama K, Helicobacter pylori-associated gastritis is related to babA2 expression without heterogeneity of the 3' region of the cagA genotype in gastric biopsy specimens. Pathobiology, 2007; 74: 309-16.

  • Takaki S. Kawakami Y. Imamura M. Aikata H. Takahashi S. Ishihara H. Tsuji K. Aimitsu S. Kawakami H. Nakanishi T. Kitamoto M. Moriya T. Satoh K, and Chayama K, Eicosapentaenoic acid could permit maintenance of the original ribavirin dose in chronic hepatitis C virus patients during the first 12 weeks of combination therapy with pegylated interferon-alpha and ribavirin. A prospective randomized controlled trial. Intervirology, 2007; 50: 439-46.

  • Kodama H. Aikata H. Uka K. Takaki S. Mori N. Waki K. Jeong S C. Kawakami Y. Shirakawa H. Takahashi S. Toyota N. Ito K, and Chayama K, Efficacy of percutaneous cementoplasty for bone metastasis from hepatocellular carcinoma. Oncology, 2007; 72: 285-92.

  • Katamura Y. Aikata H. Azakami T. Kawaoka T. Uka K. Yamashina K. Takaki S. Kodama H. Cheol J S. Hiramatsu A. Imamura M. Kawakami Y. Takahashi S. Toyota N. Ito K, and Chayama K, Balloon-occluded retrograde transvenous obliteration for portal-systemic encephalopathy due to superior mesenteric-caval shunt via the right gonadal vein. Intern Med, 2007; 46: 1479-80.

  • Oue N. Kuniyasu H. Noguchi T. Sentani K. Ito M. Tanaka S. Setoyama T. Sakakura C. Natsugoe S, and Yasui W, Serum concentration of Reg IV in patients with colorectal cancer: overexpression and high serum levels of Reg IV are associated with liver metastasis. Oncology, 2007; 72: 371-80.

  • Kamada T. Tanaka A. Yamanaka Y. Manabe N. Kusunoki H. Miyamoto M. Tanaka S. Hata J. Chayama K, and Haruma K, Nodular Gastritis with Helicobacter Pylori Infection Is Strongly Associated with Diffuse-Type Gastric Cancer in Young Patients. Digestive Endoscopy, 2007; 19: 180-184.

  • Oka S. Tanaka S. Kaneko I. Kanao H, and Chayama K, Techniques and Pitfalls of Endoscopic Submucosal Dissection for Colorectal Tumors. Digestive Endoscopy, 2007; 19: S30-S33.