広島大学大学院医歯薬保健学研究科

消化器⋅代謝内科学

(広島大学病院 旧第一内科)

業績・活動

主要業績

主要業績

  • Mitsui K. Tanaka S. Yamamoto H. Kobayashi T. Ehara A. Yano T. Goto H. Nakase H. Tanaka S. Matsui T. Iida M. Sugano K, and Sakamoto C, Role of double-balloon endoscopy in the diagnosis of small-bowel tumors: the first Japanese multicenter study. Gastrointest Endosc, 2009; 70: 498-504.

  • Qi G. Tuncel H. Aoki E. Tanaka S. Oka S. Kaneko I. Okamoto M. Tatsuka M. Nakai S, and Shimamoto F, Intracellular localization of survivin determines biological behavior in colorectal cancer. Oncol Rep, 2009; 22: 557-62.

  • Oue N. Sentani K. Noguchi T. Ohara S. Sakamoto N. Hayashi T. Anami K. Motoshita J. Ito M. Tanaka S. Yoshida K, and Yasui W, Serum olfactomedin 4 (GW112, hGC-1) in combination with Reg IV is a highly sensitive biomarker for gastric cancer patients. Int J Cancer, 2009; 125: 2383-92.

  • Rey J F. Tanaka S. Lambert R, and Tajiri H, Evaluation of the clinical outcomes associated with EXERA II and LUCERA endoscopes. Dig Endosc, 2009; 21 Suppl 1: S113-20.

  • Yamamoto H. Kitadai Y. Yamamoto H. Oue N. Ohdan H. Yasui W, and Kikuchi A, Laminin gamma2 mediates Wnt5a-induced invasion of gastric cancer cells. Gastroenterology, 2009; 137: 242-52, 252.e1-6.

  • Lambert R. Kudo S E. Vieth M. Allen J I. Fujii H. Fujii T. Kashida H. Matsuda T. Mori M. Saito H. Shimoda T. Tanaka S. Watanabe H. Sung J J. Feld A D. Inadomi J M. O'Brien M J. Lieberman D A. Ransohoff D F. Soetikno R M. Zauber A. Teixeira C R. Rey J F. Jaramillo E. Rubio C A. Van Gossum A. Jung M. Jass J R, and Triadafilopoulos G, Pragmatic classification of superficial neoplastic colorectal lesions. Gastrointest Endosc, 2009; 70: 1182-99.

  • Hamada T. Yokota K. Ayada K. Hirai K. Kamada T. Haruma K. Chayama K, and Oguma K, Detection of Helicobacter hepaticus in human bile samples of patients with biliary disease. Helicobacter, 2009; 14: 545-51.

  • Abe H. Ochi H. Maekawa T. Hatakeyama T. Tsuge M. Kitamura S. Kimura T. Miki D. Mitsui F. Hiraga N. Imamura M. Fujimoto Y. Takahashi S. Nakamura Y. Kumada H, and Chayama K, Effects of structural variations of APOBEC3A and APOBEC3B genes in chronic hepatitis B virus infection. Hepatol Res, 2009; 39: 1159-68.

  • Hiraga N. Imamura M. Hatakeyama T. Kitamura S. Mitsui F. Tanaka S. Tsuge M. Takahashi S. Abe H. Maekawa T. Ochi H. Tateno C. Yoshizato K. Wakita T, and Chayama K, Absence of viral interference and different susceptibility to interferon between hepatitis B virus and hepatitis C virus in human hepatocyte chimeric mice. J Hepatol, 2009; 51: 1046-54.

  • Ohira M. Ishiyama K. Tanaka Y. Doskali M. Igarashi Y. Tashiro H. Hiraga N. Imamura M. Sakamoto N. Asahara T. Chayama K, and Ohdan H, Adoptive immunotherapy with liver allograft-derived lymphocytes induces anti-HCV activity after liver transplantation in humans and humanized mice. J Clin Invest, 2009; 119: 3226-35.

  • Higashi Y. Goto C. Hidaka T. Soga J. Nakamura S. Fujii Y. Hata T. Idei N. Fujimura N. Chayama K. Kihara Y, and Taguchi A, Oral infection-inflammatory pathway, periodontitis, is a risk factor for endothelial dysfunction in patients with coronary artery disease. Atherosclerosis, 2009; 206: 604-10.

  • Hiyama T. Matsuo K. Urabe Y. Fukuhara T. Tanaka S. Yoshihara M. Haruma K, and Chayama K, Meta-analysis used to identify factors associated with the effectiveness of proton pump inhibitors against non-erosive reflux disease. J Gastroenterol Hepatol, 2009; 24: 1326-32.

  • Tahara H. Tanaka Y. Ishiyama K. Ide K. Shishida M. Irei T. Ushitora Y. Ohira M. Banshodani M. Tashiro H. Itamoto T. Asahara T. Imamura M. Takahashi S. Chayama K, and Ohdan H, Successful hepatitis B vaccination in liver transplant recipients with donor-specific hyporesponsiveness. Transpl Int, 2009; 22: 805-13.

  • Matsumura T. Hu Z. Kato T. Dreux M. Zhang Y Y. Imamura M. Hiraga N. Juteau J M. Cosset F L. Chayama K. Vaillant A, and Liang T J, Amphipathic DNA polymers inhibit hepatitis C virus infection by blocking viral entry. Gastroenterology, 2009; 137: 673-81.

  • Oka S. Tanaka S. Kanao H. Oba S, and Chayama K, Therapeutic strategy for colorectal laterally spreading tumor. Dig Endosc, 2009; 21 Suppl 1: S43-6.

  • Tanaka S. Oka S. Chayama K, and Kawashima K, Knack and practical technique of colonoscopic treatment focused on endoscopic mucosal resection using snare. Dig Endosc, 2009; 21 Suppl 1: S38-42.

  • Yotsuyanagi H. Kikuchi Y. Tsukada K. Nishida K. Kato M. Sakai H. Takamatsu J. Hige S. Chayama K. Moriya K, and Koike K, Chronic hepatitis C in patients co-infected with human immunodeficiency virus in Japan: a retrospective multicenter analysis. Hepatol Res, 2009; 39: 657-63.

  • Kawaoka T. Aikata H. Takaki S. Katamura Y. Hiramatsu A. Waki K. Takahashi S. Hieda M. Toyota N. Ito K, and Chayama K, Transarterial infusion chemotherapy using cisplatin-lipiodol suspension with or without embolization for unresectable hepatocellular carcinoma. Cardiovasc Intervent Radiol, 2009; 32: 687-94.

  • Noguchi C. Imamura M. Tsuge M. Hiraga N. Mori N. Miki D. Kimura T. Takahashi S. Fujimoto Y. Ochi H. Abe H. Maekawa T. Tateno C. Yoshizato K, and Chayama K, G-to-A hypermutation in hepatitis B virus (HBV) and clinical course of patients with chronic HBV infection. J Infect Dis, 2009; 199: 1599-607.

  • Soe N N. Ishida T. Ishida M. Sawano M. Abe K. Miho N. Chayama K. Kihara Y, and Yoshizumi M, Nifedipine interferes with migration of vascular smooth muscle cells via inhibition of Pyk2-Src axis. J Atheroscler Thromb, 2009; 16: 230-8.

  • Nabeshima Y. Tazuma S. Kanno K. Hyogo H, and Chayama K, Deletion of angiotensin II type I receptor reduces hepatic steatosis. J Hepatol, 2009; 50: 1226-35.

  • Sumida T. Kitadai Y. Hiyama T. Shinagawa K. Tanaka M. Kodama M. Masuda H. Ito M. Tanaka S. Yoshihara M, and Chayama K, Antibodies to Helicobacter pylori and CagA protein are associated with the response to antibacterial therapy in patients with H. pylori-positive API2-MALT1-negative gastric MALT lymphoma. Cancer Sci, 2009; 100: 1075-81.

  • Tsuji K. Kawakami Y. Aimitsu S. Kohno H. Aisaka Y. Kimura S. Nagata S. Ohgoshi H. Kitamoto M. Hidaka T. Kawakami H. Nakanishi T, and Chayama K, Predicting the response to 48-week combination therapy with peginterferon alpha-2b plus ribavirin from the estimated HCV RNA load index after negative serum change in genotype 1b hepatitis C patients. Hepatol Res, 2009; 39: 531-8.

  • Shindo M. Chayama K. Mochida S. Toyota J. Tomita E. Kumada H. Yokosuka O. Sata M. Hayashi N. Suzuki K. Okanoue T. Tsubouchi H. Ishikawa H. Seriu T, and Omata M, Antiviral activity, dose-response relationship, and safety of entecavir following 24-week oral dosing in nucleoside-naive Japanese adult patients with chronic hepatitis B: a randomized, double-blind, phase II clinical trial. Hepatol Int, 2009; 3: 445-52.

  • Wada Y. Ito M. Takata S. Kitamura S. Takamura A. Tatsugami M. Imagawa S. Matsumoto Y. Tanaka S. Yoshihara M, and Chayama K, Little necessity of acid inhibition against proton pump inhibitor rebound effects and prior helicobacter pylori eradication therapy in gastric ulcer patients: a randomized prospective study. Hepatogastroenterology, 2009; 56: 624-8.

  • Tsukada H. Ochi H. Maekawa T. Abe H. Fujimoto Y. Tsuge M. Takahashi H. Kumada H. Kamatani N. Nakamura Y, and Chayama K, A polymorphism in MAPKAPK3 affects response to interferon therapy for chronic hepatitis C. Gastroenterology, 2009; 136: 1796-805 e6.

  • Mouri R. Yoshida S. Tanaka S. Oka S. Yoshihara M, and Chayama K, Evaluation and validation of computed virtual chromoendoscopy in early gastric cancer. Gastrointest Endosc, 2009; 69: 1052-8.

  • Kamatani Y. Wattanapokayakit S. Ochi H. Kawaguchi T. Takahashi A. Hosono N. Kubo M. Tsunoda T. Kamatani N. Kumada H. Puseenam A. Sura T. Daigo Y. Chayama K. Chantratita W. Nakamura Y, and Matsuda K, A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nat Genet, 2009; 41: 591-5.

  • Urabe Y. Hiyama T. Tanaka S. Oka S. Yoshihara M. Arihiro K, and Chayama K, Metachronous multiple esophageal squamous cell carcinomas and Lugol-voiding lesions after endoscopic mucosal resection. Endoscopy, 2009; 41: 304-9.

  • Nakamura S. Kimura M. Goto C. Noma K. Yoshizumi M. Chayama K. Kihara Y, and Higashi Y, Cigarette smoking abolishes ischemic preconditioning-induced augmentation of endothelium-dependent vasodilation. Hypertension, 2009; 53: 674-81.

  • Hiyama T. Yoshihara M. Tanaka S. Haruma K, and Chayama K, Effectiveness of prokinetic agents against diseases external to the gastrointestinal tract. J Gastroenterol Hepatol, 2009; 24: 537-46.

  • Katamura Y. Aikata H. Kimura Y. Azakami T. Kawaoka T. Takaki S. Waki K. Hiramatsu A. Kawakami Y. Takahashi S, and Chayama K, Successful treatment of pulmonary metastases associated with advanced hepatocellular carcinoma by systemic 5-fluorouracil combined with interferon-alpha in a hemodialysis patient. Hepatol Res, 2009; 39: 415-20.

  • Fukumoto A. Tanaka S. Shishido T. Takemura Y. Oka S, and Chayama K, Comparison of detectability of small-bowel lesions between capsule endoscopy and double-balloon endoscopy for patients with suspected small-bowel disease. Gastrointest Endosc, 2009; 69: 857-65.

  • Mouri R. Yoshida S. Tanaka S. Oka S. Yoshihara M, and Chayama K, Usefulness of endoscopic ultrasonography in determining the depth of invasion and indication for endoscopic treatment of early gastric cancer. J Clin Gastroenterol, 2009; 43: 318-22.

  • Mori N. Imamura M. Kawakami Y. Saneto H. Kawaoka T. Takaki S. Aikata H. Takahashi S. Chayama K, and Hiroshima Liver Study G, Randomized trial of high-dose interferon-alpha-2b combined with ribavirin in patients with chronic hepatitis C: Correlation between amino acid substitutions in the core/NS5A region and virological response to interferon therapy. J Med Virol, 2009; 81: 640-9.

  • Kanao H. Tanaka S. Oka S. Hirata M. Yoshida S, and Chayama K, Narrow-band imaging magnification predicts the histology and invasion depth of colorectal tumors. Gastrointest Endosc, 2009; 69: 631-6.

  • Mitsui F. Aikata H. Azakami T. Katamura Y. Kimura T. Kawaoka T. Saneto H. Takaki S. Hiraga N. Tsuge M. Waki K. Hiramatsu A. Imamura M. Kawakami Y. Takahashi S. Arihiro K, and Chayama K, The first Japanese case of COACH syndrome. Hepatol Res, 2009; 39: 318-23.

  • Kawaoka T. Kawakami Y. Tsuji K. Ito H. Kitamoto M. Aimitsu S. Kawakami H. Jeong S C. Imamura M. Aikata H. Takahashi S, and Chayama K, Dose comparison study of pegylated interferon-alpha-2b plus ribavirin in naive Japanese patients with hepatitis C virus genotype 2: a randomized clinical trial. J Gastroenterol Hepatol, 2009; 24: 366-71.

  • Kawaoka T. Aikata H. Takaki S. Uka K. Azakami T. Saneto H. Jeong S C. Kawakami Y. Takahashi S. Toyota N. Ito K. Hirokawa Y, and Chayama K, FDG positron emission tomography/computed tomography for the detection of extrahepatic metastases from hepatocellular carcinoma. Hepatol Res, 2009; 39: 134-42.

  • Ohira M. Ishifuro M. Ide K. Irei T. Tashiro H. Itamoto T. Ito K. Chayama K. Asahara T, and Ohdan H, Significant correlation between spleen volume and thrombocytopenia in liver transplant patients: a concept for predicting persistent thrombocytopenia. Liver Transpl, 2009; 15: 208-15.

  • Hirata D. Yamabuki T. Miki D. Ito T. Tsuchiya E. Fujita M. Hosokawa M. Chayama K. Nakamura Y, and Daigo Y, Involvement of epithelial cell transforming sequence-2 oncoantigen in lung and esophageal cancer progression. Clin Cancer Res, 2009; 15: 256-66.

  • Hiyama T. Yoshihara M. Tanaka S, and Chayama K, Trend in Japanese malpractice litigation involving gastrointestinal endoscopy. Am J Gastroenterol, 2009; 104: 251-2.

  • Kodama H. Aikata H. Takaki S. Takahashi S. Toyota N. Ito K, and Chayama K, Evaluation of patients with esophageal varices after endoscopic injection sclerotherapy using multiplanar reconstruction MDCT images. AJR Am J Roentgenol, 2009; 192: 122-30.

  • Yamaguchi T. Yoshida S. Tanaka S. Takemura Y. Oka S. Yoshihara M. Yamada H, and Chayama K, Predicting the clinical response to cytapheresis in steroid-refractory or -dependent ulcerative colitis using contrast-enhanced ultrasonography. Scand J Gastroenterol, 2009; 44: 831-7.

  • Matsumoto Y. Ito M. Tsuge M. Matsuo T. Tanaka S. Haruma K, and Chayama K, Ecabet sodium induces neuronal nitric oxide synthase-derived nitric oxide synthesis and gastric adaptive relaxation in the human stomach. J Gastroenterol, 2009; 44: 1118-24.

  • Takata S. Ito M. Wada Y. Yoshihara M. Tanaka S, and Chayama K, Pathogenetic role of the tyrosine-phosphorylated CagA EPIYA sequence of Helicobacter pylori in histological gastritis in Japanese patients. J Gastroenterol, 2009; 44: 405-11.

  • Ito M. Takata S. Tatsugami M. Wada Y. Imagawa S. Matsumoto Y. Takamura A. Kitamura S. Matsuo T. Tanaka S. Haruma K, and Chayama K, Clinical prevention of gastric cancer by Helicobacter pylori eradication therapy: a systematic review. J Gastroenterol, 2009; 44: 365-71.

  • Fukumoto A. Tanaka S. Imagawa H. Shishido T. Oka S. Yoshida S. Yamada H, and Chayama K, Usefulness and limitations of transabdominal ultrasonography for detecting small-bowel tumors. Scand J Gastroenterol, 2009; 44: 332-8.

  • Okanoue T. Itoh Y. Hashimoto H. Yasui K. Minami M. Takehara T. Tanaka E. Onji M. Toyota J. Chayama K. Yoshioka K. Izumi N. Akuta N, and Kumada H, Predictive values of amino acid sequences of the core and NS5A regions in antiviral therapy for hepatitis C: a Japanese multi-center study. J Gastroenterol, 2009; 44: 952-63.

  • Katamura Y. Aikata H. Takaki S. Azakami T. Kawaoka T. Waki K. Hiramatsu A. Kawakami Y. Takahashi S. Kenjo M. Toyota N. Ito K, and Chayama K, Intra-arterial 5-fluorouracil/interferon combination therapy for advanced hepatocellular carcinoma with or without three-dimensional conformal radiotherapy for portal vein tumor thrombosis. J Gastroenterol, 2009; 44: 492-502.

  • Ohishi W and Chayama K, Current treatment for chronic hepatitis B in Japan. Clinical Journal of Gastroenterology, 2009; 2: 325-330.

  • Kawase R. Nagata S. Onoyama M. Nakayama N. Honda Y. Kuwahara K. Kimura S. Tsuji K. Ohgoshi H. Sakatani A. Kaneko M. Ito M. Shimamoto F, and Hidaka T, A case of gastric adenocarcinoma arising from a fundic gland polyp. Clinical Journal of Gastroenterology, 2009; 2: 279-283.

  • Onitake T. Ueno Y. Tanaka S. Hanaoka R. Yoshioka K. Hatakeyama T. Oka S. Yoshida S. Hiyama T. Ito M. Kitadai Y. Yoshihara M, and Chayama K, Cheilitis granulomatosa as an early manifestation of Crohn's disease. Clinical Journal of Gastroenterology, 2009; 2: 190-193.

  • Ueno Y. Tanaka S. Onitake T. Hanaoka R. Yoshioka K. Ito M, and Chayama K, Infliximab treatment for Crohn's disease in a patient with IgA nephropathy. Clinical Journal of Gastroenterology, 2009; 2: 380-383.

  • Waka Ohishi K C, Current treatment for chronic hepatitis B in Japan. Clinical Journal of Gastroenterology, 2009; 2: 325-330