(広島大学病院 旧第一内科)




  • Kudo S. Lambert R. Allen J I. Fujii H. Fujii T. Kashida H. Matsuda T. Mori M. Saito H. Shimoda T. Tanaka S. Watanabe H. Sung J J. Feld A D. Inadomi J M. O'Brien M J. Lieberman D A. Ransohoff D F. Soetikno R M. Triadafilopoulos G. Zauber A. Teixeira C R. Rey J F. Jaramillo E. Rubio C A. Van Gossum A. Jung M. Vieth M. Jass J R, and Hurlstone P D, Nonpolypoid neoplastic lesions of the colorectal mucosa. Gastrointest Endosc. 2008; 68: S3-47.

  • Kuwai T. Nakamura T. Kim S J. Sasaki T. Kitadai Y. Langley R R. Fan D. Hamilton S R, and Fidler I J, Intratumoral heterogeneity for expression of tyrosine kinase growth factor receptors in human colon cancer surgical specimens and orthotopic tumors. Am J Pathol. 2008; 172: 358-66.

  • Silva F P. Hamamoto R. Kunizaki M. Tsuge M. Nakamura Y, and Furukawa Y, Enhanced methyltransferase activity of SMYD3 by the cleavage of its N-terminal region in human cancer cells. Oncogene. 2008; 27: 2686-92.

  • Noma B. Sasaki T. Fujimoto Y. Serikawa M. Kobayashi K. Inoue M. Itsuki H. Kamigaki M. Minami T, and Chayama K, Expression of multidrug resistance-associated protein 2 is involved in chemotherapy resistance in human pancreatic cancer. Int J Oncol. 2008; 33: 1187-94.

  • Hyogo H. Tazuma S. Arihiro K. Iwamoto K. Nabeshima Y. Inoue M. Ishitobi T. Nonaka M, and Chayama K, Efficacy of atorvastatin for the treatment of nonalcoholic steatohepatitis with dyslipidemia. Metabolism. 2008; 57: 1711-8.

  • Kodama M. Kitadai Y. Tanaka M. Kuwai T. Tanaka S. Oue N. Yasui W, and Chayama K, Vascular endothelial growth factor C stimulates progression of human gastric cancer via both autocrine and paracrine mechanisms. Clin Cancer Res. 2008; 14: 7205-14.

  • Kuroda T. Ito M. Wada Y. Kitadai Y. Tanaka S. Yoshida K. Yoshihara M. Haruma K. Merdh S, and Chayama K, Presence of poorly differentiated component correlated with submucosal invasion in the early diffuse-type gastric cancer. Hepatogastroenterology. 2008; 55: 2264-8.

  • Umemura T. Soga J. Hidaka T. Takemoto H. Nakamura S. Jitsuiki D. Nishioka K. Goto C. Teragawa H. Yoshizumi M. Chayama K, and Higashi Y, Aging and hypertension are independent risk factors for reduced number of circulating endothelial progenitor cells. Am J Hypertens. 2008; 21: 1203-9.

  • Tashiro H. Itamoto T. Fudaba Y. Ohdan H. Fukuda S. Kohashi T. Amano H. Ishiyama K. Ide K. Ogawa T. Shishida M. Irei T. Ushitora Y. Ohira M. Takahashi S. Chayama K, and Asahara T, Prophylaxis against recurrence of HBV hepatitis after living-donor liver transplantation. Hepatogastroenterology. 2008; 55: 1746-9.

  • Nakao M. Yoshida S. Tanaka S. Takemura Y. Oka S. Yoshihara M, and Chayama K, Optical biopsy of early gastroesophageal cancer by catheter-based reflectance-type laser-scanning confocal microscopy. J Biomed Opt. 2008; 13: 054043.

  • Kimura T. Imamura M. Hiraga N. Hatakeyama T. Miki D. Noguchi C. Mori N. Tsuge M. Takahashi S. Fujimoto Y. Iwao E. Ochi H. Abe H. Maekawa T. Arataki K. Tateno C. Yoshizato K. Wakita T. Okamoto T. Matsuura Y, and Chayama K, Establishment of an infectious genotype 1b hepatitis C virus clone in human hepatocyte chimeric mice. J Gen Virol. 2008; 89: 2108-13.

  • Hiramatsu A. Takahashi S. Aikata H. Azakami T. Katamura Y. Kawaoka T. Uka K. Yamashina K. Takaki S. Kodama H. Jeong S C. Imamura M. Kawakami Y, and Chayama K, Etiology and outcome of acute liver failure: retrospective analysis of 50 patients treated at a single center. J Gastroenterol Hepatol. 2008; 23: 1216-22.

  • Soga J. Nakamura S. Nishioka K. Umemura T. Jitsuiki D. Hidaka T. Teragawa H. Takemoto H. Goto C. Yoshizumi M. Chayama K, and Higashi Y, Relationship between augmentation index and flow-mediated vasodilation in the brachial artery. Hypertension Research. 2008; 31: 1293-8.

  • Teragawa H. Ueda K. Okuhara K. Kuwashima R. Fukuda Y. Kiguchi M. Taniguchi K. Higashi Y. Oshima T. Yoshizumi M, and Chayama K, Coronary vasospasm produces reversible perfusion defects observed during adenosine triphosphate stress myocardial single-photon emission computed tomography. Clin Cardiol. 2008; 31: 310-6.

  • Imagawa S. Yoshihara M. Ito M. Yoshida S. Wada Y. Tatsugami M. Takamura A. Tanaka S. Haruma K, and Chayama K, Evaluation of gastric cancer risk using topography of histological gastritis: a large-scaled cross-sectional study. Dig Dis Sci. 2008; 53: 1818-23.

  • Nonaka M. Tazuma S. Hyogo H. Kanno K, and Chayama K, Cytoprotective effect of tauroursodeoxycholate on hepatocyte apoptosis induced by peroxisome proliferator-activated receptor gamma ligand. J Gastroenterol Hepatol. 2008; 23: e198-206.

  • Yamamoto Y. Watari Y. Brydun A. Yoshizumi M. Akishita M. Horiuchi M. Chayama K. Oshima T, and Ozono R, Role of the angiotensin II type 2 receptor in arterial remodeling after wire injury in mice. Hypertension Research. 2008; 31: 1241-9.

  • Hiyama T. Yoshihara M. Tanaka S. Haruma K, and Chayama K, Strategy for treatment of nonerosive reflux disease in Asia. World J Gastroenterol. 2008; 14: 3123-8.

  • Hiyama T. Yoshihara M. Tanaka S, and Chayama K, Genetic polymorphisms and head and neck cancer risk (Review). Int J Oncol. 2008; 32: 945-73.

  • Abe K. Nakashima H. Ishida M. Miho N. Sawano M. Soe N N. Kurabayashi M. Chayama K. Yoshizumi M, and Ishida T, Angiotensin II-induced osteopontin expression in vascular smooth muscle cells involves Gq/11, Ras, ERK, Src and Ets-1. Hypertension Research. 2008; 31: 987-98.

  • Uka K. Aikata H. Takaki S. Kawaoka T. Saneto H. Miki D. Takahashi S. Toyota N. Ito K, and Chayama K, Systemic gemcitabine combined with intra-arterial low-dose cisplatin and 5-fluorouracil for advanced hepatocellular carcinoma: seven cases. World J Gastroenterol. 2008; 14: 2602-8.

  • Watari Y. Yamamoto Y. Brydun A. Ishida T. Mito S. Yoshizumi M. Igarashi K. Chayama K. Ohshima T, and Ozono R, Ablation of the bach1 gene leads to the suppression of atherosclerosis in bach1 and apolipoprotein E double knockout mice. Hypertension Research. 2008; 31: 783-92.

  • Ohishi W. Fujiwara S. Cologne J B. Suzuki G. Akahoshi M. Nishi N. Takahashi I, and Chayama K, Risk factors for hepatocellular carcinoma in a Japanese population: a nested case-control study. Cancer Epidemiol Biomarkers Prev. 2008; 17: 846-54.

  • Kodama M. Kitadai Y. Shishido T. Shimamoto M. Fukumoto A. Masuda H. Tanaka S. Yoshihara M. Sakai A. Nakayama H, and Chayama K, Primary follicular lymphoma of the gastrointestinal tract: a retrospective case series. Endoscopy. 2008; 40: 343-6.

  • Jeong S. Kawakami Y. Kitamoto M. Ishihara H. Tsuji K. Aimitsu S. Kawakami H. Uka K. Takaki S. Kodama H. Waki K. Imamura M. Aikata H. Takahashi S, and Chayama K, Prospective study of short-term peginterferon-alpha-2a monotherapy in patients who had a virological response at 2 weeks after initiation of interferon therapy. J Gastroenterol Hepatol. 2008; 23: 541-5.

  • Kamino D. Manabe N. Hata J. Haruma K. Tanaka S, and Chayama K, Long-term Ultrasonographic Follow-up Study of Gastric Motility in Patients with Functional Dyspepsia. J Clin Biochem Nutr. 2008; 42: 144-9.

  • Higashi Y. Goto C. Jitsuiki D. Umemura T. Nishioka K. Hidaka T. Takemoto H. Nakamura S. Soga J. Chayama K. Yoshizumi M, and Taguchi A, Periodontal infection is associated with endothelial dysfunction in healthy subjects and hypertensive patients. Hypertension. 2008; 51: 446-53.

  • Utoh R. Tateno C. Yamasaki C. Hiraga N. Kataoka M. Shimada T. Chayama K, and Yoshizato K, Susceptibility of chimeric mice with livers repopulated by serially subcultured human hepatocytes to hepatitis B virus. Hepatology. 2008; 47: 435-46.

  • Kanao H. Tanaka S. Oka S. Kaneko I. Yoshida S. Arihiro K. Yoshihara M, and Chayama K, Clinical significance of type V(I) pit pattern subclassification in determining the depth of invasion of colorectal neoplasms. World J Gastroenterol. 2008; 14: 211-7.

  • Hiyama T. Yoshihara M. Tanaka S, and Chayama K, The number of criminal prosecutions against physicians due to medical negligence is on the rise in Japan. Am J Emerg Med. 2008; 26: 105-6.

  • Kawaoka T. Takahashi S. Aikata H. Azakami T. Saneto H. Takaki S. Jeong S C. Asahara T. Ito K, and Chayama K, Beneficial effects of living-donor liver transplantation on esophageal varices. J Gastroenterol. 2008; 43: 982-9.

  • Ito M. Tanaka S. Maeda M. Takamura A. Tatsugami M. Wada Y. Matsumoto Y. Yoshihara M. Haruma K, and Chayama K, Role of the gastrin-gastrin receptor system in the expansive growth of human gastric neoplasms. Digestion. 2008; 78: 163-70.

  • Ishida H. Wong J B. Hino K. Kurokawa F. Nishina S. Sakaida I. Okita K. Tamesa T. Oka M. Torimura T. Sata M. Takahashi S. Chayama K, and Inoue Y, Validating a Markov model of treatment for hepatitis C virus-related hepatocellular carcinoma. Methods Inf Med. 2008; 47: 529-40.

  • Tanaka S. Oka S, and Chayama K, Colorectal endoscopic submucosal dissection: present status and future perspective, including its differentiation from endoscopic mucosal resection. J Gastroenterol. 2008; 43: 641-51.

  • Uka K. Aikata H. Mori N. Takaki S. Kawakami Y. Azakami T. Kawaoka T. Jeong S C. Takahashi S, and Chayama K, Combination therapy of oral fluoropyrimidine anticancer drug S-1 and interferon alpha for HCC patients with extrahepatic metastases. Oncology. 2008; 75: 8-16.

  • Miki D. Aikata H. Uka K. Saneto H. Kawaoka T. Azakami T. Takaki S. Jeong S C. Imamura M. Kawakami Y. Takahashi S. Itamoto T. Asahara T. Arihiro K, and Chayama K, Clinicopathological features of elderly patients with hepatitis C virus-related hepatocellular carcinoma. J Gastroenterol. 2008; 43: 550-7.

  • Matsumoto Y. Ito M. Kamino D. Tanaka S. Haruma K, and Chayama K, Relation between histologic gastritis and gastric motility in Japanese patients with functional dyspepsia: evaluation by transabdominal ultrasonography. J Gastroenterol. 2008; 43: 332-7.

  • Iwamoto K. Kanno K. Hyogo H. Yamagishi S. Takeuchi M. Tazuma S, and Chayama K, Advanced glycation end products enhance the proliferation and activation of hepatic stellate cells. J Gastroenterol. 2008; 43: 298-304.

  • Nakao M. Hata J. Manabe N. Okanobu H. Tanaka S. Haruma K, and Chayama K, Evaluation of colon cancer vascularity by flash echo imaging. Scand J Gastroenterol. 2008; 43: 223-8.

  • Suenari K. Shiode N. Shirota K. Ishii H. Goto K. Sairaku A. Mikami S. Nakano Y, and Chayama K, Predictors and long-term prognostic implications of angiographic slow/no-flow during percutaneous coronary intervention for acute myocardial infarction. Intern Med. 2008; 47: 899-906.

  • Tsuge M. Noguchi C. Hiraga N. Mori N. Hiramatsu A. Imamura M. Ohishi W. Arataki K. Aikata H. Kawakami Y. Takahashi S, and Chayama K, A case of fulminant hepatic failure caused by hepatitis E virus. Clinical Journal of Gastroenterology. 2008; 1: 69-74.

  • Oka S. Tanaka S. Fukumoto A, and Chayama K, Endoscopic Ultrasonography with Double Balloon Enteroscopy for Small Bowel Diseases. Techniques in Gastrointestinal Endoscopy. 2008; 10: 113-118.

  • Shinji Tanaka S O, Kazuaki Chayama, Strategy of Endoscopic Treatment for Colorectal Tumor: Recent Progress and Perspective. New Challenges in Gastrointestinal Endoscopy. 2008 353-366.

  • Teragawa H N K, Fujii Y, Mitsuba N, Makita Y, Fujimura N, Hata T, Idei N, Nakata A, Okuhara K, Watari Y, Higashi Y, SHingu TJapanese Journai of Interventional Cardiology, Chayama K, Kiharra Y, Acute Myocardial Infarction,in which the Culprit Lesion was within the Stented Portion,occurring Nine Years after Implantation of a Bare Metal Stent. Japanese Journai of Interventional Cardiology. 2008; 23: 376-380.

  • Matsumoto T. Kudo T. Esaki M. Yano T. Yamamoto H. Sakamoto C. Goto H. Nakase H. Tanaka S. Matsui T. Sugano K, and Iida M, Prevalence of non-steroidal anti-inflammatory drug-induced enteropathy determined by double-balloon endoscopy: a Japanese multicenter study. Scand J Gastroenterol. 2008; 43: 490-6.

  • Sumida T K Y, Masuda H, Shinagawa K, Tanaka M, Kodama M, Kuroda T, Hiyama T, Tanaka S, Nakayama H, Yoshihara M, Yoshino T, Chayama K, Rapid progression of Epstein -Barr-virus-positive gastric diffuse large B-cell lymphoma during chemoradiotherapy: a case report. Clin J Gastroenterol. 2008; 1: 105-109.

  • Hirota M T T, Kaneda K, Yoshida S, Tanaka S, Feature extraction from images of endoscopic large intestine. Korea-Japan Joint Workshop on Frontiers of Computer Vision (FCV2008). 2008; 1: 100-105.