広島大学大学院医歯薬保健学研究科

消化器⋅代謝内科学

(広島大学病院 旧第一内科)

業績・活動

主要業績

主要業績

  • Abe H. Hayes C N. Hiraga N. Imamura M. Tsuge M. Miki D. Takahashi S. Ochi H, and Chayama K, A translational study of resistance emergence using sequential direct-acting antiviral agents for hepatitis C using ultra-deep sequencing. Am J Gastroenterol, 2013; 108: 1464-72.

  • Kato M. Terao S. Adachi K. Nakajima S. Ando T. Yoshida N. Uedo N. Murakami K. Ohara S. Ito M. Uemura N. Shimbo T. Watanabe H. Kato T. Ida K, and Study Group for Establishing Endoscopic Diagnosis of Chronic G, Changes in endoscopic findings of gastritis after cure of H. pylori infection: multicenter prospective trial. Dig Endosc, 2013; 25: 264-73.

  • Yamagishi S. Maeda S, and Hyogo H, Author reply: comment to "atorvastatin improves disease activity of nonalcoholic steatohepatitis partly through its tumour necrosis factor-alpha-lowering property". Dig Liver Dis, 2013; 45: 83-4.

  • Hayashi N. Tanaka S. Kanao H. Oka S. Yoshida S, and Chayama K, Relationship between narrow-band imaging magnifying observation and pit pattern diagnosis in colorectal tumors. Digestion, 2013; 87: 53-8.

  • Lo P H. Urabe Y. Kumar V. Tanikawa C. Koike K. Kato N. Miki D. Chayama K. Kubo M. Nakamura Y, and Matsuda K, Identification of a functional variant in the MICA promoter which regulates MICA expression and increases HCV-related hepatocellular carcinoma risk. PLoS One, 2013; 8: e61279.

  • Lange C M. Miki D. Ochi H. Nischalke H D. Bojunga J. Bibert S. Morikawa K. Gouttenoire J. Cerny A. Dufour J F. Gorgievski-Hrisoho M. Heim M H. Malinverni R. Mullhaupt B. Negro F. Semela D. Kutalik Z. Muller T. Spengler U. Berg T. Chayama K. Moradpour D. Bochud P Y. Hiroshima Liver Study G, and Swiss Hepatitis C C S G, Genetic analyses reveal a role for vitamin D insufficiency in HCV-associated hepatocellular carcinoma development. PLoS One, 2013; 8: e64053.

  • Mikami S. Nakashima A. Nakagawa K. Maruhashi T. Iwamoto Y. Kajikawa M. Matsumoto T. Kihara Y. Chayama K. Noma K. Ochi M. Nishimura M. Tsuji K. Kato Y. Goto C, and Higashi Y, Autologous bone-marrow mesenchymal stem cell implantation and endothelial function in a rabbit ischemic limb model. PLoS One, 2013; 8: e67739.

  • Hashiba M. Ono M. Hyogo H. Ikeda Y. Masuda K. Yoshioka R. Ishikawa Y. Nagata Y. Munekage K. Ochi T. Hirose A. Nozaki-Fujimura Y. Noguchi S. Okamoto N. Chayama K. Suganuma N, and Saibara T, Glycemic variability is an independent predictive factor for development of hepatic fibrosis in nonalcoholic fatty liver disease. PLoS One, 2013; 8: e76161.

  • Maruhashi T. Nakashima A. Soga J. Fujimura N. Idei N. Mikami S. Iwamoto Y. Kajikawa M. Matsumoto T. Hidaka T. Kihara Y. Chayama K. Goto C. Noma K. Tomiyama H. Takase B. Yamashina A, and Higashi Y, Hyperuricemia is independently associated with endothelial dysfunction in postmenopausal women but not in premenopausal women. BMJ Open, 2013; 3: e003659.

  • Inoue T. Hyodo T. Murakami T. Takayama Y. Nishie A. Higaki A. Korenaga K. Sakamoto A. Osaki Y. Aikata H. Chayama K. Suda T. Takano T. Miyoshi K. Koda M. Numata K. Tanaka H. Iijima H. Ochi H. Hirooka M. Imai Y, and Kudo M, Hypovascular hepatic nodules showing hypointense on the hepatobiliary-phase image of Gd-EOB-DTPA-enhanced MRI to develop a hypervascular hepatocellular carcinoma: a nationwide retrospective study on their natural course and risk factors. Dig Dis, 2013; 31: 472-9.

  • Miki D. Ochi H. Takahashi A. Hayes C N. Urabe Y. Abe H. Kawaoka T. Tsuge M. Hiraga N. Imamura M. Kawakami Y. Aikata H. Takahashi S. Akuta N. Suzuki F. Ikeda K. Kumada H. Karino Y. Toyota J. Tsunoda T. Kubo M. Kamatani N. Nakamura Y, and Chayama K, HLA-DQB1*03 confers susceptibility to chronic hepatitis C in Japanese: a genome-wide association study. PLoS One, 2013; 8: e84226.

  • Sato A. Sata M. Ikeda K. Kumada T. Izumi N. Asahina Y. Osaki Y. Chayama K. Kaneko S. Sakai A. Onji M. Hiasa Y. Omura T. Ozeki I. Yokosuka O. Shiina S. Itsubo M. Nishiguchi S. Hirano K. Ide T. Sakisaka S. Yamasaki T. Hidaka I. Tanaka M. Kim S R, and Ichida T, Clinical characteristics of patients who developed hepatocellular carcinoma after hepatitis C virus eradication with interferon therapy: current status in Japan. Intern Med, 2013; 52: 2701-6.

  • Watari I. Oka S. Tanaka S. Nakano M. Aoyama T. Yoshida S, and Chayama K, Is Occult Obscure Gastrointestinal Bleeding a Definite Indication for Capsule Endoscopy? A Retrospective Analysis of Diagnostic Yield in Patients with Occult versus Overt Bleeding. Gastroenterol Res Pract, 2013; 2013: 915463.

  • Ichikawa K. Fujimori T. Moriya T. Ochiai A. Yoshinaga S. Kushima R. Nagahama R. Ohkura Y. Tanaka S. Ajioka Y. Hirata I. Tanaka M. Hoshihara Y. Kinoshita Y. Sasano H. Iwashita A. Tomita S. Hirota S. Yao T. Fujii S. Matsuda T. Ueno H. Ishikawa Y. Takubo K. Fukushima N. Sugai T. Iwafuchi M. Imura J. Manabe T, and Fukayama M, Digestive disease management in Japan: a report on The 6th Diagnostic Pathology Summer Fest in 2012. Digestion, 2013; 88: 153-60.

  • Fukuhara T. Kakizawa H. Aikata H. Tani C. Ishikawa M. Awai K, and Chayama K, Usefulness of multi-detector row computed tomography for management of duodenal varices by emergency balloon-occluded retrograde transvenous obliteration. Clinical Journal of Gastroenterology, 2013; 6: 243-247.

  • Hyogo H. Yamagishi S-i. Maeda S. Nakahara T. Kimura Y, and Chayama K, sRAGE is associated with low waist circumference and Hb levels in NAFLD. Central European Journal of Medicine, 2013; 8: 830-834.

  • Hirakawa T T T, Raytchev B, Kaneda K, Koide T, Kominami Y, Miyaki R, Matsuo T, Yoshida S, Tanaka S., SMOOTHING POSTERIOR PROBABILITIES WITH A PARTICLE FILTER OF DIRICHLET DISTRIBUTION FOR STABILIZING COLORECTAL NBI ENDOSCOPY RECOGNITION. The proceeding of 2013 IEEE International Conference on Image Processing (ICIP2013) , 2013.

  • Miyaki D. Aikata H. Kan H. Fujino H. Urabe A. Masaki K. Fukuhara T. Kobayashi T. Naeshiro N. Nakahara T. Kawaoka T. Hiramatsu A. Takahashi S. Ishikawa M. Kakizawa H. Awai K, and Chayama K, Clinical outcome of sorafenib treatment in patients with advanced hepatocellular carcinoma refractory to hepatic arterial infusion chemotherapy. J Gastroenterol Hepatol, 2013; 28: 1834-41.

  • Maruhashi T. Soga J. Fujimura N. Idei N. Mikami S. Iwamoto Y. Kajikawa M. Matsumoto T. Hidaka T. Kihara Y. Chayama K. Noma K. Nakashima A. Goto C. Tomiyama H. Takase B. Yamashina A, and Higashi Y, Relationship between flow-mediated vasodilation and cardiovascular risk factors in a large community-based study. Heart, 2013; 99: 1837-42.

  • Onoyama M. Kitadai Y. Tanaka Y. Yuge R. Shinagawa K. Tanaka S. Yasui W, and Chayama K, Combining molecular targeted drugs to inhibit both cancer cells and activated stromal cells in gastric cancer. Neoplasia, 2013; 15: 1391-9.

  • Kosaka K. Hiraga N. Imamura M. Yoshimi S. Murakami E. Nakahara T. Honda Y. Ono A. Kawaoka T. Tsuge M. Abe H. Hayes C N. Miki D. Aikata H. Ochi H. Ishida Y. Tateno C. Yoshizato K. Sasaki T, and Chayama K, A novel TK-NOG based humanized mouse model for the study of HBV and HCV infections. Biochem Biophys Res Commun, 2013; 441: 230-5.

  • Furusho H. Miyauchi M. Hyogo H. Inubushi T. Ao M. Ouhara K. Hisatune J. Kurihara H. Sugai M. Hayes C N. Nakahara T. Aikata H. Takahashi S. Chayama K, and Takata T, Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice. J Gastroenterol, 2013; 48: 1259-70.

  • Masaki K. Takaki S. Hyogo H. Kobayashi T. Fukuhara T. Naeshiro N. Honda Y. Nakahara T. Ohno A. Miyaki D. Murakami E. Nagaoki Y. Kawaoka T. Tsuge M. Hiraga N. Hiramatsu A. Imamura M. Kawakami Y. Aikata H. Ochi H. Takahashi S. Arihiro K, and Chayama K, Utility of controlled attenuation parameter measurement for assessing liver steatosis in Japanese patients with chronic liver diseases. Hepatol Res, 2013; 43: 1182-9.

  • Miwata T. Hiyama T. Oka S. Tanaka S. Shimamoto F. Arihiro K, and Chayama K, Clinicopathologic features of hyperplastic/serrated polyposis syndrome in Japan. J Gastroenterol Hepatol, 2013; 28: 1693-8.

  • Nakai Y. Isayama H. Mukai T. Itoi T. Maetani I. Kawakami H. Yasuda I. Maguchi H. Ryozawa S. Hanada K. Hasebe O. Ito K. Kawamoto H. Mochizuki H. Igarashi Y. Irisawa A. Sasaki T. Togawa O. Hara T. Kamada H. Toda N. Hamada T, and Kogure H, Impact of anticancer treatment on recurrent obstruction in covered metallic stents for malignant biliary obstruction. J Gastroenterol, 2013; 48: 1293-9.

  • Tsuge M. Murakami E. Imamura M. Abe H. Miki D. Hiraga N. Takahashi S. Ochi H. Nelson Hayes C. Ginba H. Matsuyama K. Kawakami H, and Chayama K, Serum HBV RNA and HBeAg are useful markers for the safe discontinuation of nucleotide analogue treatments in chronic hepatitis B patients. J Gastroenterol, 2013; 48: 1188-204.

  • Ishii Y. Sasaki T. Serikawa M. Minami T. Okazaki A. Yukutake M. Ishigaki T. Kosaka K. Mouri T. Yoshimi S. Shimizu A. Tsuboi T, and Chayama K, Elevated expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in primary sclerosing cholangitis: iotamplications for cholangiocarcinogenesis. Int J Oncol, 2013; 43: 1073-9.

  • Numata N. Oka S. Tanaka S. Higashiyama M. Sanomura Y. Yoshida S. Arihiro K, and Chayama K, Clinical outcomes of endoscopic submucosal dissection for early gastric cancer in patients with chronic kidney disease. J Gastroenterol Hepatol, 2013; 28: 1632-7.

  • Hayashi N. Tanaka S. Hewett D G. Kaltenbach T R. Sano Y. Ponchon T. Saunders B P. Rex D K, and Soetikno R M, Endoscopic prediction of deep submucosal invasive carcinoma: validation of the narrow-band imaging international colorectal endoscopic (NICE) classification. Gastrointest Endosc, 2013; 78: 625-32.

  • Abe Y. Aly H H. Hiraga N. Imamura M. Wakita T. Shimotohno K. Chayama K, and Hijikata M, Thromboxane A2 synthase inhibitors prevent production of infectious hepatitis C virus in mice with humanized livers. Gastroenterology, 2013; 145: 658-67 e11.

  • Nakano M. Oka S. Tanaka S. Aoyama T. Watari I. Hayashi R. Miyaki R. Nagai K. Sanomura Y. Yoshida S. Ueno Y, and Chayama K, Clinical usefulness of classification by transabdominal ultrasonography for detection of small-bowel stricture. Scand J Gastroenterol, 2013; 48: 1041-7.

  • Ozawa S. Tanaka S. Hayashi N. Nishiyama S. Terasaki M. Nakadoi K. Kanao H. Oka S. Yoshida S, and Chayama K, Risk factors for vertical incomplete resection in endoscopic submucosal dissection as total excisional biopsy for submucosal invasive colorectal carcinoma. Int J Colorectal Dis, 2013; 28: 1247-56.

  • Yoneda M. Imajo K. Eguchi Y. Fujii H. Sumida Y. Hyogo H. Ono M. Suzuki Y. Kawaguchi T. Aoki N. Sata M. Kanemasa K. Kohgo Y. Saibara T. Chayama K. Itoh Y. Yoshikawa T. Anzai K. Fujimoto K. Okanoue T. Nakajima A, and Japan Study Group of Nonalcoholic Fatty Liver D, Noninvasive scoring systems in patients with nonalcoholic fatty liver disease with normal alanine aminotransferase levels. J Gastroenterol, 2013; 48: 1051-60.

  • Igawa A. Oka S. Tanaka S. Nakano M. Aoyama T. Watari I. Aikata H. Arihiro K, and Chayama K, Small bowel metastasis of hepatocellular carcinoma detected by capsule endoscopy. Case Rep Gastroenterol, 2013; 7: 492-7.

  • Nakajima T. Saito Y. Tanaka S. Iishi H. Kudo S E. Ikematsu H. Igarashi M. Saitoh Y. Inoue Y. Kobayashi K. Hisasbe T. Matsuda T. Ishikawa H, and Sugihara K, Current status of endoscopic resection strategy for large, early colorectal neoplasia in Japan. Surg Endosc, 2013; 27: 3262-70.

  • Imada S. Ishiyama K. Ide K. Kobayashi T. Amano H. Tashiro H. Arihiro K. Aikata H. Chayama K, and Ohdan H, Inferior vena cava tumor thrombus that directly infiltrated from paracaval lymph node metastases in a patient with recurrent hepatocellular carcinoma. World J Surg Oncol, 2013; 11: 177.

  • Idei N. Ukawa T. Kajikawa M. Iwamoto Y. Fujimura N. Maruhashi T. Mikami S. Matsumoto T. Kihara Y. Chayama K. Noma K. Nakashima A. Takayanagi T. Morimoto H. Tsuji T, and Higashi Y, A novel noninvasive and simple method for assessment of endothelial function: enclosed zone flow-mediated vasodilation (ezFMD) using an oscillation amplitude measurement. Atherosclerosis, 2013; 229: 324-30.

  • Watari I. Oka S. Tanaka S. Aoyama T. Imagawa H. Shishido T. Yoshida S, and Chayama K, Effectiveness of polaprezinc for low-dose aspirin-induced small-bowel mucosal injuries as evaluated by capsule endoscopy: a pilot randomized controlled study. BMC Gastroenterol, 2013; 13: 108.

  • Shi N. Hiraga N. Imamura M. Hayes C N. Zhang Y. Kosaka K. Okazaki A. Murakami E. Tsuge M. Abe H. Aikata H. Takahashi S. Ochi H. Tateno-Mukaidani C. Yoshizato K. Matsui H. Kanai A. Inaba T. McPhee F. Gao M, and Chayama K, Combination therapies with NS5A, NS3 and NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice. Gut, 2013; 62: 1055-61.

  • Kitamoto T. Kitamoto A. Yoneda M. Hyogo H. Ochi H. Nakamura T. Teranishi H. Mizusawa S. Ueno T. Chayama K. Nakajima A. Nakao K. Sekine A, and Hotta K, Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan. Hum Genet, 2013; 132: 783-92.

  • Kimura T. Takahashi S. Kenjo M. Nishibuchi I. Takahashi I. Takeuchi Y. Doi Y. Kaneyasu Y. Murakami Y. Honda Y. Aikata H. Chayama K, and Nagata Y, Dynamic computed tomography appearance of tumor response after stereotactic body radiation therapy for hepatocellular carcinoma: How should we evaluate treatment effects? Hepatol Res, 2013; 43: 717-27.

  • Higashimaya M. Oka S. Tanaka S. Sanomura Y. Yoshida S. Hiyama T. Arihiro K. Shimamoto F, and Chayama K, Outcome of endoscopic submucosal dissection for gastric neoplasm in relationship to endoscopic classification of submucosal fibrosis. Gastric Cancer, 2013; 16: 404-10.

  • Nagaoki Y. Aikata H. Kobayashi T. Fukuhara T. Masaki K. Tanaka M. Naeshiro N. Nakahara T. Honda Y. Miyaki D. Kawaoka T. Takaki S. Tsuge M. Hiramatsu A. Imamura M. Hyogo H. Kawakami Y. Takahashi S. Ochi H, and Chayama K, Risk factors for the exacerbation of esophageal varices or portosystemic encephalopathy after sustained virological response with IFN therapy for HCV-related compensated cirrhosis. J Gastroenterol, 2013; 48: 847-55.

  • Yamada A. Watabe H. Oka S. Kogure H. Imagawa H. Kobayashi Y. Suzuki H. Watari I. Aoyama T. Isayama H. Yamaji Y. Fujishiro M. Tanaka S, and Koike K, Feasibility of spiral enteroscopy in Japanese patients: study in two tertiary hospitals. Dig Endosc, 2013; 25: 406-11.

  • Tsuge M and Chayama K, Availability of monitoring serum HBV DNA plus RNA during nucleot(s)ide analogue therapy. J Gastroenterol, 2013; 48: 779-80.

  • Maruhashi T. Soga J. Fujimura N. Idei N. Mikami S. Iwamoto Y. Kajikawa M. Matsumoto T. Hidaka T. Kihara Y. Chayama K. Noma K. Nakashima A. Goto C, and Higashi Y, Nitroglycerine-induced vasodilation for assessment of vascular function: a comparison with flow-mediated vasodilation. Arterioscler Thromb Vasc Biol, 2013; 33: 1401-8.

  • Kuwabara T. Hiyama T. Oka S. Urabe Y. Tanaka S. Yoshihara M. Arihiro K. Shimamoto F, and Chayama K, Response. Gastrointest Endosc, 2013; 77: 973-4.

  • Soetikno R. Subramanian V. Kaltenbach T. Rouse R V. Sanduleanu S. Suzuki N. Tanaka S, and McQuaid K, The detection of nonpolypoid (flat and depressed) colorectal neoplasms in patients with inflammatory bowel disease. Gastroenterology, 2013; 144: 1349-52, 1352 e1-6.

  • Kitamoto A. Kitamoto T. Mizusawa S. Teranishi H. So R. Matsuo T. Nakata Y. Hyogo H. Ochi H. Nakamura T. Kamohara S. Miyatake N. Kotani K. Komatsu R. Itoh N. Mineo I. Wada J. Yoneda M. Nakajima A. Funahashi T. Miyazaki S. Tokunaga K. Masuzaki H. Ueno T. Chayama K. Hamaguchi K. Yamada K. Hanafusa T. Oikawa S. Sakata T. Tanaka K. Matsuzawa Y. Nakao K. Sekine A, and Hotta K, NUDT3 rs206936 is associated with body mass index in obese Japanese women. Endocr J, 2013; 60: 991-1000.

  • Miyaki R. Yoshida S. Tanaka S. Kominami Y. Sanomura Y. Matsuo T. Oka S. Raytchev B. Tamaki T. Koide T. Kaneda K. Yoshihara M, and Chayama K, Quantitative identification of mucosal gastric cancer under magnifying endoscopy with flexible spectral imaging color enhancement. J Gastroenterol Hepatol, 2013; 28: 841-7.

  • Urabe Y. Ochi H. Kato N. Kumar V. Takahashi A. Muroyama R. Hosono N. Otsuka M. Tateishi R. Lo P H. Tanikawa C. Omata M. Koike K. Miki D. Abe H. Kamatani N. Toyota J. Kumada H. Kubo M. Chayama K. Nakamura Y, and Matsuda K, A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region. J Hepatol, 2013; 58: 875-82.

  • Arataki K. Hayes C N. Akamatsu S. Akiyama R. Abe H. Tsuge M. Miki D. Ochi H. Hiraga N. Imamura M. Takahashi S. Aikata H. Kawaoka T. Kawakami H. Ohishi W, and Chayama K, Circulating microRNA-22 correlates with microRNA-122 and represents viral replication and liver injury in patients with chronic hepatitis B. J Med Virol, 2013; 85: 789-98.

  • Oka S. Tanaka S. Nakadoi K. Kanao H, and Chayama K, Risk analysis of submucosal invasive rectal carcinomas for lymph node metastasis to expand indication criteria for endoscopic resection. Dig Endosc, 2013; 25 Suppl 2: 21-5.

  • Aoyama T. Oka S. Aikata H. Nakano M. Watari I. Naeshiro N. Yoshida S. Tanaka S, and Chayama K, Small bowel abnormalities in patients with compensated liver cirrhosis. Dig Dis Sci, 2013; 58: 1390-6.

  • Suenari K. Nakano Y. Hirai Y. Ogi H. Oda N. Makita Y. Ueda S. Kajihara K. Tokuyama T. Motoda C. Fujiwara M. Chayama K, and Kihara Y, Left atrial thickness under the catheter ablation lines in patients with paroxysmal atrial fibrillation: insights from 64-slice multidetector computed tomography. Heart Vessels, 2013; 28: 360-8.

  • Hotta K. Kitamoto A. Kitamoto T. Mizusawa S. Teranishi H. So R. Matsuo T. Nakata Y. Hyogo H. Ochi H. Nakamura T. Kamohara S. Miyatake N. Kotani K. Itoh N. Mineo I. Wada J. Yoneda M. Nakajima A. Funahashi T. Miyazaki S. Tokunaga K. Masuzaki H. Ueno T. Chayama K. Hamaguchi K. Yamada K. Hanafusa T. Oikawa S. Sakata T. Tanaka K. Matsuzawa Y. Nakao K, and Sekine A, Replication study of 15 recently published Loci for body fat distribution in the Japanese population. J Atheroscler Thromb, 2013; 20: 336-50.

  • Hamai Y. Hihara J. Aoki Y. Taomoto J. Kishimoto I. Kobayashi Y. Miyata Y. Aikata H. Chayama K, and Okada M, Airway stenting for tracheal obstruction due to lymph node metastasis of hepatocellular carcinoma. Anticancer Res, 2013; 33: 1761-4.

  • Nakano Y. Chayama K. Ochi H. Toshishige M. Hayashida Y. Miki D. Hayes C N. Suzuki H. Tokuyama T. Oda N. Suenari K. Uchimura-Makita Y. Kajihara K. Sairaku A. Motoda C. Fujiwara M. Watanabe Y. Yoshida Y. Ohkubo K. Watanabe I. Nogami A. Hasegawa K. Watanabe H. Endo N. Aiba T. Shimizu W. Ohno S. Horie M. Arihiro K. Tashiro S. Makita N, and Kihara Y, A nonsynonymous polymorphism in semaphorin 3A as a risk factor for human unexplained cardiac arrest with documented ventricular fibrillation. PLoS Genet, 2013; 9: e1003364.

  • Takata S. Tanaka S. Hayashi N. Terasaki M. Nakadoi K. Kanao H. Oka S. Yoshida S, and Chayama K, Characteristic magnifying narrow-band imaging features of colorectal tumors in each growth type. Int J Colorectal Dis, 2013; 28: 459-68.

  • Suzuki Y. Ikeda K. Suzuki F. Toyota J. Karino Y. Chayama K. Kawakami Y. Ishikawa H. Watanabe H. Hu W. Eley T. McPhee F. Hughes E, and Kumada H, Dual oral therapy with daclatasvir and asunaprevir for patients with HCV genotype 1b infection and limited treatment options. J Hepatol, 2013; 58: 655-62.

  • Karino Y. Toyota J. Ikeda K. Suzuki F. Chayama K. Kawakami Y. Ishikawa H. Watanabe H. Hernandez D. Yu F. McPhee F, and Kumada H, Characterization of virologic escape in hepatitis C virus genotype 1b patients treated with the direct-acting antivirals daclatasvir and asunaprevir. J Hepatol, 2013; 58: 646-54.

  • Chayama K. Hayes C N. Ohishi W, and Kawakami Y, Response to "treatment guidelines for HCV genotype 1: mono for low, triple for high, and dual for 'middle'?". J Gastroenterol, 2013; 48: 557-8.

  • Okuyama Y. Andoh A. Nishishita M. Fukunaga K. Kamikozuru K. Yokoyama Y. Ueno Y. Tanaka S. Kuge H. Yoshikawa S. Sugahara A. Anami E. Munetomo Y. Watanabe C. Fujiyama Y, and Matsumoto T, Multicenter prospective study for clinical and endoscopic efficacies of leukocytapheresis therapy in patients with ulcerative colitis. Scand J Gastroenterol, 2013; 48: 412-8.

  • Quach D T. Le H M. Hiyama T. Nguyen O T. Nguyen T S, and Uemura N, Relationship between endoscopic and histologic gastric atrophy and intestinal metaplasia. Helicobacter, 2013; 18: 151-7.

  • Tari A. Asaoku H. Kunihiro M. Tanaka S, and Yoshino T, Usefulness of positron emission tomography in primary intestinal follicular lymphoma. World J Gastroenterol, 2013; 19: 1992-6.

  • Fujii Y. Teragawa H. Soga J. Idei N. Fujimura N. Maruhashi T. Mikami S. Iwamoto Y. Hidaka T. Kihara Y. Chayama K. Noma K. Nakashima A. Goto C, and Higashi Y, Flow-mediated vasodilation and anatomical variation of the brachial artery (double brachial artery) in healthy subjects and patients with cardiovascular disease. Circ J, 2013; 77: 1073-80.

  • Asayama N. Ikehara H. Yano H, and Saito Y, Endoscopic submucosal dissection of multiple flat adenomas in the radiated rectum. World J Gastrointest Endosc, 2013; 5: 128-31.

  • Toyota J. Ozeki I. Karino Y. Asahina Y. Izumi N. Takahashi S. Kawakami Y. Chayama K. Kamiya N. Aoki K. Yamada I. Suzuki Y. Suzuki F, and Kumada H, Virological response and safety of 24-week telaprevir alone in Japanese patients infected with hepatitis C virus subtype 1b. J Viral Hepat, 2013; 20: 167-73.

  • Honda Y. Kimura T. Aikata H. Kobayashi T. Fukuhara T. Masaki K. Nakahara T. Naeshiro N. Ono A. Miyaki D. Nagaoki Y. Kawaoka T. Takaki S. Hiramatsu A. Ishikawa M. Kakizawa H. Kenjo M. Takahashi S. Awai K. Nagata Y, and Chayama K, Stereotactic body radiation therapy combined with transcatheter arterial chemoembolization for small hepatocellular carcinoma. J Gastroenterol Hepatol, 2013; 28: 530-6.

  • Zhang Y. Takahashi S. Tasaka A. Yoshima T. Ochi H, and Chayama K, Involvement of microRNA-224 in cell proliferation, migration, invasion, and anti-apoptosis in hepatocellular carcinoma. J Gastroenterol Hepatol, 2013; 28: 565-75.

  • Tashiro H. Ide K. Amano H. Kobayashi T. Onoe T. Ishiyama K. Kuroda S. Tazawa H. Kono H. Aikata H. Takahashi S. Chayama K, and Ohdan H, Surgical treatment for portosystemic encephalopathy in patients with liver cirrhosis: Occlusion of portosystemic shunt in combination with splenectomy. Hepatol Res, 2013; 43: 249-54.

  • Tanaka S. Terasaki M. Hayashi N. Oka S, and Chayama K, Warning for unprincipled colorectal endoscopic submucosal dissection: accurate diagnosis and reasonable treatment strategy. Dig Endosc, 2013; 25: 107-16.

  • Takamura A. Ito M. Boda T. Matsumoto Y. Tanaka S. Yoshihara M, and Chayama K, High expression of gastrin receptor protein in injured mucosa of Helicobacter pylori-positive gastritis. Dig Dis Sci, 2013; 58: 634-40.

  • Izumi N. Asahina Y. Kurosaki M. Yamada G. Kawai T. Kajiwara E. Okamura Y. Takeuchi T. Yokosuka O. Kariyama K. Toyoda J. Inao M. Tanaka E. Moriwaki H. Adachi H. Katsushima S. Kudo M. Takaguchi K. Hiasa Y. Chayama K. Yatsuhashi H. Oketani M, and Kumada H, Inhibition of hepatocellular carcinoma by PegIFNalpha-2a in patients with chronic hepatitis C: a nationwide multicenter cooperative study. J Gastroenterol, 2013; 48: 382-90.

  • Tanaka S. Hayashi N. Oka S, and Chayama K, Endoscopic assessment of colorectal cancer with superficial or deep submucosal invasion using magnifying colonoscopy. Clin Endosc, 2013; 46: 138-46.

  • Miwa H. Takubo K. Shimatani T. Furuta T. Oshima T. Tanaka J. Aida J. Ito M. Kurosawa S. Joh T. Wada T. Habu Y. Watanabe Y. Hongo M. Chiba T. Kinoshita Y, and Aid-Related Symptom Research G, Histology of symptomatic gastroesophageal reflux disease: is it predictive of response to proton pump inhibitors? J Gastroenterol Hepatol, 2013; 28: 479-87.

  • Uraoka T. Tanaka S. Matsumoto T. Matsuda T. Oka S. Moriyama T. Higashi R, and Saito Y, A novel extra-wide-angle-view colonoscope: a simulated pilot study using anatomic colorectal models. Gastrointest Endosc, 2013; 77: 480-3.

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