業績紹介

Achivement

2014年業績

• Hara Y, Yanatori I, Ikeda M, Kiyokage E, Nishina S, Tomiyama Y, Toida K, Kishi F, Kato N, Imamura M, Chayama K and Hino K.

  Hepatitis C virus core protein suppresses mitophagy by interacting with parkin in the context of mitochondrial depolarization.

  Am J Pathol. 2014; 184: 3026-3039.

• Shakado S, Sakisaka S, Okanoue T, Chayama K, Izumi N, Toyoda J, Tanaka E, Ido A, Takehara T, Yoshioka K, Hiasa Y, Nomura H, Seike M, Ueno Y and Kumada H.

  Interleukin 28B polymorphism predicts interferon plus ribavirin treatment outcome in patients with hepatitis C virus-related liver cirrhosis: A multicenter retrospective study in Japan.

  Hepatol Res. 2014; 44: 983-992.

• Tanaka Y, Ohira M, Tashiro H, Imamura M, Chayama K and Ohdan H.

  Impact of alloimmune T cell responses on hepatitis C virus replication in liver transplant recipients.

  Hum Immunol. 2014; 75: 1259-1267.

• Takahashi S, Kimura T, Kenjo M, Nishibuchi I, Takahashi I, Takeuchi Y, Doi Y, Kaneyasu Y, Murakami Y, Honda Y, Aikata H, Chayama K and Nagata Y.

  Case reports of portal vein thrombosis and bile duct stenosis after stereotactic body radiation therapy for hepatocellular carcinoma.

  Hepatol Res. 2014; 44: E273-278.

• Miwata T, Hiyama T, Quach D, Le H, Hua H, Oka S, Tanaka S, Arihiro K and Chayama K.

  Differences in K- ras and mitochondrial DNA mutations and microsatellite instability between colorectal cancers of Vietnamese and Japanese patients.

  BMC Gastroenterol. 2014; 14: 203.

• Shahidi M, Tay ES, Read SA, Ramezani-Moghadam M, Chayama K, George J and Douglas MW.

  Endocannabinoid CB1 antagonists inhibit hepatitis C virus production, providing a novel class of antiviral host-targeting agents.

  J Gen Virol. 2014; 95: 2468-2479.

• Tanaka K, Hyogo H, Ono M, Takahashi H, Kitajima Y, Ono N, Eguchi T, Fujimoto K, Chayama K, Saibara T, Anzai K, Eguchi Y and Japan Study Group of Non-alcoholic Fatty Liver D.

  Upper limit of normal serum alanine aminotransferase levels in Japanese subjects.

  Hepatol Res. 2014; 44: 1196-1207.

• Nakahara T, Hyogo H, Yoneda M, Sumida Y, Eguchi Y, Fujii H, Ono M, Kawaguchi T, Imajo K, Aikata H, Tanaka S, Kanemasa K, Fujimoto K, Anzai K, Saibara T, Sata M, Nakajima A, Itoh Y, Chayama K, Okanoue T and Japan Study Group of Nonalcoholic Fatty Liver D.

  Type 2 diabetes mellitus is associated with the fibrosis severity in patients with nonalcoholic fatty liver disease in a large retrospective cohort of Japanese patients.

  J Gastroenterol. 2014; 49: 1477-1484.

• Yokoyama S, Takahashi S, Kawakami Y, Hayes CN, Kohno H, Kohno H, Tsuji K, Aisaka Y, Kira S, Yamashina K, Nonaka M, Moriya T, Kitamoto M, Aimitsu S, Nakanishi T, Kawakami H and Chayama K.

  Effect of vitamin D supplementation on pegylated interferon/ribavirin therapy for chronic hepatitis C genotype 1b: a randomized controlled trial.

  J Viral Hepat. 2014; 21: 348-356.

• Naeshiro N, Aikata H, Kakizawa H, Hyogo H, Kan H, Fujino H, Kobayashi T, Fukuhara T, Honda Y, Ohno A, Miyaki D, Kawaoka T, Tsuge M, Hiraga N, Hiramatsu A, Imamura M, Kawakami Y, Takahashi S, Awai K and Chayama K.

  Long-term outcome of patients with gastric varices treated by balloon-occluded retrograde transvenous obliteration.

  J Gastroenterol Hepatol. 2014; 29: 1035-1042.

• Fukuhara T, Hyogo H, Ochi H, Fujino H, Kan H, Naeshiro N, Honda Y, Miyaki D, Kawaoka T, Tsuge M, Hiramatsu A, Imamura M, Kawakami Y, Aikata H and Chayama K.

  Efficacy and safety of sitagliptin for the treatment of nonalcoholic fatty liver disease with type 2 diabetes mellitus.

  Hepatogastroenterology. 2014; 61: 323-328.

• Kan H, Kimura Y, Hyogo H, Fukuhara T, Fujino H, Naeshiro N, Honda Y, Kawaoka T, Tsuge M, Hiramatsu A, Imamura M, Kawakami Y, Aikata H, Ochi H, Arihiro K and Chayama K.

  Non-invasive assessment of liver steatosis in non-alcoholic fatty liver disease.

  Hepatol Res. 2014; 44: E420-427.

• Nishiyama S, Oka S, Tanaka S, Hayashi N, Hayashi R, Nagai K, Ueno Y, Shimamoto F, Arihiro K and Chayama K.

  Is it possible to discriminate between neoplastic and nonneoplastic lesions in ulcerative colitis by magnifying colonoscopy?

  Inflamm Bowel Dis. 2014; 20: 508-513.

• Abe H, Kimura A, Tsuruta S, Fukaya T, Sakaguchi R, Morita R, Sekiya T, Shichita T, Chayama K, Fujii-Kuriyama Y and Yoshimura A.

  Aryl hydrocarbon receptor plays protective roles in ConA-induced hepatic injury by both suppressing IFN-gamma expression and inducing IL-22.

  Int Immunol. 2014; 26: 129-137.

• Ochi H, Miki D, Hayes CN, Abe H, Hayashida Y, Kubo M and Chayama K.

  IFNL4/IL-28B haplotype structure and its impact on susceptibility to hepatitis C virus and treatment response in the Japanese population.

  J Gen Virol. 2014; 95: 1297-1306.

• Kumada H, Suzuki Y, Ikeda K, Toyota J, Karino Y, Chayama K, Kawakami Y, Ido A, Yamamoto K, Takaguchi K, Izumi N, Koike K, Takehara T, Kawada N, Sata M, Miyagoshi H, Eley T, McPhee F, Damokosh A, Ishikawa H and Hughes E.

  Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection.

  Hepatology. 2014; 59: 2083-2091.

• Sanomura Y, Oka S, Tanaka S, Numata N, Higashiyama M, Kanao H, Yoshida S, Ueno Y and Chayama K.

  Continued use of low-dose aspirin does not increase the risk of bleeding during or after endoscopic submucosal dissection for early gastric cancer.

  Gastric Cancer. 2014; 17: 489-496.

• Oka S, Tanaka S and Chayama K.

  Detection of nonpolypoid colorectal neoplasia using magnifying endoscopy in colonic inflammatory bowel disease.

  Gastrointest Endosc Clin N Am. 2014; 24: 405-417.

• Taketani H, Sumida Y, Tanaka S, Imajo K, Yoneda M, Hyogo H, Ono M, Fujii H, Eguchi Y, Kanemasa K, Chayama K, Itoh Y, Yoshikawa T, Saibara T, Fujimoto K, Nakajima A and Japan Study Group of N.

  The association of insomnia with gastroesophageal reflux symptoms in biopsy-proven nonalcoholic fatty liver disease.

  J Gastroenterol. 2014; 49: 1163-1174.

• Naeshiro N, Kakizawa H, Aikata H, Kan H, Fujino H, Fukuhara T, Kobayashi T, Honda Y, Miyaki D, Kawaoka T, Tsuge M, Hiramatsu A, Imamura M, Kawakami Y, Hyogo H, Ishikawa M, Awai K and Chayama K.

  Percutaneous transvenous embolization for portosystemic shunts associated with encephalopathy: Long-term outcomes in 14 patients.

  Hepatol Res. 2014; 44: 740-749.

• Honda Y, Kimura T, Aikata H, Nakahara T, Naeshiro N, Tanaka M, Miyaki D, Nagaoki Y, Kawaoka T, Takaki S, Hiramatsu A, Waki K, Ishikawa M, Kakizawa H, Kenjo M, Awai K, Nagata Y and Chayama K.

  Pilot study of stereotactic body radiation therapy combined with transcatheter arterial chemoembolization for small hepatocellular carcinoma.

  Hepatogastroenterology. 2014; 61: 31-36.

• McPhee F, Hernandez D, Zhou N, Yu F, Ueland J, Monikowski A, Chayama K, Toyota J, Izumi N, Yokosuka O, Kawada N, Osaki Y, Hughes EA, Watanabe H, Ishikawa H and Kumada H.

  Virological escape in HCV genotype-1-infected patients receiving daclatasvir plus ribavirin and peginterferon alfa-2a or alfa-2b.

  Antivir Ther. 2014; 19: 479-490.

• Yokoyama S, Kawakami Y and Chayama K.

  Letter: Pitavastatin supplementation of PEG-IFN/ribavirin improves sustained virological response against HCV.

  Aliment Pharmacol Ther. 2014; 39: 443-444.

• Tanimine N, Tanaka Y, Kobayashi T, Tashiro H, Miki D, Imamura M, Aikata H, Tanaka J, Chayama K and Ohdan H.

  Quantitative effect of natural killer-cell licensing on hepatocellular carcinoma recurrence after curative hepatectomy.

  Cancer Immunol Res. 2014; 2: 1142-1147.

• Fujino H, Imamura M, Nagaoki Y, Kawakami Y, Abe H, Hayes CN, Kan H, Fukuhara T, Kobayashi T, Masaki K, Ono A, Nakahara T, Honda Y, Naeshiro N, Urabe A, Yokoyama S, Miyaki D, Murakami E, Kawaoka T, Hiraga N, Tsuge M, Hiramatsu A, Hyogo H, Aikata H, Takahashi S, Miki D, Ochi H, Ohishi W, Chayama K and Hiroshima Liver Study G.

  Predictive value of the IFNL4 polymorphism on outcome of telaprevir, peginterferon, and ribavirin therapy for older patients with genotype 1b chronic hepatitis C.

  J Gastroenterol. 2014; 49: 1548-1556.

• Kessoku T, Ogawa Y, Yoneda M, Imajo K, Sumida Y, Eguchi Y, Fujii H, Hyogo H, Ono M, Suzuki Y, Kawaguchi T, Chayama K, Tanaka S, Fujimoto K, Anzai K, Saibara T, Sata M, Itoh Y, Nakajima A, Okanoue T and Japan Study Group of N.

  Simple scoring system for predicting cirrhosis in nonalcoholic fatty liver disease.

  World J Gastroenterol. 2014; 20: 10108-10114.

• Nagaoki Y, Imamura M, Kawakami Y, Kan H, Fujino H, Fukuhara T, Kobayashi T, Ono A, Nakahara T, Naeshiro N, Urabe A, Yokoyama S, Miyaki D, Murakami E, Kawaoka T, Tsuge M, Hiramatsu A, Aikata H, Takahashi S, Hayes CN, Ochi H, Chayama K and Hiroshima Liver Study G.

  Interferon lambda 4 polymorphism affects on outcome of telaprevir, pegylated interferon and ribavirin combination therapy for chronic hepatitis C.

  Hepatol Res. 2014; 44: E447-454.

• Oka S, Tanaka S, Nakadoi K, Asayama N and Chayama K.

  Endoscopic features and management of diminutive colorectal submucosal invasive carcinoma.

  Dig Endosc. 2014; 26: S78-83.

• Saibara T, Enomoto N, Kaneko S, Chayama K, Sata M, Imawari M, Onishi S and Okita K.

  Clinical efficacy of combination therapy with ME3738 and pegylated interferon-alpha-2a in patients with hepatitis C virus genotype 1.

  Hepatol Res. 2014; 44: 410-419.

• Ishitobi T, Hyogo H, Tokumo H, Arihiro K and Chayama K.

  Efficacy of probucol for the treatment of non-alcoholic steatohepatitis with dyslipidemia: An open-label pilot study.

  Hepatol Res. 2014; 44: 429-435.

• Abe H, Hayes CN and Chayama K.

  New insight into the enhanced effect of pegylated interferon-alpha.

  Hepatology. 2014; 60: 1435-1437.

• Kohno T, Tsuge M, Murakami E, Hiraga N, Abe H, Miki D, Imamura M, Ochi H, Hayes CN and Chayama K.

  Human microRNA hsa-miR-1231 suppresses hepatitis B virus replication by targeting core mRNA.

  J Viral Hepat. 2014; 21: e89-97.

• Minami T, Sasaki T, Serikawa M, Ishigaki T, Murakami Y and Chayama K.

  Antibiotic prophylaxis for endoscopic retrograde chlangiopancreatography increases the detection rate of drug-resistant bacteria in bile.

  J Hepatobiliary Pancreat Sci. 2014; 21: 712-718.

• Kitamura Y, Ito M, Matsuo T, Boda T, Oka S, Yoshihara M, Tanaka S and Chayama K.

  Characteristic epithelium with low-grade atypia appears on the surface of gastric cancer after successful Helicobacter pylori eradication therapy.

  Helicobacter. 2014; 19: 289-295.

• Kagemoto K, Oka S, Tanaka S, Miwata T, Urabe Y, Sanomura Y, Yoshida S, Hiyama T, Arihiro K and Chayama K.

  Clinical outcomes of endoscopic submucosal dissection for superficial Barrett's adenocarcinoma.

  Gastrointest Endosc. 2014; 80: 239-245.

• Kitamoto A, Kitamoto T, Nakamura T, Ogawa Y, Yoneda M, Hyogo H, Ochi H, Mizusawa S, Ueno T, Nakao K, Sekine A, Chayama K, Nakajima A and Hotta K.

  Association of polymorphisms in GCKR and TRIB1 with nonalcoholic fatty liver disease and metabolic syndrome traits.

  Endocr J. 2014; 61: 683-689.

• Terasaki M, Tanaka S, Shigita K, Asayama N, Nishiyama S, Hayashi N, Nakadoi K, Oka S and Chayama K.

  Risk factors for delayed bleeding after endoscopic submucosal dissection for colorectal neoplasms.

  Int J Colorectal Dis. 2014; 29: 877-882.

• Kitamoto T, Kitamoto A, Yoneda M, Hyogo H, Ochi H, Mizusawa S, Ueno T, Nakao K, Sekine A, Chayama K, Nakajima A and Hotta K.

  Targeted next-generation sequencing and fine linkage disequilibrium mapping reveals association of PNPLA3 and PARVB with the severity of nonalcoholic fatty liver disease.

  J Hum Genet. 2014; 59: 241-246.

• Nakadoi K, Oka S, Tanaka S, Hayashi N, Terasaki M, Arihiro K, Shimamoto F and Chayama K.

  Condition of muscularis mucosae is a risk factor for lymph node metastasis in T1 colorectal carcinoma.

  Surg Endosc. 2014; 28: 1269-1276.

• Hayashi N, Tanaka S, Nishiyama S, Terasaki M, Nakadoi K, Oka S, Yoshihara M and Chayama K.

  Predictors of incomplete resection and perforation associated with endoscopic submucosal dissection for colorectal tumors.

  Gastrointest Endosc. 2014; 79: 427-435.

• Ishigaki T, Sasaki T, Serikawa M, Minami T, Okazaki A, Yukutake M, Ishii Y, Kosaka K, Mouri T, Yoshimi S and Chayama K.

  Comparative study of 4 Fr versus 6 Fr nasobiliary drainage catheters: a randomized, controlled trial.

  J Gastroenterol Hepatol. 2014; 29: 653-659.

• Aoyama T, Oka S, Aikata H, Nakano M, Watari I, Naeshiro N, Yoshida S, Tanaka S and Chayama K.

  Is small-bowel capsule endoscopy effective for diagnosis of esophagogastric lesions related to portal hypertension?

  J Gastroenterol Hepatol. 2014; 29: 511-516.

• Ishikawa M, Yamagami T, Kakizawa H, Hieda M, Toyota N, Fukumoto W, Kajiwara K, Yoshimatsu R, Aikata H, Chayama K and Awai K.

  Transarterial therapy of hepatocellular carcinoma fed by the right renal capsular artery.

  J Vasc Interv Radiol. 2014; 25: 389-395.

• Takaki S, Kawakami Y, Miyaki D, Nakahara T, Naeshiro N, Murakami E, Tanaka M, Honda Y, Yokoyama S, Nagaoki Y, Kawaoka T, Hiramatsu A, Tsuge M, Hiraga N, Imamura M, Hyogo H, Aikata H, Takahashi S, Arihiro K and Chayama K.

  Non-invasive liver fibrosis score calculated by combination of virtual touch tissue quantification and serum liver functional tests in chronic hepatitis C patients.

  Hepatol Res. 2014; 44: 280-287.

• Takahashi Y, Ando M, Nishikawa M, Hiraga N, Imamura M, Chayama K and Takakura Y.

  Long-term elimination of hepatitis C virus from human hepatocyte chimeric mice after interferon-gamma gene transfer.

  Hum Gene Ther Clin Dev. 2014; 25: 28-39.

• Kawaoka T, Aikata H, Kan H, Fujino H, Fukuhara T, Kobayashi T, Naeshiro N, Miyaki D, Hiramatsu A, Imamura M, Kawakami Y, Hyogo H and Chayama K.

  Clinical outcome and prognostic factors of patients with hepatocellular carcinoma and extrahepatic metastasis treated with sorafenib.

  Hepatol Res. 2014; 44: 1320-1328.

• Boda T, Ito M, Yoshihara M, Kitamura Y, Matsuo T, Oka S, Tanaka S and Chayama K.

  Advanced method for evaluation of gastric cancer risk by serum markers: determination of true low-risk subjects for gastric neoplasm.

  Helicobacter. 2014; 19: 1-8.

• Hyogo H, Yamagishi S, Maeda S, Fukami K, Ueda S, Okuda S, Nakahara T, Kimura Y, Ishitobi T and Chayama K.

  Serum asymmetric dimethylarginine levels are independently associated with procollagen III N-terminal peptide in nonalcoholic fatty liver disease patients.

  Clin Exp Med. 2014; 14: 45-51.

• Oka S, Tanaka S, Higashiyama M, Numata N, Sanomura Y, Yoshida S, Arihiro K and Chayama K.

  Clinical validity of the expanded criteria for endoscopic resection of undifferentiated-type early gastric cancer based on long-term outcomes.

  Surg Endosc. 2014; 28: 639-647.

• Suzuki F, Toyota J, Ikeda K, Chayama K, Mochida S, Hayashi N, Ishikawa H, Miyagoshi H, Hu W, McPhee F, Hughes EA and Kumada H.

  A randomized trial of daclatasvir with peginterferon alfa-2b and ribavirin for HCV genotype 1 infection.

  Antivir Ther. 2014; 19: 491-499.

• Kawaoka T, Takahashi S, Tatsukawa Y, Hiramatsu A, Hiraga N, Miki D, Tsuge M, Imamura M, Kawakami Y, Aikata H, Ochi H, Ishiyama K, Ide K, Tashiro H, Ohdan H and Chayama K.

  Two patients treated with pegylated interferon/ribavirin/telaprevir triple therapy for recurrent hepatitis C after living donor liver transplantation.

  Hepatol Res. 2014; 44: 1259-1264.

• Ohishi W, Cologne JB, Fujiwara S, Suzuki G, Hayashi T, Niwa Y, Akahoshi M, Ueda K, Tsuge M and Chayama K.

  Serum interleukin-6 associated with hepatocellular carcinoma risk: a nested case-control study.

  Int J Cancer. 2014; 134: 154-163.

• Yukutake M, Sasaki T, Serikawa M, Minami T, Okazaki A, Ishigaki T, Ishii Y, Kosaka K, Mouri T, Yoshimi S, Shimizu A, Tsuboi T, Tanitame K and Chayama K.

  Timing of radiological improvement after steroid therapy in patients with autoimmune pancreatitis.

  Scand J Gastroenterol. 2014; 49: 727-733.

• Yukutake M, Sasaki T, Serikawa M, Minami T, Okazaki A, Ishigaki T, Fujimoto Y, Hatta Y, Kitamura S and Chayama K.

  The effect of respiratory-gated positron emission tomography/computed tomography in patients with pancreatic cancer.

  Hell J Nucl Med. 2014; 17: 31-36.

• Boda T, Ito M, Oka S, Kitamura Y, Numata N, Sanomura Y, Matsuo T, Tanaka S, Yoshihara M, Arihiro K and Chayama K.

  Characteristics of metachronous gastric tumors after endoscopic submucosal dissection for gastric intraepithelial neoplasms.

  Gastroenterol Res Pract. 2014; 2014: 863595

• Hyogo H, Chayama K and Yamagishi S.

  Nonalcoholic fatty liver disease and cardiovascular disease.

  Curr Pharm Des. 2014; 20: 2403-2411.

• Sakuma T, Nishikawa A, Kume S, Chayama K and Yamamoto T.

  Multiplex genome engineering in human cells using all-in-one CRISPR/Cas9 vector system.

  Sci Rep. 2014; 4: 5400.

• Watari I, Oka S, Tanaka S, Igawa A, Nakano M, Aoyama T, Yoshida S and Chayama K.

  Comparison of small-bowel mucosal injury between low-dose aspirin and non-aspirin non-steroidal anti-inflammatory drugs: a capsule endoscopy study.

  Digestion. 2014; 89: 225-231.

• Kawakami Y, Suzuki F, Karino Y, Toyota J, Kumada H and Chayama K.

  Telaprevir is effective given every 12 h at 750 mg with pegylated interferon-alpha2b and ribavirin to Japanese patients with HCV-1b IL28B rs8099917 TT.

  Antivir Ther. 2014; 19: 277-285.

• Mori N, Imamura M, Takaki S, Araki T, Hayes NC, Aisaka Y and Chayama K.

  Hepatitis C virus (HCV) reactivation caused by steroid therapy for dermatomyositis.

  Intern Med. 2014; 53 2689-2693.

• Minami T, Sasaki T, Serikawa M, Kamigaki M, Yukutake M, Ishigaki T, Ishii Y, Mouri T, Yoshimi S, Shimizu A, Tsuboi T, Kurihara K, Tatsukawa Y, Miyaki E and Chayama K.

  Occupational Radiation Exposure during Endoscopic Retrograde Cholangiopancreatography and Usefulness of Radiation Protective Curtains.

  Gastroenterol Res Pract. 2014; 2014: 926876.

• Shiraishi Y, Fujimoto A, Furuta M, Tanaka H, Chiba K, Boroevich KA, Abe T, Kawakami Y, Ueno M, Gotoh K, Ariizumi S, Shibuya T, Nakano K, Sasaki A, Maejima K, Kitada R, Hayami S, Shigekawa Y, Marubashi S, Yamada T, Kubo M, Ishikawa O, Aikata H, Arihiro K, Ohdan H, Yamamoto M, Yamaue H, Chayama K, Tsunoda T, Miyano S and Nakagawa H.

  Integrated analysis of whole genome and transcriptome sequencing reveals diverse transcriptomic aberrations driven by somatic genomic changes in liver cancers.

  PLoS One. 2014; 9: e114263.

• Miwata T, Hiyama T, Quach DT, Le HM, Hua HN, Oka S, Tanaka S, Arihiro K and Chayama K.

  Differences in K-ras and mitochondrial DNA mutations and microsatellite instability between colorectal cancers of Vietnamese and Japanese patients.

  BMC Gastroenterol. 2014; 14: 203.

• Murakami E, Imamura M, Hayes CN, Abe H, Hiraga N, Honda Y, Ono A, Kosaka K, Kawaoka T, Tsuge M, Aikata H, Takahashi S, Miki D, Ochi H, Matsui H, Kanai A, Inaba T, McPhee F and Chayama K.

  Ultradeep sequencing study of chronic hepatitis C virus genotype 1 infection in patients treated with daclatasvir, peginterferon, and ribavirin.

  Antimicrob Agents Chemother. 2014; 58: 2105-2112.

• Honda Y KY, Kan H, Fujino H, Fukuhara T, Naeshiro N, Miyaki D, Kawaoka T, Hiramatsu A, Tsuge N, Imamura M, Hyogo H, Aikata H, Chayama, K.

  A second attack of cholestasis associated with erythropoietic protoporphyria was successfully treated by plasma exchange and blood transfusion.

  Clinical Journal of Gastroenterology. 2014; 7: 333-337.