業績紹介

Achivement

2016年業績

• Leong CR, Funami K, Oshiumi H, Mengao D, Takaki H, Matsumoto M, Aly HH, Watashi K, Chayama K and Seya T.

  Interferon-stimulated gene of 20 kDa protein (ISG20) degrades RNA of Hepatitis B virus to impede the replication of HBV in vitro and in vivo.

  Oncotarget. 2016; 7: 68179-68193.

• DebRoy S, Hiraga N, Imamura M, Hayes CN, Akamatsu S, Canini L, Perelson AS, Pohl RT, Persiani S, Uprichard SL, Tateno C, Dahari H and Chayama K.

  Hepatitis C virus dynamics and cellular gene expression in uPA-SCID chimeric mice with humanized livers during intravenous silibinin monotherapy.

  J Viral Hepat. 2016; 23: 708-717.

• Miwata T, Oka S, Tanaka S, Kagemoto K, Sanomura Y, Urabe Y, Hiyama T and Chayama K.

  Risk factors for esophageal stenosis after entire circumferential endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma.

  Surg Endosc. 2016; 30: 4049-4056.

• Ninomiya Y, Oka S, Tanaka S, Hirano D, Sumimoto K, Tamaru Y, Asayama N, Shigita K, Nishiyama S, Hayashi N and Chayama K.

  Clinical impact of dual red imaging in colorectal endoscopic submucosal dissection: a pilot study.

  Therap Adv Gastroenterol. 2016; 9: 679-683.

• Honda Y, Yoneda M, Kessoku T, Ogawa Y, Tomeno W, Imajo K, Mawatari H, Fujita K, Hyogo H, Ueno T, Chayama K, Saito S, Nakajima A and Hotta K.

  Characteristics of non-obese non-alcoholic fatty liver disease: Effect of genetic and environmental factors.

  Hepatol Res. 2016; 46: 1011-1018.

• Kumagai E, Mano Y, Yoshio S, Shoji H, Sugiyama M, Korenaga M, Ishida T, Arai T, Itokawa N, Atsukawa M, Hyogo H, Chayama K, Ohashi T, Ito K, Yoneda M, Kawaguchi T, Torimura T, Nozaki Y, Watanabe S, Mizokami M and Kanto T.

  Serum YKL-40 as a marker of liver fibrosis in patients with non-alcoholic fatty liver disease.

  Sci Rep. 2016; 6: 35282.

• Yoshifuku Y, Oka S, Tanaka S, Sanomura Y, Miwata T, Numata N, Hiyama T and Chayama K.

  Long-term prognosis after endoscopic submucosal dissection for early gastric cancer in super-elderly patients.

  Surg Endosc. 2016; 30: 4321-4329.

• Tamaru Y, Oka S, Tanaka S, Hiraga Y, Kunihiro M, Nagata S, Furudoi A, Ninomiya Y, Asayama N, Shigita K, Nishiyama S, Hayashi N and Chayama K.

  Endoscopic submucosal dissection for anorectal tumor with hemorrhoids close to the dentate line: a multicenter study of Hiroshima GI Endoscopy Study Group.

  Surg Endosc. 2016; 30: 4425-4431.

• Kumada H, Mochida S, Suzuki F, Chayama K, Karino Y, Nakamura K, Fujimoto G, Howe AY, Ludmerer SW and Mobashery N.

  Vaniprevir plus peginterferon alfa-2b and ribavirin in treatment-experienced Japanese patients with hepatitis C virus genotype 1 (GT1b) infection: Phase 3 studies.

  J Gastroenterol Hepatol. 2016; 31: 1674-1683.

• Abe-Chayama H, Hayes CN and Chayama K.

  Pan-genotypic cell culture system for propagation of hepatitis C virus clinical isolates.

  Hepatology. 2016; 64: 1356-1358.

• Yoshifuku Y, Sanomura Y, Oka S, Tanaka S and Chayama K.

  Investigation of each histological type in undifferentiated early gastric cancer and validity of diagnosis of the disease range.

  Gastric Cancer. 2016; 19: 1149-1150.

• Mouri T, Sasaki T, Serikawa M, Ishigaki T, Ishii Y, Shimizu A, Tsuboi T, Kurihara K, Tatsukawa Y, Miyaki E, Kawamura R, Tsushima K and Chayama K.

  A comparison of 4-Fr with 5-Fr endoscopic nasopancreatic drainage catheters: A randomized, controlled trial.

  J Gastroenterol Hepatol. 2016; 31: 1783-1789.

• Tsuge M, Hiraga N, Uchida T, Kan H, Miyaki E, Masaki K, Ono A, Nakahara T, Abe-Chayama H, Zhang Y, Naswa MG, Kawaoka T, Miki D, Imamura M, Kawakami Y, Aikata H, Ochi H, Hayes CN and Chayama K.

  Antiviral effects of anti-HBs immunoglobulin and vaccine on HBs antigen seroclearance for chronic hepatitis B infection.

  J Gastroenterol. 2016; 51: 1073-1080.

• Sakuma T, Masaki K, Abe-Chayama H, Mochida K, Yamamoto T and Chayama K.

  Highly multiplexed CRISPR-Cas9-nuclease and Cas9-nickase vectors for inactivation of hepatitis B virus.

  Genes Cells. 2016; 21: 1253-1262.

• Igawa A, Oka S, Tanaka S and Chayama K.

  Response.

  Gastrointest Endosc. 2016; 84: 875.

• Kawakami Y, Imamura M, Ikeda H, Suzuki M, Arataki K, Moriishi M, Mori N, Kokoroishi K, Katamura Y, Ezaki T, Ueno T, Ide K, Masaki T, Ohdan H and Chayama K.

  Pharmacokinetics, efficacy and safety of daclatasvir plus asunaprevir in dialysis patients with chronic hepatitis C: pilot study.

  J Viral Hepat. 2016; 23: 850-856.

• Nishiyama S, Oka S, Tanaka S, Sagami S, Hayashi R, Ueno Y, Arihiro K and Chayama K.

  Clinical usefulness of narrow band imaging magnifying colonoscopy for assessing ulcerative colitis-associated cancer/dysplasia.

  Endosc Int Open. 2016; 4: E1183-E1187.

• Morio K, Imamura M, Kawakami Y, Morio R, Hatooka M, Kan H, Fujino H, Fukuhara T, Kobayashi T, Masaki K, Ono A, Nakahara T, Urabe A, Yokoyama S, Nagaoki Y, Kawaoka T, Hiraga N, Tsuge M, Hiramatsu A, Hayes CN, Aikata H, Ochi H, Chayama K and Hiroshima Liver Study G.

  Effects of ITPA polymorphism on decrease of hemoglobin during simeprevir, peg-interferon, and ribavirin combination treatment for chronic hepatitis C.

  Hepatol Res. 2016; 46: 1256-1263.

• Aizawa S, Okamoto T, Sugiyama Y, Kouwaki T, Ito A, Suzuki T, Ono C, Fukuhara T, Yamamoto M, Okochi M, Hiraga N, Imamura M, Chayama K, Suzuki R, Shoji I, Moriishi K, Moriya K, Koike K and Matsuura Y.

  TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis.

  Nat Commun. 2016; 7: 11379.

• Hayashi R, Tsuchiya K, Fukushima K, Horita N, Hibiya S, Kitagaki K, Negi M, Itoh E, Akashi T, Eishi Y, Okada E, Araki A, Ohtsuka K, Fukuda S, Ohno H, Okamoto R, Nakamura T, Tanaka S, Chayama K and Watanabe M.

  Reduced Human alpha-defensin 6 in Noninflamed Jejunal Tissue of Patients with Crohn's Disease.

  Inflamm Bowel Dis. 2016; 22: 1119-1128.

• Yamamoto S, Fukuhara T, Ono C, Uemura K, Kawachi Y, Shiokawa M, Mori H, Wada M, Shima R, Okamoto T, Hiraga N, Suzuki R, Chayama K, Wakita T and Matsuura Y.

  Lipoprotein Receptors Redundantly Participate in Entry of Hepatitis C Virus.

  PLoS Pathog. 2016; 12: e1005610.

• Fujimoto A, Furuta M, Totoki Y, Tsunoda T, Kato M, Shiraishi Y, Tanaka H, Taniguchi H, Kawakami Y, Ueno M, Gotoh K, Ariizumi S, Wardell CP, Hayami S, Nakamura T, Aikata H, Arihiro K, Boroevich KA, Abe T, Nakano K, Maejima K, Sasaki-Oku A, Ohsawa A, Shibuya T, Nakamura H, Hama N, Hosoda F, Arai Y, Ohashi S, Urushidate T, Nagae G, Yamamoto S, Ueda H, Tatsuno K, Ojima H, Hiraoka N, Okusaka T, Kubo M, Marubashi S, Yamada T, Hirano S, Yamamoto M, Ohdan H, Shimada K, Ishikawa O, Yamaue H, Chayama K, Miyano S, Aburatani H, Shibata T and Nakagawa H.

  Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer.

  Nat Genet. 2016; 48: 500-509.

• Shigita K, Oka S, Tanaka S, Sumimoto K, Hirano D, Tamaru Y, Ninomiya Y, Asayama N, Hayashi N, Nagata S, Arihiro K and Chayama K.

  Clinical significance and validity of the subclassification for colorectal laterally spreading tumor granular type.

  J Gastroenterol Hepatol. 2016; 31: 973-979.

• Nagaoki Y, Aikata H, Nakano N, Shinohara F, Nakamura Y, Hatooka M, Morio K, Kan H, Fujino H, Kobayashi T, Fukuhara T, Masaki K, Ono A, Nakahara T, Kawaoka T, Miki D, Tsuge M, Hiramatsu A, Imamura M, Takahashi S, Kawakami Y, Ochi H, Chayama K and Hiroshima Liver Study G.

  Development of hepatocellular carcinoma in patients with hepatitis C virus infection who achieved sustained virological response following interferon therapy: A large-scale, long-term cohort study.

  J Gastroenterol Hepatol. 2016; 31: 1009-1015.

• Kawaguchi Y, Hinoi T, Saito Y, Adachi T, Miguchi M, Niitsu H, Sasada T, Shimomura M, Egi H, Oka S, Tanaka S, Chayama K, Sentani K, Oue N, Yasui W and Ohdan H.

  Mouse model of proximal colon-specific tumorigenesis driven by microsatellite instability-induced Cre-mediated inactivation of Apc and activation of Kras.

  J Gastroenterol. 2016; 51: 447-457.

• Kitamoto A, Kitamoto T, Nakamura T, Matsuo T, Nakata Y, Hyogo H, Ochi H, Kamohara S, Miyatake N, Kotani K, Mineo I, Wada J, Ogawa Y, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Masuzaki H, Ueno T, Chayama K, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Sakata T, Tanaka K, Matsuzawa Y and Hotta K.

  CDH13 Polymorphisms are Associated with Adiponectin Levels and Metabolic Syndrome Traits Independently of Visceral Fat Mass.

  J Atheroscler Thromb. 2016; 23: 309-319.

• Nakano M, Oka S, Tanaka S, Kunihara S, Igawa A, Aoyama T, Imagawa H, Onogawa S, Ueno Y, Hanada K and Chayama K.

  Clinical usefulness of transabdominal ultrasonography prior to patency capsule for suspected small-bowel strictures.

  Scand J Gastroenterol. 2016; 51: 281-287.

• Yamamoto N, Sato Y, Munakata T, Kakuni M, Tateno C, Sanada T, Hirata Y, Murakami S, Tanaka Y, Chayama K, Hatakeyama H, Hyodo M, Harashima H and Kohara M.

  Novel pH-sensitive multifunctional envelope-type nanodevice for siRNA-based treatments for chronic HBV infection.

  J Hepatol. 2016; 64: 547-555.

• Kominami Y, Yoshida S, Tanaka S, Sanomura Y, Hirakawa T, Raytchev B, Tamaki T, Koide T, Kaneda K and Chayama K.

  Computer-aided diagnosis of colorectal polyp histology by using a real-time image recognition system and narrow-band imaging magnifying colonoscopy.

  Gastrointest Endosc. 2016; 83: 643-649.

• Asayama N, Oka S, Tanaka S, Ninomiya Y, Tamaru Y, Shigita K, Hayashi N, Egi H, Hinoi T, Ohdan H, Arihiro K and Chayama K.

  Long-term outcomes after treatment for T1 colorectal carcinoma.

  Int J Colorectal Dis. 2016; 31: 571-578.

• Kan H, Hyogo H, Ochi H, Hotta K, Fukuhara T, Kobayashi T, Naeshiro N, Honda Y, Kawaoka T, Tsuge M, Hiramatsu A, Imamura M, Kawakami Y, Aikata H and Chayama K.

  Influence of the rs738409 polymorphism in patatin-like phospholipase 3 on the treatment efficacy of non-alcoholic fatty liver disease with type 2 diabetes mellitus.

  Hepatol Res. 2016; 46: E146-153.

• Omura Y, Kitamoto M, Hyogo H, Yamanoue T, Tada Y, Boku N, Nishisaka T, Miyauchi M, Takata T and Chayama K.

  Morbidly obese patient with non-alcoholic steatohepatitis-related cirrhosis who died from sepsis caused by dental infection of Porphyromonas gingivalis: A case report.

  Hepatol Res. 2016; 46: E210-215.

• Yoshimatsu R, Yamagami T, Ishikawa M, Kajiwara K, Aikata H, Chayama K and Awai K.

  Change in Imaging Findings on Angiography-Assisted CT During Balloon-Occluded Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma.

  Cardiovasc Intervent Radiol. 2016; 39: 865-874.

• Tokushige K, Hyogo H, Nakajima T, Ono M, Kawaguchi T, Honda K, Eguchi Y, Nozaki Y, Kawanaka M, Tanaka S, Imajo K, Sumida Y, Kamada Y, Fujii H, Suzuki Y, Kogiso T, Karino Y, Munekage K, Kuromatsu R, Oeda S, Yanase M, Mori K, Ogawa Y, Seko Y, Takehara T, Itoh Y, Nakajima A, Kanemasa K, Nishino K, Masaki N, Takahashi H, Seike M, Torimura T, Saibara T, Toyota J, Chayama K and Hashimoto E.

  Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey.

  J Gastroenterol. 2016; 51: 586-596.

• Kawaoka T, Imamura M, Morio K, Nakamura Y, Tsuge M, Nelson Hayes C, Kawakami Y, Aikata H, Ochi H, Ishiyama K, Ide K, Tashiro H, Ohdan H and Chayama K.

  Three patients treated with daclatasvir and asunaprevir for recurrent hepatitis C after liver transplantation: Case report.

  Hepatol Res. 2016; 46: 707-712.

• Asayama N, Oka S, Tanaka S, Sumimoto K, Hirano D, Tamaru Y, Ninomiya Y, Shigita K, Hayashi N, Nishiyama S and Chayama K.

  Clinical usefulness of a single-use splinting tube for poor endoscope operability in deep colonic endoscopic submucosal dissection.

  Endosc Int Open. 2016; 4: E614-617.

• Kobayashi T, Aikata H, Honda F, Nakano N, Nakamura Y, Hatooka M, Morio K, Morio R, Fukuhara T, Masaki K, Nagaoki Y, Kawaoka T, Tsuge M, Hiramatsu A, Imamura M, Kawakami Y, Ohdan H, Awai K and Chayama K.

  Preoperative Fluorine 18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography for Prediction of Microvascular Invasion in Small Hepatocellular Carcinoma.

  J Comput Assist Tomogr. 2016; 40: 524-530.

• Aly HH, Suzuki J, Watashi K, Chayama K, Hoshino S, Hijikata M, Kato T and Wakita T.

  RNA Exosome Complex Regulates Stability of the Hepatitis B Virus X-mRNA Transcript in a Non-stop-mediated (NSD) RNA Quality Control Mechanism.

  J Biol Chem. 2016; 291: 15958-15974.

• Numata N, Oka S, Tanaka S, Yoshifuku Y, Miwata T, Sanomura Y, Arihiro K, Shimamoto F and Chayama K.

  Useful condition of chromoendoscopy with indigo carmine and acetic acid for identifying a demarcation line prior to endoscopic submucosal dissection for early gastric cancer.

  BMC Gastroenterol. 2016; 16: 72.

• Shoji H, Yoshio S, Mano Y, Kumagai E, Sugiyama M, Korenaga M, Arai T, Itokawa N, Atsukawa M, Aikata H, Hyogo H, Chayama K, Ohashi T, Ito K, Yoneda M, Nozaki Y, Kawaguchi T, Torimura T, Abe M, Hiasa Y, Fukai M, Kamiyama T, Taketomi A, Mizokami M and Kanto T.

  Interleukin-34 as a fibroblast-derived marker of liver fibrosis in patients with non-alcoholic fatty liver disease.

  Sci Rep. 2016; 6: 28814.

• Hayes CN and Chayama K.

  HBV culture and infectious systems.

  Hepatol Int. 2016; 10: 559-566.

• Kagemoto K, Urabe Y, Miwata T, Oka S, Ochi H, Kitadai Y, Tanaka S and Chayama K.

  ADH1B and ALDH2 are associated with metachronous SCC after endoscopic submucosal dissection of esophageal squamous cell carcinoma.

  Cancer Med. 2016; 5: 1397-1404.

• Igawa A, Oka S, Tanaka S, Kunihara S, Nakano M and Chayama K.

  Polidocanol injection therapy for small-bowel hemangioma by using double-balloon endoscopy.

  Gastrointest Endosc. 2016; 84: 163-167.

• Asayama N, Oka S, Tanaka S, Nagata S, Furudoi A, Kuwai T, Onogawa S, Tamura T, Kanao H, Hiraga Y, Okanobu H, Kuwabara T, Kunihiro M, Mukai S, Goto E, Shimamoto F and Chayama K.

  Long-term outcomes after treatment for pedunculated-type T1 colorectal carcinoma: a multicenter retrospective cohort study.

  J Gastroenterol. 2016; 51: 702-710.

• Hatooka M, Kawaoka T, Aikata H, Morio K, Kobayashi T, Hiramatsu A, Imamura M, Kawakami Y, Murakami E, Waki K, Honda Y, Mori N, Takaki S, Tsuji K, Kohno H, Kohno H, Moriya T, Nonaka M, Hyogo H, Aisaka Y and Chayama K.

  Comparison of Outcome of Hepatic Arterial Infusion Chemotherapy and Sorafenib in Patients with Hepatocellular Carcinoma Refractory to Transcatheter Arterial Chemoembolization.

  Anticancer Res. 2016; 36: 3523-3529.

• Miyaki E, Imamura M, Hiraga N, Murakami E, Kawaoka T, Tsuge M, Hiramatsu A, Kawakami Y, Aikata H, Hayes CN and Chayama K.

  Daclatasvir and asunaprevir treatment improves liver function parameters and reduces liver fibrosis markers in chronic hepatitis C patients.

  Hepatol Res. 2016; 46: 758-764.

• Honda Y, Yoneda M, Kessoku T, Ogawa Y, Tomeno W, Imajo K, Mawatari H, Fujita K, Hyogo H, Ueno T, Chayama K, Saito S, Nakajima A and Hotta K.

  The characteristics of non-obese NAFLD: Effect of genetic and environmental factors.

  Hepatol Res. 2016; 46: 1011-1018.

• Murakami E, Tsuge M, Hiraga N, Kan H, Uchida T, Masaki K, Nakahara T, Ono A, Miki D, Kawaoka T, Abe H, Imamura M, Aikata H, Ochi H, Hayes CN, Akita T, Tanaka J and Chayama K.

  Effect of tenofovir disoproxil fumarate on drug-resistant HBV clones.

  J Infect. 2016; 72: 91-102.

• Hayakawa S, Okada S, Tsumura M, Sakata S, Ueno Y, Imai K, Morio T, Ohara O, Chayama K and Kobayashi M.

  A Patient with CTLA-4 Haploinsufficiency Presenting Gastric Cancer.

  J Clin Immunol. 2016; 36: 28-32.

• Kumada H, Suzuki F, Suzuki Y, Toyota J, Karino Y, Chayama K, Kawakami Y, Fujiyama S, Ito T, Itoh Y, Tamura E, Ueki T, Ishikawa H, Hu W, McPhee F, Linaberry M and Hughes E.

  Randomized comparison of daclatasvir + asunaprevir versus telaprevir + peginterferon/ribavirin in Japanese hepatitis C virus patients.

  J Gastroenterol Hepatol. 2016; 31: 14-22.

• Morio K, Imamura M, Kawakami Y, Morio R, Hatooka M, Kan H, Fujino H, Fukuhara T, Kobayashi T, Masaki K, Ono A, Nakahara T, Urabe A, Yokoyama S, Nagaoki Y, Kawaoka T, Hiraga N, Tsuge M, Hiramatsu A, Hayes CN, Aikata H, Ochi H, Chayama K and Hiroshima Liver Study G.

  ITPA polymorphism effects on decrease of hemoglobin during simeprevir, pegylated interferon and ribavirin combination treatment for chronic hepatitis C.

  Hepatol Res. 2016; 46: 1256-1263.

• Hayes CN and Chayama K.

  MicroRNAs as Biomarkers for Liver Disease and Hepatocellular Carcinoma.

  Int J Mol Sci. 2016; 17: 280.

• Uchida T, Hiraga N, Imamura M, Yoshimi S, Kan H, Miyaki E, Tsuge M, Abe H, Hayes CN, Aikata H, Ishida Y, Tateno C, Ellis JD and Chayama K.

  Elimination of HCV via a non-ISG-mediated mechanism by vaniprevir and BMS-788329 combination therapy in human hepatocyte chimeric mice.

  Virus Res. 2016; 213: 62-68.

• Asayama N, Oka S, Tanaka S and Chayama K.

  Area of Submucosal Invasion and Width of Invasion Predict Lymph Node Metastasis in pT1 Colorectal Cancers.

  Dis Colon Rectum. 2016; 59: e19.

• Tanimine N, Tanaka Y, Abe T, Piao J, Chayama K and Ohdan H.

  Functional Behavior of NKp46-Positive Intrahepatic Natural Killer Cells Against Hepatitis C Virus Reinfection After Liver Transplantation.

  Transplantation. 2016; 100: 355-364.

• Hayes CN, Zhang Y, Makokha GN, Hasan MZ, Omokoko MD and Chayama K.

  Early events in hepatitis B virus infection: From the cell surface to the nucleus.

  J Gastroenterol Hepatol. 2016; 31: 302-309.

• Krishnan P, Schnell G, Tripathi R, Beyer J, Reisch T, Zhang X, Setze C, Rodrigues L, Jr., Burroughs M, Redman R, Chayama K, Kumada H, Collins C and Pilot-Matias T.

  Analysis of Hepatitis C Virus Genotype 1b Resistance Variants in Japanese Patients Treated with Paritaprevir-Ritonavir and Ombitasvir.

  Antimicrob Agents Chemother. 2016; 60: 1106-1113.

• Kan H, Imamura M, Uchida T, Hiraga N, Hayes CN, Tsuge M, Abe H, Aikata H, Makokha GN, Chowdhury S, Miki D, Ochi H, Ishida Y, Tateno C and Chayama K.

  Protease Inhibitor Resistance Remains Even After Mutant Strains Become Undetectable by Deep Sequencing.

  J Infect Dis. 2016; 214: 1687-1694.

• Nakano N, Kawaoka T, Aikata H, Honda F, Nakamura Y, Morio K, Hatooka M, Fukuhara T, Kobayashi T, Hiramatsu A, Imamura M, Kawakami Y, Takahashi S and Chayama K.

  Complete response to short-term sorafenib treatment alone for hepatocellular carcinoma with bone, lymph node, and peritoneum metastases.

  Hepatol Res. 2016; 46: 1402-1408.

• Asayama N, Oka S, Tanaka S, Hirano D, Sumimoto K, Ninomiya Y, Tamaru Y, Shigita K, Hayashi N, Shimamoto F, Arihiro K and Chayama K.

  Pedunculated-type T1 colorectal carcinoma with lung carcinoma metastasis at the deepest invasive portion.

  Clin J Gastroenterol. 2016; 9: 208-214.

• Tsuge M, Hiramatsu A, Shinohara F, Nakano N, Nakamura Y, Hatooka M, Morio K, Morio R, Kan H, Fujino H, Uchida T, Kobayashi T, Fukuhara T, Masaki K, Nakahara T, Ono A, Nagaoki Y, Miki D, Kawaoka T, Hiraga N, Imamura M, Kawakami Y, Aikata H, Ochi H, Nelson Hayes C and Chayama K.

  Improvement of renal dysfunction in a patient with hepatitis C virus-related liver cirrhosis by daclatasvir and asunaprevir combination therapy: A case report.

  Hepatol Res. 2016; 46: 944-948.

• Sada H, Ohira M, Kobayashi T, Tashiro H, Chayama K and Ohdan H.

  An Analysis of Surgical Treatment for the Spontaneous Rupture of Hepatocellular Carcinoma.

  Dig Surg. 2016; 33: 43-50.

• Yuge R, Kitadai Y, Tanaka S, Uraoka N, Sentani K, Yasui W and Chayama K.

  Regression of Cecal MALT Lymphoma after Antibiotic Treatment in a Patient with Helicobacter pylori Infection.

  Intern Med. 2016; 55: 135-139.

• Tsuboi T, Sasaki T, Serikawa M, Ishii Y, Mouri T, Shimizu A, Kurihara K, Tatsukawa Y, Miyaki E, Kawamura R, Tsushima K, Murakami Y, Uemura K and Chayama K.

  Preoperative Biliary Drainage in Cases of Borderline Resectable Pancreatic Cancer Treated with Neoadjuvant Chemotherapy and Surgery.

  Gastroenterol Res Pract. 2016; 2016: 7968201.

• Kan H, Hiraga N, Imamura M, Hayes CN, Uchida T, Miyaki E, Tsuge M, Abe H, Aikata H, Miki D, Ochi H, Ishida Y, Tateno C and Chayama K.

  Combination therapies with daclatasvir and asunaprevir on NS3-D168 mutated HCV in human hepatocyte chimeric mice.

  Antivir Ther. 2016; 21: 307-315.

• Foster GR, Chayama K, Chuang WL, Fainboim H, Farkkila M, Gadano A, Gaeta GB, Hezode C, Inada Y, Heo J, Kumada H, Lu SN, Marcellin P, Moreno C, Roberts SK, Strasser SI, Thompson AJ, Toyota J, Paik SW, Vierling JM, Zignego AL, Cohen D, McPhee F, Wind-Rotolo M, Srinivasan S, Hruska M, Myler H and Portsmouth SD.

  A randomized, controlled study of peginterferon lambda-1a/ribavirin +/- daclatasvir for hepatitis C virus genotype 2 or 3.

  Springerplus. 2016; 5: 1365.

• Kunihara S, Oka S, Tanaka S, Otani I, Igawa A, Nagaoki Y, Aikata H and Chayama K.

  Third-Generation Capsule Endoscopy Outperforms Second-Generation Based on the Detectability of Esophageal Varices.

  Gastroenterol Res Pract. 2016; 2016: 9671327.