業績紹介

Achivement

2010年業績

• Akuta N, Suzuki F, Hirakawa M, Kawamura Y, Yatsuji H, Sezaki H, Suzuki Y, Hosaka T, Kobayashi M, Kobayashi M, Saitoh S, Arase Y, Ikeda K, Chayama K, Nakamura Y and Kumada H.

  Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin.

  Hepatology. 2010; 52: 421-429.

• Hotta K, Yoneda M, Hyogo H, Ochi H, Mizusawa S, Ueno T, Chayama K, Nakajima A, Nakao K and Sekine A.

  Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease.

  BMC Med Genet. 2010; 11: 172

• Katamura Y, Aikata H, Hashimoto Y, Kimura Y, Kawaoka T, Takaki S, Waki K, Hiramatsu A, Kawakami Y, Takahashi S, Kenjo M and Chayama K.

  Zoledronic acid delays disease progression of bone metastases from hepatocellular carcinoma.

  Hepatol Res. 2010; 40: 1195-1203.

• Chayama K, Hayes CN, Yoshioka K, Moriwaki H, Okanoue T, Sakisaka S, Takehara T, Oketani M, Toyota J, Izumi N, Hiasa Y, Matsumoto A, Nomura H, Seike M, Ueno Y, Yotsuyanagi H and Kumada H.

  Accumulation of refractory factors for pegylated interferon plus ribavirin therapy in older female patients with chronic hepatitis C.

  Hepatol Res. 2010; 40: 1155-1167.

• Imagawa S, Ito M, Yoshihara M, Eguchi H, Tanaka S and Chayama K.

  Helicobacter pylori dupA and gastric acid secretion are negatively associated with gastric cancer development.

  J Med Microbiol. 2010; 59: 1484-1489.

• Sanomura Y, Oka S, Tanaka S, Higashiyama M, Yoshida S, Arihiro K, Shimamoto F and Chayama K.

  Predicting the absence of lymph node metastasis of submucosal invasive gastric cancer: expansion of the criteria for curative endoscopic resection.

  Scand J Gastroenterol. 2010; 45: 1480-1487.

• Kawaoka T, Hiraga N, Takahashi S, Takaki S, Mitsui F, Tsuge M, Nagaoki Y, Kimura Y, Hashimoto Y, Katamura Y, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Aikata H, Tashiro H, Ohdan H and Chayama K.

  Prolongation of interferon therapy for recurrent hepatitis C after living donor liver transplantation: analysis of predictive factors of sustained virological response, including amino acid sequence of the core and NS5A regions of hepatitis C virus.

  Scand J Gastroenterol. 2010; 45: 1488-1496.

• Suda G, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Funaoka Y, Watanabe T, Nitta S, Kiyohashi K, Azuma S, Kakinuma S, Tsuchiya K, Imamura M, Hiraga N, Chayama K and Watanabe M.

  IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones.

  Virology. 2010; 407: 80-90.

• Sakano A, Yanai H, Sakaguchi E, Tanioka Y, Yahara N, Hayashi H, Murakami T and Chayama K.

  Clinical impact of tumor invasion depth staging of esophageal squamous cell carcinoma using endoscopic ultrasonography.

  Hepatogastroenterology. 2010; 57: 1423-1429.

• Takemura Y, Yoshida S, Tanaka S, Onji K, Oka S, Tamaki T, Kaneda K, Yoshihara M and Chayama K.

  Quantitative analysis and development of a computer-aided system for identification of regular pit patterns of colorectal lesions.

  Gastrointest Endosc. 2010; 72: 1047-1051.

• Kawaoka T, Aikata H, Takaki S, Hashimoto Y, Katamura Y, Hiramatsu A, Waki K, Takahashi S, Kamada K, Kitamoto M, Nakanishi T, Ishikawa M, Hieda M, Kakizawa H, Tanaka J and Chayama K.

  Transcatheter chemoembolization for unresectable hepatocellular carcinoma and comparison of five staging systems.

  Hepatol Res. 2010; 40: 1082-1091.

• Matsumoto A, Tanaka S, Oba S, Kanao H, Oka S, Yoshihara M and Chayama K.

  Outcome of endoscopic submucosal dissection for colorectal tumors accompanied by fibrosis.

  Scand J Gastroenterol. 2010; 45: 1329-1337.

• Kodama H, Aikata H, Takaki S, Azakami T, Katamura Y, Kawaoka T, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Takahashi S, Toyota N, Ito K and Chayama K.

  Evaluation of portosystemic collaterals by MDCT-MPR imaging for management of hemorrhagic esophageal varices.

  Eur J Radiol. 2010; 76: 239-245.

• Ochi H, Maekawa T, Abe H, Hayashida Y, Nakano R, Kubo M, Tsunoda T, Hayes CN, Kumada H, Nakamura Y and Chayama K.

  ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy--a genome-wide study of Japanese HCV virus patients.

  Gastroenterology. 2010; 139: 1190-1197.

• Tanaka M, Kitadai Y, Kodama M, Shinagawa K, Sumida T, Tanaka S, Oue N, Yasui W and Chayama K.

  Potential role for vascular endothelial growth factor-D as an autocrine factor for human gastric carcinoma cells.

  Cancer Sci. 2010; 101: 2121-2127.

• Miki D, Kubo M, Takahashi A, Yoon KA, Kim J, Lee GK, Zo JI, Lee JS, Hosono N, Morizono T, Tsunoda T, Kamatani N, Chayama K, Takahashi T, Inazawa J, Nakamura Y and Daigo Y.

  Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations.

  Nat Genet. 2010; 42: 893-896.

• Mishima K, Sakamoto N, Sekine-Osajima Y, Nakagawa M, Itsui Y, Azuma S, Kakinuma S, Kiyohashi K, Kitazume A, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Wakita T and Watanabe M.

  Cell culture and in vivo analyses of cytopathic hepatitis C virus mutants.

  Virology. 2010; 405: 361-369.

• Katamura Y, Aikata H, Hashimoto Y, Kimura Y, Kawaoka T, Takaki S, Waki K, Hiramatsu A, Kawakami Y, Takahashi S and Chayama K.

  Pilot study of systemic combination therapy with S-1, an oral fluoropyrimidine, and cisplatin for hepatocellular carcinoma with extrahepatic metastases.

  Hepatogastroenterology. 2010; 57: 1272-1278.

• Kodama M, Kitadai Y, Sumida T, Ohnishi M, Ohara E, Tanaka M, Shinagawa K, Tanaka S, Yasui W and Chayama K.

  Expression of platelet-derived growth factor (PDGF)-B and PDGF-receptor beta is associated with lymphatic metastasis in human gastric carcinoma.

  Cancer Sci. 2010; 101: 1984-1989.

• Abe H, Ochi H, Maekawa T, Hayes CN, Tsuge M, Miki D, Mitsui F, Hiraga N, Imamura M, Takahashi S, Ohishi W, Arihiro K, Kubo M, Nakamura Y and Chayama K.

  Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients.

  J Hepatol. 2010; 53: 439-443.

• Okita K, Sakaida I, Okada M, Kaneko A, Chayama K, Kato M, Sata M, Yoshihara H, Ono N and Murawaki Y.

  A multicenter, open-label, dose-ranging study to exploratively evaluate the efficacy, safety, and dose-response of tolvaptan in patients with decompensated liver cirrhosis.

  J Gastroenterol. 2010; 45: 979-987.

• Oba S, Tanaka S, Oka S, Kanao H, Yoshida S, Shimamoto F and Chayama K.

  Characterization of colorectal tumors using narrow-band imaging magnification: combined diagnosis with both pit pattern and microvessel features.

  Scand J Gastroenterol. 2010; 45: 1084-1092.

• Kawaoka T, Aikata H, Katamura Y, Takaki S, Waki K, Hiramatsu A, Takahashi S, Hieda M, Kakizawa H and Chayama K.

  Hypersensitivity reactions to transcatheter chemoembolization with cisplatin and Lipiodol suspension for unresectable hepatocellular carcinoma.

  J Vasc Interv Radiol. 2010; 21: 1219-1225.

• Mitsui F, Tsuge M, Kimura T, Kitamura S, Abe H, Saneto H, Kawaoka T, Miki D, Hatakeyama T, Hiraga N, Imamura M, Kawakami Y, Aikata H, Takahashi S, Hayes CN, Igarashi H, Morimoto K, Shimizu M and Chayama K.

  Importance of serum concentration of adefovir for Lamivudine-adefovir combination therapy in patients with lamivudine-resistant chronic hepatitis B.

  Antimicrob Agents Chemother. 2010; 54: 3205-3211.

• Waki K, Anno K, Ono T, Ide T, Chayama K and Tahara H.

  Establishment of functional telomerase immortalized human hepatocytes and a hepatic stellate cell line for telomere-targeting anticancer drug development.

  Cancer Sci. 2010; 101: 1678-1685.

• Tsuge M, Hiraga N, Akiyama R, Tanaka S, Matsushita M, Mitsui F, Abe H, Kitamura S, Hatakeyama T, Kimura T, Miki D, Mori N, Imamura M, Takahashi S, Hayes CN and Chayama K.

  HBx protein is indispensable for development of viraemia in human hepatocyte chimeric mice.

  J Gen Virol. 2010; 91: 1854-1864.

• Kamiya N, Iwao E, Hiraga N, Tsuge M, Imamura M, Takahashi S, Miyoshi S, Tateno C, Yoshizato K and Chayama K.

  Practical evaluation of a mouse with chimeric human liver model for hepatitis C virus infection using an NS3-4A protease inhibitor.

  J Gen Virol. 2010; 91: 1668-1677.

• Kimura Y, Hyogo H, Yamagishi S, Takeuchi M, Ishitobi T, Nabeshima Y, Arihiro K and Chayama K.

  Atorvastatin decreases serum levels of advanced glycation endproducts (AGEs) in nonalcoholic steatohepatitis (NASH) patients with dyslipidemia: clinical usefulness of AGEs as a biomarker for the attenuation of NASH.

  J Gastroenterol. 2010; 45: 750-757.

• Ueno Y, Tanaka S and Chayama K.

  Non-polypoid colorectal neoplasms in ulcerative colitis.

  Gastrointest Endosc Clin N Am. 2010; 20: 525-542.

• Yokosuka O, Takaguchi K, Fujioka S, Shindo M, Chayama K, Kobashi H, Hayashi N, Sato C, Kiyosawa K, Tanikawa K, Ishikawa H, Masaki N, Seriu T and Omata M.

  Long-term use of entecavir in nucleoside-naive Japanese patients with chronic hepatitis B infection.

  J Hepatol. 2010; 52: 791-799.

• Katamura Y, Aikata H, Kimura Y, Kawaoka T, Takaki S, Waki K, Hiramatsu A, Kawakami Y, Takahashi S, Ishikawa M, Hieda M, Kakizawa H and Chayama K.

  Intra-arterial 5-fluorouracil/interferon combination therapy for hepatocellular carcinoma with portal vein tumor thrombosis and extrahepatic metastases.

  J Gastroenterol Hepatol. 2010; 25: 1117-1122.

• Tsuge M, Noguchi C, Akiyama R, Matsushita M, Kunihiro K, Tanaka S, Abe H, Mitsui F, Kitamura S, Hatakeyama T, Kimura T, Miki D, Hiraga N, Imamura M, Takahashi S, Hayses CN and Chayama K.

  G to A hypermutation of TT virus.

  Virus Res. 2010; 149: 211-216.

• Waki K, Aikata H, Katamura Y, Kawaoka T, Takaki S, Hiramatsu A, Takahashi S, Toyota N, Ito K and Chayama K.

  Percutaneous radiofrequency ablation as first-line treatment for small hepatocellular carcinoma: results and prognostic factors on long-term follow up.

  J Gastroenterol Hepatol. 2010; 25: 597-604.

• Fukuhara T, Hiyama T, Tanaka S, Oka S, Yoshihara M, Arihiro K and Chayama K.

  Characteristics of esophageal squamous cell carcinomas and lugol-voiding lesions in patients with head and neck squamous cell carcinoma.

  J Clin Gastroenterol. 2010; 44: e27-33.

• Kumada H, Okanoue T, Onji M, Moriwaki H, Izumi N, Tanaka E, Chayama K, Sakisaka S, Takehara T, Oketani M, Suzuki F, Toyota J, Nomura H, Yoshioka K, Seike M, Yotsuyanagi H, Ueno Y, Study Group for the Standardization of Treatment of Viral Hepatitis Including Cirrhosis MoHL and Welfare of J.

  Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis C virus infection for the fiscal year 2008 in Japan.

  Hepatol Res. 2010; 40: 8-13.

• Kumada H, Okanoue T, Onji M, Moriwaki H, Izumi N, Tanaka E, Chayama K, Sakisaka S, Takehara T, Oketani M, Suzuki F, Toyota J, Nomura H, Yoshioka K, Seike M, Yotsuyanagi H, Ueno Y, Study Group for the Standardization of Treatment of Viral Hepatitis Including Cirrhosis MoHL and Welfare of J.

  Guidelines for the treatment of chronic hepatitis and cirrhosis due to hepatitis B virus infection for the fiscal year 2008 in Japan.

  Hepatol Res. 2010; 40: 1-7.

• Shimomura T, Hiyama T, Tanaka S, Yoshihara M, Arihiro K and Chayama K.

  Synchronous and subsequent lesions of serrated adenomas and tubular adenomas of the colorectum.

  Pathobiology. 2010; 77: 273-277.

• Ide T, Sata M, Chayama K, Shindo M, Toyota J, Mochida S, Tomita E, Kumada H, Yamada G, Yatsuhashi H, Hayashi N, Ishikawa H, Seriu T and Omata M.

  Evaluation of long-term entecavir treatment in stable chronic hepatitis B patients switched from lamivudine therapy.

  Hepatol Int. 2010; 4: 594-600.

• Huang YW, Chayama K, Tsuge M, Takahashi S, Hatakeyama T, Abe H, Hu JT, Liu CJ, Lai MY, Chen DS, Yang SS and Kao JH.

  Differential effects of interferon and lamivudine on serum HBV RNA inhibition in patients with chronic hepatitis B.

  Antivir Ther. 2010; 15: 177-184.

• Fukuhara T, Hiyama T, Tanaka S, Oka S, Yoshihara M, Arihiro K and Chayama K.

  Natural course of lugol-voiding lesions in patients with superficial esophageal squamous cell carcinoma.

  Digestion. 2010; 82: 60-65.

• Wada Y, Ito M, Takata S, Tanaka S, Yoshihara M and Chayama K.

  Relationship between Helicobacter pylori tyrosine-phosphorylated CagA-related markers and the development of diffuse-type gastric cancers: a case-control study.

  Digestion. 2010; 82: 10-17.

• Noda I, Kitamoto M, Nakahara H, Hayashi R, Okimoto T, Monzen Y, Yamada H, Imagawa M, Hiraga N, Tanaka J and Chayama K.

  Regular surveillance by imaging for early detection and better prognosis of hepatocellular carcinoma in patients infected with hepatitis C virus.

  J Gastroenterol. 2010; 45: 105-112.

• Kitamura S, Tsuge M, Hatakeyama T, Abe H, Imamura M, Mori N, Saneto H, Kawaoka T, Mitsui F, Hiraga N, Takaki S, Kawakami Y, Aikata H, Takahashi S, Ohishi W, Ochi H, Hayes CN and Chayama K.

  Amino acid substitutions in core and NS5A regions of the HCV genome can predict virological decrease with pegylated interferon plus ribavirin therapy.

  Antivir Ther. 2010; 15: 1087-1097.

• Yoshioka K, Ueno Y, Tanaka S, Nagai K, Onitake T, Hanaoka R and Chayama K.

  Efficacy of ecabet sodium enema on intractable rectal ulcer after piecemeal endoscopic mucosal resection for rectal tumor.

  Clinical Journal of Gastroenterology. 2010; 3: 285-288.