業績紹介

Achivement

2015年業績

• Kawaoka T, Aikata H, Hyogo H, Morio R, Morio K, Hatooka M, Fukuhara T, Kobayashi T, Naeshiro N, Miyaki D, Hiramatsu A, Imamura M, Kawakami Y, Takahashi S, Waki K, Tsuji K, Kohno H, Kohno H, Moriya T and Chayama K.

  Comparison of hepatic arterial infusion chemotherapy versus sorafenib monotherapy in patients with advanced hepatocellular carcinoma.

  J Dig Dis. 2015; 16: 505-512.

• Akamatsu S, Hayes CN, Ochi H, Uchida T, Kan H, Murakami E, Abe H, Tsuge M, Miki D, Akiyama R, Hiraga N, Imamura M, Aikata H, Kawaoka T, Kawakami Y and Chayama K.

  Association between variants in the interferon lambda 4 locus and substitutions in the hepatitis C virus non-structural protein 5A.

  J Hepatol. 2015; 63: 554-563.

• Onitake T, Ueno Y, Tanaka S, Sagami S, Hayashi R, Nagai K, Hide M and Chayama K.

  Pulverized konjac glucomannan ameliorates oxazolone-induced colitis in mice.

  Eur J Nutr. 2015; 54: 959-969.

• Uchida T, Hiraga N, Imamura M, Tsuge M, Abe H, Hayes CN, Aikata H, Ishida Y, Tateno C, Yoshizato K, Ohdan H, Murakami K and Chayama K.

  Human Cytotoxic T Lymphocyte-Mediated Acute Liver Failure and Rescue by Immunoglobulin in Human Hepatocyte Transplant TK-NOG Mice.

  J Virol. 2015; 89: 10087-10096.

• Ninomiya Y, Oka S, Tanaka S, Nishiyama S, Tamaru Y, Asayama N, Shigita K, Hayashi N and Chayama K.

  Risk of bleeding after endoscopic submucosal dissection for colorectal tumors in patients with continued use of low-dose aspirin.

  J Gastroenterol. 2015; 50: 1041-1046.

• Kitamura Y, Yoshihara M, Ito M, Boda T, Matsuo T, Kotachi T, Tanaka S and Chayama K.

  Diagnosis of Helicobacter pylori-induced gastritis by serum pepsinogen levels.

  J Gastroenterol Hepatol. 2015; 30: 1473-1477.

• Nakamura Y, Kimura T, Higaki T, Honda Y, Komoto D, Yamagami T, Iida M, Nagata Y, Honda Y, Aikata H, Chayama K and Awai K.

  Clinical utility of gadoxetate disodium-enhanced hepatic MRI for stereotactic body radiotherapy of hepatocellular carcinoma.

  Jpn J Radiol. 2015; 33: 627-635.

• Kumada H, Chayama K, Rodrigues L, Jr., Suzuki F, Ikeda K, Toyoda H, Sato K, Karino Y, Matsuzaki Y, Kioka K, Setze C, Pilot-Matias T, Patwardhan M, Vilchez RA, Burroughs M and Redman R.

  Randomized phase 3 trial of ombitasvir/paritaprevir/ritonavir for hepatitis C virus genotype 1b-infected Japanese patients with or without cirrhosis.

  Hepatology. 2015; 62: 1037-1046.

• Nakano R, Ohira M, Ide K, Ishiyama K, Kobayashi T, Tahara H, Tashiro H, Kuroda Y, Ichinohe T, Arihiro K, Chayama K and Ohdan H.

  Treatment of hepatic amyloid light-chain amyloidosis with bortezomib and dexamethasone in a liver transplant patient.

  Hepatol Res. 2015; 45: E150-155.

• Shakado S, Sakisaka S, Chayama K, Okanoue T, Toyoda J, Izumi N, Matsumoto A, Takehara T, Ido A, Hiasa Y, Yoshioka K, Nomura H, Ueno Y, Seike M and Kumada H.

  Alpha-fetoprotein and des-gamma-carboxy-prothrombin at twenty-four weeks after interferon-based therapy predict hepatocellular carcinoma development.

  World J Hepatol. 2015; 7: 2757-2764.

• Takahashi H, Ono M, Hyogo H, Tsuji C, Kitajima Y, Ono N, Eguchi T, Fujimoto K, Chayama K, Saibara T, Anzai K and Eguchi Y.

  Biphasic effect of alcohol intake on the development of fatty liver disease.

  J Gastroenterol. 2015; 50: 1114-1123.

• Nishiyama S, Oka S, Tanaka S, Sagami S, Nagai K, Ueno Y, Arihiro K and Chayama K.

  Clinical usefulness of endocytoscopy in the remission stage of ulcerative colitis: a pilot study.

  J Gastroenterol. 2015; 50: 1087-1093.

• Kan H, Yamagishi S, Ojima A, Fukami K, Ueda S, Takeuchi M, Hyogo H, Aikata H and Chayama K.

  Elevation of Serum Levels of Advanced Glycation End Products in Patients With Non-B or Non-C Hepatocellular Carcinoma.

  J Clin Lab Anal. 2015; 29: 480-484.

• Yoshimi S, Imamura M, Murakami E, Hiraga N, Tsuge M, Kawakami Y, Aikata H, Abe H, Hayes CN, Sasaki T, Ochi H and Chayama K.

  Long term persistence of NS5A inhibitor-resistant hepatitis C virus in patients who failed daclatasvir and asunaprevir therapy.

  J Med Virol. 2015; 87: 1913-1920.

• Kawaoka T, Takahashi S, Kawakami Y, Tsuge M, Hiramatsu A, Imamura M, Hyogo H, Aikata H, Ishiyama K, Tashiro H, Ohdan H, Tanaka J and Chayama K.

  Sustained virological response to antiviral therapy improves survival rate in patients with recurrent hepatitis C virus infection after liver transplantation.

  Hepatol Res. 2015; 45: 1047-1054.

• Hayashi R, Ueno Y, Tanaka S, Sagami S, Nagai K, Shigemoto N, Uegami S, Shimizu W, Watadani Y, Ohge H and Chayama K.

  Two Cases of Severe Ulcerative Colitis with Colonic Dilatation Resolved with Tacrolimus Therapy.

  Case Rep Gastroenterol. 2015; 9: 272-277.

• Chayama K, Notsumata K, Kurosaki M, Sato K, Rodrigues L, Jr., Setze C, Badri P, Pilot-Matias T, Vilchez RA and Kumada H.

  Randomized trial of interferon- and ribavirin-free ombitasvir/paritaprevir/ritonavir in treatment-experienced hepatitis C virus-infected patients.

  Hepatology. 2015; 61: 1523-1532.

• Ishitobi T, Hyogo H, Kan H, Hiramatsu A, Arihiro K, Aikata H and Chayama K.

  Eicosapentaenoic acid/arachidonic acid ratio as a possible link between non-alcoholic fatty liver disease and cardiovascular disease.

  Hepatol Res. 2015; 45: 533-539.

• Ishida Y, Yamasaki C, Yanagi A, Yoshizane Y, Fujikawa K, Watashi K, Abe H, Wakita T, Hayes CN, Chayama K and Tateno C.

  Novel robust in vitro hepatitis B virus infection model using fresh human hepatocytes isolated from humanized mice.

  Am J Pathol. 2015; 185: 1275-1285.

• Ishigaki T, Sasaki T, Serikawa M, Kobayashi K, Kamigaki M, Minami T, Okazaki A, Yukutake M, Ishii Y, Kosaka K, Mouri T, Yoshimi S and Chayama K.

  Evaluation of antibiotic use to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis and cholangitis.

  Hepatogastroenterology. 2015; 62: 417-424.

• Akamatsu S, Hayes CN, Tsuge M, Miki D, Akiyama R, Abe H, Ochi H, Hiraga N, Imamura M, Takahashi S, Aikata H, Kawaoka T, Kawakami Y, Ohishi W and Chayama K.

  Differences in serum microRNA profiles in hepatitis B and C virus infection.

  J Infect. 2015; 70: 273-287.

• Honda Y, Takahashi S, Zhang Y, Ono A, Murakami E, Shi N, Kawaoka T, Miki D, Tsuge M, Hiraga N, Abe H, Ochi H, Imamura M, Aikata H and Chayama K.

  Effects of bisphosphonate zoledronic acid in hepatocellular carcinoma, depending on mevalonate pathway.

  J Gastroenterol Hepatol. 2015; 30: 619-627.

• Hayes CN and Chayama K.

  Emerging treatments for chronic hepatitis C.

  J Formos Med Assoc. 2015; 114: 204-215.

• Kitamoto A, Kitamoto T, So R, Matsuo T, Nakata Y, Hyogo H, Ochi H, Nakamura T, Kamohara S, Miyatake N, Kotani K, Mineo I, Wada J, Ogawa Y, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Masuzaki H, Ueno T, Chayama K, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Sakata T, Tanaka K, Matsuzawa Y and Hotta K.

  ADIPOQ polymorphisms are associated with insulin resistance in Japanese women.

  Endocr J. 2015; 62: 513-521.

• Kobayashi T, Aikata H, Hatooka M, Morio K, Morio R, Kan H, Fujino H, Fukuhara T, Masaki K, Ohno A, Naeshiro N, Nakahara T, Honda Y, Murakami E, Kawaoka T, Tsuge M, Hiramatsu A, Imamura M, Kawakami Y, Hyogo H, Takahashi S and Chayama K.

  Usefulness of combining gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging and contrast-enhanced ultrasound for diagnosing the macroscopic classification of small hepatocellular carcinoma.

  Eur Radiol. 2015; 25: 3272-3281.

• Naeshiro N, Aikata H, Hyogo H, Kan H, Fujino H, Kobayashi T, Fukuhara T, Honda Y, Nakahara T, Ohno A, Miyaki D, Murakami E, Kawaoka T, Tsuge M, Hiraga N, Hiramatsu A, Imamura M, Kawakami Y, Ochi H and Chayama K.

  Efficacy and safety of the anticoagulant drug, danaparoid sodium, in the treatment of portal vein thrombosis in patients with liver cirrhosis.

  Hepatol Res. 2015; 45: 656-662.

• Fujino H, Kimura T, Aikata H, Miyaki D, Kawaoka T, Kan H, Fukuhara T, Kobayashi T, Naeshiro N, Honda Y, Tsuge M, Hiramatsu A, Imamura M, Kawakami Y, Hyogo H, Takahashi S, Yoshimatsu R, Yamagami T, Kenjo M, Nagata Y, Awai K and Chayama K.

  Role of 3-D conformal radiotherapy for major portal vein tumor thrombosis combined with hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma.

  Hepatol Res. 2015; 45: 607-617.

• Honda Y, Kawaoka T, Aikata H, Kan H, Fujino H, Kobayashi T, Fukuhara T, Naeshiro N, Hiramatsu A, Imamura M, Kawakami Y, Hyogo H, Arihiro K and Chayama K.

  Disseminated carcinomatosis of the bone marrow originating from hepatocellular carcinoma. A case report.

  Hepatol Res. 2015; 45: 705-710.

• Huang YW, Chayama K, Kao JH and Yang SS.

  Detectability and clinical significance of serum hepatitis B virus ribonucleic acid.

  Hepatobiliary Surg Nutr. 2015; 4: 197-202.

• Kamada Y, Ono M, Hyogo H, Fujii H, Sumida Y, Mori K, Tanaka S, Yamada M, Akita M, Mizutani K, Fujii H, Yamamoto A, Takamatsu S, Yoshida Y, Itoh Y, Kawada N, Chayama K, Saibara T, Takehara T and Miyoshi E.

  A novel noninvasive diagnostic method for nonalcoholic steatohepatitis using two glycobiomarkers.

  Hepatology. 2015; 62: 1433-1443.

• Kumada H, Sato K, Takehara T, Nakamuta M, Ishigami M, Chayama K, Toyota J, Suzuki F, Nakayasu Y, Ochi M, Yamada I and Okanoue T.

  Efficacy of telaprevir-based therapy for difficult-to-treat patients with genotype 2 chronic hepatitis C in Japan.

  Hepatol Res. 2015; 45: 745-754.

• McPhee F, Suzuki Y, Toyota J, Karino Y, Chayama K, Kawakami Y, Yu ML, Ahn SH, Ishikawa H, Bhore R, Zhou N, Hernandez D, Mendez P and Kumada H.

  High Sustained Virologic Response to Daclatasvir Plus Asunaprevir in Elderly and Cirrhotic Patients with Hepatitis C Virus Genotype 1b Without Baseline NS5A Polymorphisms.

  Adv Ther. 2015; 32: 637-649.

• Tamaru Y, Oka S, Tanaka S, Ninomiya Y, Asayama N, Shigita K, Nishiyama S, Hayashi N, Arihiro K and Chayama K.

  Early squamous cell carcinoma of the anal canal resected by endoscopic submucosal dissection.

  Case Rep Gastroenterol. 2015; 9: 120-125.

• Matsumoto A, Yatsuhashi H, Nagaoka S, Suzuki Y, Hosaka T, Tsuge M, Chayama K, Kanda T, Yokosuka O, Nishiguchi S, Saito M, Miyase S, Kang JH, Shinkai N, Tanaka Y, Umemura T and Tanaka E.

  Factors associated with the effect of interferon-alpha sequential therapy in order to discontinue nucleoside/nucleotide analog treatment in patients with chronic hepatitis B.

  Hepatol Res. 2015; 45: 1195-1202.

• Chayama K, Mitsui F and Hayes CN.

  Optimizing triple therapy and IFN/RBV-free regimens for hepatitis C virus infection.

  Expert Rev Gastroenterol Hepatol. 2015; 9: 21-30.

• Tanaka S, Asayama N, Shigita K, Hayashi N, Oka S and Chayama K.

  Towards safer and appropriate application of endoscopic submucosal dissection for T1 colorectal carcinoma as total excisional biopsy: future perspectives.

  Dig Endosc. 2015; 27: 216-222.

• Aoyama T, Oka S, Aikata H, Igawa A, Nakano M, Naeshiro N, Yoshida S, Tanaka S and Chayama K.

  Major predictors of portal hypertensive enteropathy in patients with liver cirrhosis.

  J Gastroenterol Hepatol. 2015; 30: 124-130.

• Hiyama T, Quach DT, Le QD, Ho LX, Vu NH, Shimamoto F, Ito M, Tanaka S, Yoshihara M, Uemura N and Chayama K.

  Rate of unintended Helicobacter pylori eradication in the Vietnamese.

  Helicobacter. 2015; 20: 156-157.

• Yuge R, Kitadai Y, Shinagawa K, Onoyama M, Tanaka S, Yasui W and Chayama K.

  mTOR and PDGF pathway blockade inhibits liver metastasis of colorectal cancer by modulating the tumor microenvironment.

  Am J Pathol. 2015; 185: 399-408.

• Yokoyama S, Kawakami Y, Imamura M, Hayes CN, Kohno H, Kohno H, Tsuji K, Aisaka Y, Kira S, Yamashina K, Nonaka M, Takahashi S, Moriya T, Kitamoto M, Aimitsu S, Nakanishi T, Kawakami H and Chayama K.

  Effect of prolonged administration of pegylated interferon/ribavirin therapy in genotypes 2a and 2b: propensity score-matched analysis.

  J Gastroenterol Hepatol. 2015; 30: 337-344.

• Akamatsu S, Hayes CN, Tsuge M, Murakami E, Hiraga N, Abe H, Miki D, Imamura M, Ochi H, Chayama K and Hiroshima Liver Study G.

  Ribavirin dose reduction during telaprevir/ribavirin/peg-interferon therapy overcomes the effect of the ITPA gene polymorphism.

  J Viral Hepat. 2015; 22: 166-174.

• Miyaki R, Yoshida S, Tanaka S, Kominami Y, Sanomura Y, Matsuo T, Oka S, Raytchev B, Tamaki T, Koide T, Kaneda K, Yoshihara M and Chayama K.

  A computer system to be used with laser-based endoscopy for quantitative diagnosis of early gastric cancer.

  J Clin Gastroenterol. 2015; 49: 108-115.

• Kosaka K, Imamura M, Hayes CN, Abe H, Hiraga N, Yoshimi S, Murakami E, Kawaoka T, Tsuge M, Aikata H, Miki D, Ochi H, Matsui H, Kanai A, Inaba T and Chayama K.

  Emergence of resistant variants detected by ultra-deep sequencing after asunaprevir and daclatasvir combination therapy in patients infected with hepatitis C virus genotype 1.

  J Viral Hepat. 2015; 22: 158-165.

• Kong SY, Takeuchi M, Hyogo H, McKeown-Eyssen G, Yamagishi S, Chayama K, O'Brien PJ, Ferrari P, Overvad K, Olsen A, Tjonneland A, Boutron-Ruault MC, Bastide N, Carbonnel F, Kuhn T, Kaaks R, Boeing H, Aleksandrova K, Trichopoulou A, Lagiou P, Vasilopoulou E, Masala G, Pala V, Santucci De Magistris M, Tumino R, Naccarati A, Bueno-de-Mesquita HB, Peeters PH, Weiderpass E, Quiros JR, Jakszyn P, Sanchez MJ, Dorronsoro M, Gavrila D, Ardanaz E, Rutegard M, Nystrom H, Wareham NJ, Khaw KT, Bradbury KE, Romieu I, Freisling H, Stavropoulou F, Gunter MJ, Cross AJ, Riboli E, Jenab M and Bruce WR.

  The Association between Glyceraldehyde-Derived Advanced Glycation End-Products and Colorectal Cancer Risk.

  Cancer Epidemiol Biomarkers Prev. 2015; 24: 1855-1863.

• Fukuhara T, Aikata H, Hyogo H, Honda Y, Morio K, Morio R, Hatooka M, Kobayashi T, Naeshiro N, Kawaoka T, Tsuge M, Hiramatsu A, Imamura M, Kawakami Y and Chayama K.

  Efficacy of radiofrequency ablation for initial recurrent hepatocellular carcinoma after curative treatment: Comparison with primary cases.

  Eur J Radiol. 2015; 84: 1540-1545.

• He S, Lin B, Chu V, Hu Z, Hu X, Xiao J, Wang AQ, Schweitzer CJ, Li Q, Imamura M, Hiraga N, Southall N, Ferrer M, Zheng W, Chayama K, Marugan JJ and Liang TJ.

  Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection.

  Sci Transl Med. 2015; 7: 282ra249.

• Miyaki D, Kawaoka T, Aikata H, Kan H, Fujino H, Fukuhara T, Kobayashi T, Naeshiro N, Honda Y, Tsuge M, Hiramatsu A, Imamura M, Hyogo H, Kawakami Y, Yoshimatsu R, Yamagami T, Awai K and Chayama K.

  Evaluation of early response to hepatic arterial infusion chemotherapy in patients with advanced hepatocellular carcinoma using the combination of response evaluation criteria in solid tumors and tumor markers.

  J Gastroenterol Hepatol. 2015; 30: 726-732.

• Kimura T, Aikata H, Takahashi S, Takahashi I, Nishibuchi I, Doi Y, Kenjo M, Murakami Y, Honda Y, Kakizawa H, Awai K, Chayama K and Nagata Y.

  Stereotactic body radiotherapy for patients with small hepatocellular carcinoma ineligible for resection or ablation therapies.

  Hepatol Res. 2015; 45: 378-386.

• Numata N, Oka S, Tanaka S, Kagemoto K, Sanomura Y, Yoshida S, Arihiro K, Shimamoto F and Chayama K.

  Risk factors and management of positive horizontal margin in early gastric cancer resected by en bloc endoscopic submucosal dissection.

  Gastric Cancer. 2015; 18: 332-338.

• Kawaoka T, Imamura M, Kan H, Fujino H, Fukuhara T, Kobayashi T, Honda Y, Naeshiro N, Hiramatsu A, Tsuge M, Hayes CN, Kawakami Y, Aikata H, Ochi H, Ishiyama K, Tashiro H, Ohdan H and Chayama K.

  Two patients treated with simeprevir plus pegylated-interferon and ribavirin triple therapy for recurrent hepatitis C after living donor liver transplantation: case report.

  Transplant Proc. 2015; 47: 809-814.

• Asayama N, Oka S, Tanaka S, Hayashi N, Arihiro K and Chayama K.

  Endoscopic submucosal dissection as total excisional biopsy for clinical T1 colorectal carcinoma.

  Digestion. 2015; 91: 64-69.

• Fujimoto A, Furuta M, Shiraishi Y, Gotoh K, Kawakami Y, Arihiro K, Nakamura T, Ueno M, Ariizumi S, Nguyen HH, Shigemizu D, Abe T, Boroevich KA, Nakano K, Sasaki A, Kitada R, Maejima K, Yamamoto Y, Tanaka H, Shibuya T, Shibata T, Ojima H, Shimada K, Hayami S, Shigekawa Y, Aikata H, Ohdan H, Marubashi S, Yamada T, Kubo M, Hirano S, Ishikawa O, Yamamoto M, Yamaue H, Chayama K, Miyano S, Tsunoda T and Nakagawa H.

  Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity.

  Nat Commun. 2015; 6: 6120.

• Yoshimi S, Ochi H, Murakami E, Uchida T, Kan H, Akamatsu S, Hayes CN, Abe H, Miki D, Hiraga N, Imamura M, Aikata H and Chayama K.

  Rapid, Sensitive, and Accurate Evaluation of Drug Resistant Mutant (NS5A-Y93H) Strain Frequency in Genotype 1b HCV by Invader Assay.

  PLoS One. 2015; 10: e0130022.

• Kimura T, Takahashi S, Takahashi I, Nishibuchi I, Doi Y, Kenjo M, Murakami Y, Honda Y, Aikata H, Chayama K and Nagata Y.

  The Time Course of Dynamic Computed Tomographic Appearance of Radiation Injury to the Cirrhotic Liver Following Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma.

  PLoS One. 2015; 10: e0125231.

• Igawa A, Oka S, Tanaka S, Kunihara S, Nakano M, Aoyama T and Chayama K.

  Major predictors and management of small-bowel angioectasia.

  BMC Gastroenterol. 2015; 15 108

• Miwata T, Quach DT, Hiyama T, Aoki R, Le HM, Tran PL, Ito M, Tanaka S, Arihiro K, Uemura N and Chayama K.

  Interobserver and intraobserver agreement for gastric mucosa atrophy.

  BMC Gastroenterol. 2015; 15: 95.

• Huang YW, Takahashi S, Tsuge M, Chen CL, Wang TC, Abe H, Hu JT, Chen DS, Yang SS, Chayama K and Kao JH.

  On-treatment low serum HBV RNA level predicts initial virological response in chronic hepatitis B patients receiving nucleoside analogue therapy.

  Antivir Ther. 2015; 20: 369-375.

• Kominami Y, Yoshida S, Tanaka S, Miyaki R, Sanomura Y, Seo MW, Kagawa K, Kawahito S, Arimoto H, Yamada K and Chayama K.

  Evaluation of dual-wavelength excitation autofluorescence imaging of colorectal tumours with a high-sensitivity CMOS imager: a cross-sectional study.

  BMC Gastroenterol. 2015; 15: 110.

• Sagami S, Ueno Y, Tanaka S, Nagai K, Hayashi R and Chayama K.

  Successful Use of Adalimumab for Treating Pyoderma Gangrenosum with Ulcerative Colitis under Corticosteroid-tapering Conditions.

  Intern Med. 2015; 54: 2167-2172.

• Leong CR, Oshiumi H, Okamoto M, Azuma M, Takaki H, Matsumoto M, Chayama K and Seya T.

  A MAVS/TICAM-1-independent interferon-inducing pathway contributes to regulation of hepatitis B virus replication in the mouse hydrodynamic injection model.

  J Innate Immun. 2015; 7 47-58.

• Chayama K and Hayes CN.

  HCV Drug Resistance Challenges in Japan: The Role of Pre-Existing Variants and Emerging Resistant Strains in Direct Acting Antiviral Therapy.

  Viruses. 2015; 7: 5328-5342.

• Ono A FA, Yamamoto Y, Akamatsu S, Hiraga N, Imamura M, Kawaoka T, Tsuge M, Abe H, C. Nelson Hayes, Miki D, Furuta M, Tsunoda T, Miyano S, Kubo M, Aikata H, Ochi H, Kawakami Y, Arihiro K, Ohdan H, Nakagawa H, Chayama K.

  Circulating Tumor DNA Analysis for Liver Cancers and Its Usefulness as a Liquid Biopsy.

  CMGH. 2015; 1: 516-534.