広島大学大学院医歯薬保健学研究科

消化器⋅代謝内科学

(広島大学病院 旧第一内科)

業績・活動

主要業績

主要業績

  • Tari A. Sato Y. Asaoku H. Kunihiro M. Fukumoto A. Tanaka S. Fujihara M, and Yoshino T, A duodenal follicular lymphoma associated with the lesion mimicking MALT lymphoma in terminal ileum and Bauhin valve. Med Mol Morphol, 2010; 43: 174-7.

  • Hyodo I. Suzuki H. Takahashi K. Saito Y. Tanaka S. Chiu H M. Kim N K. Li J. Lim R. Villalon A, and Boku N, Present status and perspectives of colorectal cancer in Asia: Colorectal Cancer Working Group report in 30th Asia-Pacific Cancer Conference. Jpn J Clin Oncol, 2010; 40 Suppl 1: i38-43.

  • Oka S. Tanaka S. Kanao H. Ishikawa H. Watanabe T. Igarashi M. Saito Y. Ikematsu H. Kobayashi K. Inoue Y. Yahagi N. Tsuda S. Simizu S. Iishi H. Yamano H. Kudo S E. Tsuruta O. Tamura S. Saito Y. Cho E. Fujii T. Sano Y. Nakamura H. Sugihara K, and Muto T, Current status in the occurrence of postoperative bleeding, perforation and residual/local recurrence during colonoscopic treatment in Japan. Dig Endosc, 2010; 22: 376-80.

  • Taddei T H. Dziura J. Chen S. Yang R. Hyogo H. Sullards C. Cohen D E. Pastores G, and Mistry P K, High incidence of cholesterol gallstone disease in type 1 Gaucher disease: characterizing the biliary phenotype of type 1 Gaucher disease. J Inherit Metab Dis, 2010; 33: 291-300.

  • Tanaka S. Tamegai Y. Tsuda S. Saito Y. Yahagi N, and Yamano H O, Multicenter questionnaire survey on the current situation of colorectal endoscopic submucosal dissection in Japan. Dig Endosc, 2010; 22 Suppl 1: S2-8.

  • Hirai F. Matsui T. Aoyagi K. Inoue N. Hibi T. Oshitani N. Fujii H. Kobayashi K. Suzuki Y, and Tanaka S, Validity of activity indices in ulcerative colitis: comparison of clinical and endoscopic indices. Dig Endosc, 2010; 22: 39-44.

  • Kitadai Y, Cancer-stromal cell interaction and tumor angiogenesis in gastric cancer. Cancer Microenviron, 2010; 3: 109-16.

  • Akuta N. Suzuki F. Hirakawa M. Kawamura Y. Yatsuji H. Sezaki H. Suzuki Y. Hosaka T. Kobayashi M. Kobayashi M. Saitoh S. Arase Y. Ikeda K. Chayama K. Nakamura Y, and Kumada H, Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin. Hepatology, 2010; 52: 421-9.

  • Hotta K. Yoneda M. Hyogo H. Ochi H. Mizusawa S. Ueno T. Chayama K. Nakajima A. Nakao K, and Sekine A, Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease. BMC Med Genet, 2010; 11: 172.

  • Katamura Y. Aikata H. Hashimoto Y. Kimura Y. Kawaoka T. Takaki S. Waki K. Hiramatsu A. Kawakami Y. Takahashi S. Kenjo M, and Chayama K, Zoledronic acid delays disease progression of bone metastases from hepatocellular carcinoma. Hepatol Res, 2010; 40: 1195-203.

  • Chayama K. Hayes C N. Yoshioka K. Moriwaki H. Okanoue T. Sakisaka S. Takehara T. Oketani M. Toyota J. Izumi N. Hiasa Y. Matsumoto A. Nomura H. Seike M. Ueno Y. Yotsuyanagi H, and Kumada H, Accumulation of refractory factors for pegylated interferon plus ribavirin therapy in older female patients with chronic hepatitis C. Hepatol Res, 2010; 40: 1155-1167.

  • Imagawa S. Ito M. Yoshihara M. Eguchi H. Tanaka S, and Chayama K, Helicobacter pylori dupA and gastric acid secretion are negatively associated with gastric cancer development. J Med Microbiol, 2010; 59: 1484-9.

  • Sanomura Y. Oka S. Tanaka S. Higashiyama M. Yoshida S. Arihiro K. Shimamoto F, and Chayama K, Predicting the absence of lymph node metastasis of submucosal invasive gastric cancer: expansion of the criteria for curative endoscopic resection. Scand J Gastroenterol, 2010; 45: 1480-7.

  • Kawaoka T. Hiraga N. Takahashi S. Takaki S. Mitsui F. Tsuge M. Nagaoki Y. Kimura Y. Hashimoto Y. Katamura Y. Hiramatsu A. Waki K. Imamura M. Kawakami Y. Aikata H. Tashiro H. Ohdan H, and Chayama K, Prolongation of interferon therapy for recurrent hepatitis C after living donor liver transplantation: analysis of predictive factors of sustained virological response, including amino acid sequence of the core and NS5A regions of hepatitis C virus. Scand J Gastroenterol, 2010; 45: 1488-96.

  • Shinagawa K. Kitadai Y. Tanaka M. Sumida T. Kodama M. Higashi Y. Tanaka S. Yasui W, and Chayama K, Mesenchymal stem cells enhance growth and metastasis of colon cancer. Int J Cancer, 2010; 127: 2323-33.

  • Suda G. Sakamoto N. Itsui Y. Nakagawa M. Tasaka-Fujita M. Funaoka Y. Watanabe T. Nitta S. Kiyohashi K. Azuma S. Kakinuma S. Tsuchiya K. Imamura M. Hiraga N. Chayama K, and Watanabe M, IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones. Virology, 2010; 407: 80-90.

  • Sakano A. Yanai H. Sakaguchi E. Tanioka Y. Yahara N. Hayashi H. Murakami T, and Chayama K, Clinical impact of tumor invasion depth staging of esophageal squamous cell carcinoma using endoscopic ultrasonography. Hepatogastroenterology, 2010; 57: 1423-9.

  • Takemura Y. Yoshida S. Tanaka S. Onji K. Oka S. Tamaki T. Kaneda K. Yoshihara M, and Chayama K, Quantitative analysis and development of a computer-aided system for identification of regular pit patterns of colorectal lesions. Gastrointest Endosc, 2010; 72: 1047-51.

  • Kawaoka T. Aikata H. Takaki S. Hashimoto Y. Katamura Y. Hiramatsu A. Waki K. Takahashi S. Kamada K. Kitamoto M. Nakanishi T. Ishikawa M. Hieda M. Kakizawa H. Tanaka J, and Chayama K, Transcatheter chemoembolization for unresectable hepatocellular carcinoma and comparison of five staging systems. Hepatol Res, 2010; 40: 1082-91.

  • Matsumoto A. Tanaka S. Oba S. Kanao H. Oka S. Yoshihara M, and Chayama K, Outcome of endoscopic submucosal dissection for colorectal tumors accompanied by fibrosis. Scand J Gastroenterol, 2010; 45: 1329-37.

  • Kodama H. Aikata H. Takaki S. Azakami T. Katamura Y. Kawaoka T. Hiramatsu A. Waki K. Imamura M. Kawakami Y. Takahashi S. Toyota N. Ito K, and Chayama K, Evaluation of portosystemic collaterals by MDCT-MPR imaging for management of hemorrhagic esophageal varices. Eur J Radiol, 2010; 76: 239-45.

  • Ochi H. Maekawa T. Abe H. Hayashida Y. Nakano R. Kubo M. Tsunoda T. Hayes C N. Kumada H. Nakamura Y, and Chayama K, ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy--a genome-wide study of Japanese HCV virus patients. Gastroenterology, 2010; 139: 1190-7.

  • Tanaka M. Kitadai Y. Kodama M. Shinagawa K. Sumida T. Tanaka S. Oue N. Yasui W, and Chayama K, Potential role for vascular endothelial growth factor-D as an autocrine factor for human gastric carcinoma cells. Cancer Sci, 2010; 101: 2121-7.

  • Miki D. Kubo M. Takahashi A. Yoon K A. Kim J. Lee G K. Zo J I. Lee J S. Hosono N. Morizono T. Tsunoda T. Kamatani N. Chayama K. Takahashi T. Inazawa J. Nakamura Y, and Daigo Y, Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations. Nat Genet, 2010; 42: 893-6.

  • Mishima K. Sakamoto N. Sekine-Osajima Y. Nakagawa M. Itsui Y. Azuma S. Kakinuma S. Kiyohashi K. Kitazume A. Tsuchiya K. Imamura M. Hiraga N. Chayama K. Wakita T, and Watanabe M, Cell culture and in vivo analyses of cytopathic hepatitis C virus mutants. Virology, 2010; 405: 361-9.

  • Katamura Y. Aikata H. Hashimoto Y. Kimura Y. Kawaoka T. Takaki S. Waki K. Hiramatsu A. Kawakami Y. Takahashi S, and Chayama K, Pilot study of systemic combination therapy with S-1, an oral fluoropyrimidine, and cisplatin for hepatocellular carcinoma with extrahepatic metastases. Hepatogastroenterology, 2010; 57: 1272-8.

  • Ogi H. Nakano Y. Niida S. Dote K. Hirai Y. Suenari K. Tonouchi Y. Oda N. Makita Y. Ueda S. Kajihara K. Imai K. Sueda T. Chayama K, and Kihara Y, Is structural remodeling of fibrillated atria the consequence of tissue hypoxia? Circ J, 2010; 74: 1815-21.

  • Kodama M. Kitadai Y. Sumida T. Ohnishi M. Ohara E. Tanaka M. Shinagawa K. Tanaka S. Yasui W, and Chayama K, Expression of platelet-derived growth factor (PDGF)-B and PDGF-receptor beta is associated with lymphatic metastasis in human gastric carcinoma. Cancer Sci, 2010; 101: 1984-9.

  • Abe H. Ochi H. Maekawa T. Hayes C N. Tsuge M. Miki D. Mitsui F. Hiraga N. Imamura M. Takahashi S. Ohishi W. Arihiro K. Kubo M. Nakamura Y, and Chayama K, Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients. J Hepatol, 2010; 53: 439-43.

  • Okita K. Sakaida I. Okada M. Kaneko A. Chayama K. Kato M. Sata M. Yoshihara H. Ono N, and Murawaki Y, A multicenter, open-label, dose-ranging study to exploratively evaluate the efficacy, safety, and dose-response of tolvaptan in patients with decompensated liver cirrhosis. J Gastroenterol, 2010; 45: 979-87.

  • Oba S. Tanaka S. Oka S. Kanao H. Yoshida S. Shimamoto F, and Chayama K, Characterization of colorectal tumors using narrow-band imaging magnification: combined diagnosis with both pit pattern and microvessel features. Scand J Gastroenterol, 2010; 45: 1084-92.

  • Kawaoka T. Aikata H. Katamura Y. Takaki S. Waki K. Hiramatsu A. Takahashi S. Hieda M. Kakizawa H, and Chayama K, Hypersensitivity reactions to transcatheter chemoembolization with cisplatin and Lipiodol suspension for unresectable hepatocellular carcinoma. J Vasc Interv Radiol, 2010; 21: 1219-25.

  • Fujii Y. Soga J. Nakamura S. Hidaka T. Hata T. Idei N. Fujimura N. Nishioka K. Chayama K. Kihara Y, and Higashi Y, Classification of corkscrew collaterals in thromboangiitis obliterans (Buerger's disease): relationship between corkscrew type and prevalence of ischemic ulcers. Circ J, 2010; 74: 1684-8.

  • Mitsui F. Tsuge M. Kimura T. Kitamura S. Abe H. Saneto H. Kawaoka T. Miki D. Hatakeyama T. Hiraga N. Imamura M. Kawakami Y. Aikata H. Takahashi S. Hayes C N. Igarashi H. Morimoto K. Shimizu M, and Chayama K, Importance of serum concentration of adefovir for Lamivudine-adefovir combination therapy in patients with lamivudine-resistant chronic hepatitis B. Antimicrob Agents Chemother, 2010; 54: 3205-11.

  • Teragawa H. Mitsuba N. Nishioka K. Ueda K. Kono S. Higashi Y. Chayama K, and Kihara Y, Impaired coronary microvascular endothelial function in men with metabolic syndrome. World J Cardiol, 2010; 2: 205-10.

  • Waki K. Anno K. Ono T. Ide T. Chayama K, and Tahara H, Establishment of functional telomerase immortalized human hepatocytes and a hepatic stellate cell line for telomere-targeting anticancer drug development. Cancer Sci, 2010; 101: 1678-85.

  • Tsuge M. Hiraga N. Akiyama R. Tanaka S. Matsushita M. Mitsui F. Abe H. Kitamura S. Hatakeyama T. Kimura T. Miki D. Mori N. Imamura M. Takahashi S. Hayes C N, and Chayama K, HBx protein is indispensable for development of viraemia in human hepatocyte chimeric mice. J Gen Virol, 2010; 91: 1854-64.

  • Kamiya N. Iwao E. Hiraga N. Tsuge M. Imamura M. Takahashi S. Miyoshi S. Tateno C. Yoshizato K, and Chayama K, Practical evaluation of a mouse with chimeric human liver model for hepatitis C virus infection using an NS3-4A protease inhibitor. J Gen Virol, 2010; 91: 1668-77.

  • Kimura Y. Hyogo H. Yamagishi S. Takeuchi M. Ishitobi T. Nabeshima Y. Arihiro K, and Chayama K, Atorvastatin decreases serum levels of advanced glycation endproducts (AGEs) in nonalcoholic steatohepatitis (NASH) patients with dyslipidemia: clinical usefulness of AGEs as a biomarker for the attenuation of NASH. J Gastroenterol, 2010; 45: 750-7.

  • Ueno Y. Tanaka S, and Chayama K, Non-polypoid colorectal neoplasms in ulcerative colitis. Gastrointest Endosc Clin N Am, 2010; 20: 525-42.

  • Yokosuka O. Takaguchi K. Fujioka S. Shindo M. Chayama K. Kobashi H. Hayashi N. Sato C. Kiyosawa K. Tanikawa K. Ishikawa H. Masaki N. Seriu T, and Omata M, Long-term use of entecavir in nucleoside-naive Japanese patients with chronic hepatitis B infection. J Hepatol, 2010; 52: 791-9.

  • Hidaka T. Nakagawa K. Goto C. Soga J. Fujii Y. Hata T. Idei N. Fujimura N. Chayama K. Kihara Y, and Higashi Y, Pioglitazone improves endothelium-dependent vasodilation in hypertensive patients with impaired glucose tolerance in part through a decrease in oxidative stress. Atherosclerosis, 2010; 210: 521-4.

  • Katamura Y. Aikata H. Kimura Y. Kawaoka T. Takaki S. Waki K. Hiramatsu A. Kawakami Y. Takahashi S. Ishikawa M. Hieda M. Kakizawa H, and Chayama K, Intra-arterial 5-fluorouracil/interferon combination therapy for hepatocellular carcinoma with portal vein tumor thrombosis and extrahepatic metastases. J Gastroenterol Hepatol, 2010; 25: 1117-22.

  • Tsuge M. Noguchi C. Akiyama R. Matsushita M. Kunihiro K. Tanaka S. Abe H. Mitsui F. Kitamura S. Hatakeyama T. Kimura T. Miki D. Hiraga N. Imamura M. Takahashi S. Hayses C N, and Chayama K, G to A hypermutation of TT virus. Virus Res, 2010; 149: 211-6.

  • Nakano Y. Shimizu W. Ogi H. Suenari K. Oda N. Makita Y. Kajihara K. Hirai Y. Sairaku A. Tokuyama T. Tonouchi Y. Ueda S. Sueda T. Chayama K, and Kihara Y, A spontaneous Type 1 electrocardiogram pattern in lead V2 is an independent predictor of ventricular fibrillation in Brugada syndrome. Europace, 2010; 12: 410-6.

  • Waki K. Aikata H. Katamura Y. Kawaoka T. Takaki S. Hiramatsu A. Takahashi S. Toyota N. Ito K, and Chayama K, Percutaneous radiofrequency ablation as first-line treatment for small hepatocellular carcinoma: results and prognostic factors on long-term follow up. J Gastroenterol Hepatol, 2010; 25: 597-604.

  • Teragawa H. Morita K. Shishido H. Otsuka N. Hirokawa Y. Chayama K. Tamaki N, and Kihara Y, Impaired myocardial blood flow reserve in subjects with metabolic syndrome analyzed using positron emission tomography and N-13 labeled ammonia. Eur J Nucl Med Mol Imaging, 2010; 37: 368-76.

  • Higashi Y. Matsuoka H. Umei H. Sugano R. Fujii Y. Soga J. Kihara Y. Chayama K, and Imaizumi T, Endothelial function in subjects with isolated low HDL cholesterol: role of nitric oxide and circulating progenitor cells. Am J Physiol Endocrinol Metab, 2010; 298: E202-9.

  • Fukuhara T. Hiyama T. Tanaka S. Oka S. Yoshihara M. Arihiro K, and Chayama K, Characteristics of esophageal squamous cell carcinomas and lugol-voiding lesions in patients with head and neck squamous cell carcinoma. J Clin Gastroenterol, 2010; 44: e27-33.

  • Higashi Y. Miyazaki M. Goto C. Sanada H. Sueda T, and Chayama K, Sarpogrelate hydrochloride, a selective 5-hydroxytryptamine(2A) antagonist, augments autologous bone marrow mononuclear cell implantation-induced improvement in endothelium-dependent vasodilation in patients with critical limb ischemia. J Cardiovasc Pharmacol, 2010; 55: 56-61.

  • Kumada H. Okanoue T. Onji M. Moriwaki H. Izumi N. Tanaka E. Chayama K. Sakisaka S. Takehara T. Oketani M. Suzuki F. Toyota J. Nomura H. Yoshioka K. Seike M. Yotsuyanagi H. Ueno Y. Study Group for the Standardization of Treatment of Viral Hepatitis Including Cirrhosis M o H L, and Welfare of J, Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis C virus infection for the fiscal year 2008 in Japan. Hepatol Res, 2010; 40: 8-13.

  • Kumada H. Okanoue T. Onji M. Moriwaki H. Izumi N. Tanaka E. Chayama K. Sakisaka S. Takehara T. Oketani M. Suzuki F. Toyota J. Nomura H. Yoshioka K. Seike M. Yotsuyanagi H. Ueno Y. Study Group for the Standardization of Treatment of Viral Hepatitis Including Cirrhosis M o H L, and Welfare of J, Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis B virus infection for the fiscal year 2008 in Japan. Hepatol Res, 2010; 40: 1-7.

  • Shimomura T. Hiyama T. Tanaka S. Yoshihara M. Arihiro K, and Chayama K, Synchronous and subsequent lesions of serrated adenomas and tubular adenomas of the colorectum. Pathobiology, 2010; 77: 273-7.

  • Ide T. Sata M. Chayama K. Shindo M. Toyota J. Mochida S. Tomita E. Kumada H. Yamada G. Yatsuhashi H. Hayashi N. Ishikawa H. Seriu T, and Omata M, Evaluation of long-term entecavir treatment in stable chronic hepatitis B patients switched from lamivudine therapy. Hepatol Int, 2010; 4: 594-600.

  • Huang Y W. Chayama K. Tsuge M. Takahashi S. Hatakeyama T. Abe H. Hu J T. Liu C J. Lai M Y. Chen D S. Yang S S, and Kao J H, Differential effects of interferon and lamivudine on serum HBV RNA inhibition in patients with chronic hepatitis B. Antivir Ther, 2010; 15: 177-84.

  • Fukuhara T. Hiyama T. Tanaka S. Oka S. Yoshihara M. Arihiro K, and Chayama K, Natural course of lugol-voiding lesions in patients with superficial esophageal squamous cell carcinoma. Digestion, 2010; 82: 60-5.

  • Wada Y. Ito M. Takata S. Tanaka S. Yoshihara M, and Chayama K, Relationship between Helicobacter pylori tyrosine-phosphorylated CagA-related markers and the development of diffuse-type gastric cancers: a case-control study. Digestion, 2010; 82: 10-7.

  • Noda I. Kitamoto M. Nakahara H. Hayashi R. Okimoto T. Monzen Y. Yamada H. Imagawa M. Hiraga N. Tanaka J, and Chayama K, Regular surveillance by imaging for early detection and better prognosis of hepatocellular carcinoma in patients infected with hepatitis C virus. J Gastroenterol, 2010; 45: 105-12.

  • Kitamura S. Tsuge M. Hatakeyama T. Abe H. Imamura M. Mori N. Saneto H. Kawaoka T. Mitsui F. Hiraga N. Takaki S. Kawakami Y. Aikata H. Takahashi S. Ohishi W. Ochi H. Hayes C N, and Chayama K, Amino acid substitutions in core and NS5A regions of the HCV genome can predict virological decrease with pegylated interferon plus ribavirin therapy. Antivir Ther, 2010; 15: 1087-97.

  • Tanabe K. Urabe Y. Tokumoto N. Suzuki T. Yamamoto H. Oka S. Tanaka S, and Ohdan H, A new method for intraluminal gastrointestinal stromal tumor resection using laparoscopic seromuscular dissection technique. Dig Surg, 2010; 27: 461-5.

  • Yoshioka K. Ueno Y. Tanaka S. Nagai K. Onitake T. Hanaoka R, and Chayama K, Efficacy of ecabet sodium enema on intractable rectal ulcer after piecemeal endoscopic mucosal resection for rectal tumor. Clinical Journal of Gastroenterology, 2010; 3: 285-288.

  • Kitadai Y, Angiogenesis and lymphangiogenesis of gastric cancer. J Oncol, 2010; 2010: 468725.

  • M I, Helicobacter pylori eradication for gastric cancer prevention. Expert Rev Anticancer Ther, 2010; 10: 1-3.

  • Hyogo H. Reply to the letter By I. Tasci regarding 'Clinical usefulness of AGEs as a Biomarker for the attenuation of NASH'. J Gastroenterol. 2010; 45: 781.

  • Kim SJ BC, Kitadai Y, Nakamura T, Kuwai T, Sasaki T, Langley R, Fidler IJ. The pathogenesis of cancer metastasis: relevance to therapy. Principles of cancer biotherapy [5th edition], Springer Dordrecht Heidelberg, London New York. 2010; 17-40.

  • Kitadai Y TY. Angiogenesis and lymphangiogenesis in human gastric carcinoma. Edt. Recent advances in metastasis of gastrointestinal cancers. 2010; 9-21.

  • Kuwai T KY. Tumor - associated stroma - targeting for stromal cells in colon cancer. Recent advances in metastasis of gastrointestinal cancers. 2010; 55-64.