業績紹介

Achivement

2011年業績

• Onji K, Yoshida S, Tanaka S, Kawase R, Takemura Y, Oka S, Tamaki T, Raytchev B, Kaneda K, Yoshihara M and Chayama K.

  Quantitative analysis of colorectal lesions observed on magnified endoscopy images.

  J Gastroenterol. 2011; 46: 1382-1390.

• Matsuo T, Ito M, Takata S, Tanaka S, Yoshihara M and Chayama K.

  Low prevalence of Helicobacter pylori-negative gastric cancer among Japanese.

  Helicobacter. 2011; 16: 415-419.

• Kawaoka T, Aikata H, Miyaki D, Murakami E, Azakami T, Takaki S, Nagaoki Y, Hashimoto Y, Katamura Y, Hiramatsu A, Waki K, Hiraga N, Miki D, Tsuge M, Imamura M, Kawakami Y, Takahashi S, Ochi H, Tashiro H, Ohdan H and Chayama K.

  Eradication of hepatitis C virus genotype 1 after liver transplantation by interferon therapy before surgery: Report of three patients with analysis of interleukin-28 polymorphism, hepatitis C virus core region and interferon-sensitivity determining region.

  Hepatol Res. 2011; 41: 1126-1131.

• Kodama H, Aikata H, Murakami E, Miyaki D, Nagaoki Y, Hashimoto Y, Azakami T, Katamura Y, Kawaoka T, Takaki S, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Takahashi S, Ishikawa M, Kakizawa H, Awai K, Kenjo M, Nagata Y and Chayama K.

  Clinical outcome of esophageal varices after hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma with major portal vein tumor thrombus.

  Hepatol Res. 2011; 41: 1046-1056.

• Hanaoka R, Ueno Y, Tanaka S, Nagai K, Onitake T, Yoshioka K and Chayama K.

  The water-soluble extract from cultured medium of Ganoderma lucidum (Reishi) mycelia (Designated as MAK) ameliorates murine colitis induced by trinitrobenzene sulphonic acid.

  Scand J Immunol. 2011; 74: 454-462.

• Kobayashi K, Sasaki T, Serikawa M, Inoue M, Itsuki H and Chayama K.

  Assessment of trypsinogen-2 levels as an early diagnostic for post-endoscopic retrograde cholangiopancreatography pancreatitis.

  Pancreas. 2011; 40: 1206-1210.

• Yoneda M, Fujii H, Sumida Y, Hyogo H, Itoh Y, Ono M, Eguchi Y, Suzuki Y, Aoki N, Kanemasa K, Imajo K, Chayama K, Saibara T, Kawada N, Fujimoto K, Kohgo Y, Yoshikawa T, Okanoue T and Japan Study Group of Nonalcoholic Fatty Liver D.

  Platelet count for predicting fibrosis in nonalcoholic fatty liver disease.

  J Gastroenterol. 2011; 46: 1300-1306.

• Mbarek H, Ochi H, Urabe Y, Kumar V, Kubo M, Hosono N, Takahashi A, Kamatani Y, Miki D, Abe H, Tsunoda T, Kamatani N, Chayama K, Nakamura Y and Matsuda K.

  A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population.

  Hum Mol Genet. 2011; 20: 3884-3892.

• Kawaoka T, Aikata H, Takaki S, Hiramatsu A, Waki K, Hiraga N, Miki D, Tsuge M, Imamura M, Kawakami Y, Takahashi S, Ochi H, Tashiro H, Ohdan H and Chayama K.

  IL28B polymorphism may guide pegylated interferon plus ribavirin therapy even after curative treatment for hepatitis C virus-related hepatocellular carcinoma.

  J Viral Hepat. 2011; 18: e550-560.

• Shimomura T, Hiyama T, Oka S, Tanaka S, Yoshihara M, Shimamoto F and Chayama K.

  Frequent somatic mutations of mitochondrial DNA in traditional serrated adenomas but not in sessile serrated adenomas of the colorectum.

  J Gastroenterol Hepatol. 2011; 26: 1565-1569.

• Higashiyama M, Oka S, Tanaka S, Sanomura Y, Imagawa H, Shishido T, Yoshida S and Chayama K.

  Risk factors for bleeding after endoscopic submucosal dissection of gastric epithelial neoplasm.

  Dig Endosc. 2011; 23: 290-295.

• Hotta K, Kitamoto T, Kitamoto A, Mizusawa S, Matsuo T, Nakata Y, Hyogo H, Ochi H, Kamohara S, Miyatake N, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Masuzaki H, Ueno T, Chayama K, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Sakata T, Tanaka K, Matsuzawa Y, Nakao K and Sekine A.

  Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area.

  J Hum Genet. 2011; 56: 716-719.

• Yoshida K, Ohishi W, Nakashima E, Fujiwara S, Akahoshi M, Kasagi F, Chayama K, Hakoda M, Kyoizumi S, Nakachi K, Hayashi T and Kusunoki Y.

  Lymphocyte subset characterization associated with persistent hepatitis C virus infection and subsequent progression of liver fibrosis.

  Hum Immunol. 2011; 72: 821-826.

• Ohishi W and Chayama K.

  Prevention of hepatitis B virus reactivation in immunosuppressive therapy or chemotherapy.

  Clin Exp Nephrol. 2011; 15: 634-640.

• Hiraga N, Imamura M, Abe H, Hayes CN, Kono T, Onishi M, Tsuge M, Takahashi S, Ochi H, Iwao E, Kamiya N, Yamada I, Tateno C, Yoshizato K, Matsui H, Kanai A, Inaba T, Tanaka S and Chayama K.

  Rapid emergence of telaprevir resistant hepatitis C virus strain from wildtype clone in vivo.

  Hepatology. 2011; 54: 781-788.

• Hiraga N, Abe H, Imamura M, Tsuge M, Takahashi S, Hayes CN, Ochi H, Tateno C, Yoshizato K, Nakamura Y, Kamatani N and Chayama K.

  Impact of viral amino acid substitutions and host interleukin-28b polymorphism on replication and susceptibility to interferon of hepatitis C virus.

  Hepatology. 2011; 54: 764-771.

• Nagai K, Ueno Y, Tanaka S, Hayashi R, Onitake T, Hanaoka R, Wada Y and Chayama K.

  Intestinal Tuberculosis with Hoarseness as a Chief Complaint due to Mediastinal Lymphadenitis.

  Case Rep Gastroenterol. 2011; 5: 540-545.

• Abe H, Hayes CN, Ochi H, Tsuge M, Miki D, Hiraga N, Imamura M, Takahashi S, Kubo M, Nakamura Y, Kamatani N and Chayama K.

  Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state.

  J Med Virol. 2011; 83: 1597-1607.

• Kamigaki M, Sasaki T, Serikawa M, Inoue M, Kobayashi K, Itsuki H, Minami T, Yukutake M, Okazaki A, Ishigaki T, Ishii Y, Kosaka K and Chayama K.

  Statins induce apoptosis and inhibit proliferation in cholangiocarcinoma cells.

  Int J Oncol. 2011; 39: 561-568.

• Imagawa H, Oka S, Tanaka S, Noda I, Higashiyama M, Sanomura Y, Shishido T, Yoshida S and Chayama K.

  Improved detectability of small-bowel lesions via capsule endoscopy with computed virtual chromoendoscopy: a pilot study.

  Scand J Gastroenterol. 2011; 46: 1133-1137.

• Takamura A, Ito M, Imagawa S, Takata S, Tanaka S, Teixeira CR, Kamada T, Haruma K and Chayama K.

  Helicobacter pylori cagA polymorphism and gastric inflammation: an international comparison between Japanese and Brazilian patients.

  Scand J Gastroenterol. 2011; 46: 1051-1056.

• Miki D, Ochi H, Hayes CN, Abe H, Yoshima T, Aikata H, Ikeda K, Kumada H, Toyota J, Morizono T, Tsunoda T, Kubo M, Nakamura Y, Kamatani N and Chayama K.

  Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers.

  Nat Genet. 2011; 43: 797-800.

• Saeed M, Shiina M, Date T, Akazawa D, Watanabe N, Murayama A, Suzuki T, Watanabe H, Hiraga N, Imamura M, Chayama K, Choi Y, Krawczynski K, Liang TJ, Wakita T and Kato T.

  In vivo adaptation of hepatitis C virus in chimpanzees for efficient virus production and evasion of apoptosis.

  Hepatology. 2011; 54: 425-433.

• Tsuge M, Takahashi S, Hiraga N, Fujimoto Y, Zhang Y, Mitsui F, Abe H, Kawaoka T, Imamura M, Ochi H, Hayes CN and Chayama K.

  Effects of hepatitis B virus infection on the interferon response in immunodeficient human hepatocyte chimeric mice.

  J Infect Dis. 2011; 204: 224-228.

• Tashiro H, Aikata H, Waki K, Amano H, Oshita A, Kobayashi T, Tanimoto Y, Kuroda S, Tazawa H, Chayama K, Asahara T and Ohdan H.

  Treatment strategy for early hepatocellular carcinomas: comparison of radiofrequency ablation with or without transcatheter arterial chemoembolization and surgical resection.

  J Surg Oncol. 2011; 104: 3-9.

• Chayama K, Hayes CN, Abe H, Miki D, Ochi H, Karino Y, Toyota J, Nakamura Y, Kamatani N, Sezaki H, Kobayashi M, Akuta N, Suzuki F and Kumada H.

  IL28B but not ITPA polymorphism is predictive of response to pegylated interferon, ribavirin, and telaprevir triple therapy in patients with genotype 1 hepatitis C.

  J Infect Dis. 2011; 204: 84-93.

• Kohno H, Kouno H, Aimitsu S, Aisaka Y, Kitamoto M, Kawakami H and Chayama K.

  Impact of ribavirin dose reduction on the efficacy of pegylated interferon plus ribavirin combination therapy for elderly patients infected with genotype 1b and high viral loads.

  Hepatol Res. 2011; 41: 626-634.

• Wakita T, Suzuki T, Evans MJ, Shimotohno K, Chayama K, Matsuura Y, Hijikata M, Moriishi K, Seya T, Enomoto N, Koike K, Kato N, Kanto T and Hotta H.

  Will there be an HCV meeting in 2020? Summary of the 17th international meeting on hepatitis C virus and related viruses.

  Gastroenterology. 2011; 141: e1-5.

• Ozeki I, Akaike J, Karino Y, Arakawa T, Kuwata Y, Ohmura T, Sato T, Kamiya N, Yamada I, Chayama K, Kumada H and Toyota J.

  Antiviral effects of peginterferon alpha-2b and ribavirin following 24-week monotherapy of telaprevir in Japanese hepatitis C patients.

  J Gastroenterol. 2011; 46: 929-937.

• Abe H, Imamura M, Hiraga N, Tsuge M, Mitsui F, Kawaoka T, Takahashi S, Ochi H, Maekawa T, Hayes CN, Tateno C, Yoshizato K, Murakami S, Yamashita N, Matsuhira T, Asai K and Chayama K.

  ME3738 enhances the effect of interferon and inhibits hepatitis C virus replication both in vitro and in vivo.

  J Hepatol. 2011; 55: 11-18.

• Azakami T, Hayes CN, Sezaki H, Kobayashi M, Akuta N, Suzuki F, Kumada H, Abe H, Miki D, Tsuge M, Imamura M, Kawakami Y, Takahashi S, Ochi H, Nakamura Y, Kamatani N and Chayama K.

  Common genetic polymorphism of ITPA gene affects ribavirin-induced anemia and effect of peg-interferon plus ribavirin therapy.

  J Med Virol. 2011; 83: 1048-1057.

• Hashimoto Y, Ochi H, Abe H, Hayashida Y, Tsuge M, Mitsui F, Hiraga N, Imamura M, Takahashi S, Nelson Hayes C, Ohishi W, Kubo M, Tsunoda T, Kamatani N, Nakamura Y and Chayama K.

  Prediction of response to peginterferon-alfa-2b plus ribavirin therapy in Japanese patients infected with hepatitis C virus genotype 1b.

  J Med Virol. 2011; 83: 981-988.

• Nagaoki Y, Aikata H, Miyaki D, Murakami E, Hashimoto Y, Katamura Y, Azakami T, Kawaoka T, Takaki S, Hiramatsu A, Waki K, Imamura M, Kawakami Y, Takahashi S and Chayama K.

  Clinical features and prognosis in patients with hepatocellular carcinoma that developed after hepatitis C virus eradication with interferon therapy.

  J Gastroenterol. 2011; 46: 799-808.

• Abe H, Hayes CN, Ochi H, Maekawa T, Tsuge M, Miki D, Mitsui F, Hiraga N, Imamura M, Takahashi S, Kubo M, Nakamura Y and Chayama K.

  IL28 variation affects expression of interferon stimulated genes and peg-interferon and ribavirin therapy.

  J Hepatol. 2011; 54: 1094-1101.

• Kajiwara K, Kakizawa H, Takeuchi N, Toyota N, Hieda M, Ishikawa M, Tanitame K, Tani C, Suzuki T, Fujikawa K, Aikata H, Chayama K and Awai K.

  Cutaneous complications after transcatheter arterial treatment for hepatocellular carcinoma via the internal mammary artery: how to avoid this complication.

  Jpn J Radiol. 2011; 29: 307-315.

• Sumida T, Kitadai Y, Shinagawa K, Tanaka M, Kodama M, Ohnishi M, Ohara E, Tanaka S, Yasui W and Chayama K.

  Anti-stromal therapy with imatinib inhibits growth and metastasis of gastric carcinoma in an orthotopic nude mouse model.

  Int J Cancer. 2011; 128: 2050-2062.

• Oka S, Tanaka S, Takata S, Kanao H and Chayama K.

  Clinical usefulness of narrow band imaging magnifying classification for colorectal tumors based on both surface pattern and microvessel features.

  Dig Endosc. 2011; 23: S101-105.

• Ochi H, Maekawa T, Abe H, Hayashida Y, Nakano R, Imamura M, Hiraga N, Kawakami Y, Aimitsu S, Kao JH, Kubo M, Tsunoda T, Kumada H, Nakamura Y, Hayes CN and Chayama K.

  IL-28B predicts response to chronic hepatitis C therapy--fine-mapping and replication study in Asian populations.

  J Gen Virol. 2011; 92: 1071-1081.

• Ohara E, Hiraga N, Imamura M, Iwao E, Kamiya N, Yamada I, Kono T, Onishi M, Hirata D, Mitsui F, Kawaoka T, Tsuge M, Takahashi S, Abe H, Hayes CN, Ochi H, Tateno C, Yoshizato K, Tanaka S and Chayama K.

  Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice.

  J Hepatol. 2011; 54: 872-878.

• Ohishi W, Fujiwara S, Cologne JB, Suzuki G, Akahoshi M, Nishi N, Tsuge M and Chayama K.

  Impact of radiation and hepatitis virus infection on risk of hepatocellular carcinoma.

  Hepatology. 2011; 53: 1237-1245.

• Chayama K, Hayes CN, Yoshioka K, Moriwaki H, Okanoue T, Sakisaka S, Takehara T, Oketani M, Toyota J, Izumi N, Hiasa Y, Matsumoto A, Nomura H, Seike M, Ueno Y, Yotsuyanagi H and Kumada H.

  Factors predictive of sustained virological response following 72 weeks of combination therapy for genotype 1b hepatitis C.

  J Gastroenterol. 2011; 46: 545-555.

• Fujimoto Y, Ochi H, Maekawa T, Abe H, Hayes CN, Kumada H, Nakamura Y and Chayama K.

  A single nucleotide polymorphism in activated Cdc42 associated tyrosine kinase 1 influences the interferon therapy in hepatitis C patients.

  J Hepatol. 2011; 54: 629-639.

• Kuwabara T, Urabe Y, Hiyama T, Tanaka S, Shimomura T, Oko S, Yoshihara M and Chayama K.

  Prevalence and impact of musculoskeletal pain in Japanese gastrointestinal endoscopists: a controlled study.

  World J Gastroenterol. 2011; 17: 1488-1493.

• Tatsugami M, Ito M, Ishihara K, Haruma K, Sumii M, Sasaki A, Kitamura S, Takamura A, Wada Y, Matsumoto Y, Imagawa S, Takata S, Tanaka S, Yoshihara M and Chayama K.

  Plaunotol induces a comparative increase of acidic mucin fraction in gastric juice.

  Hepatogastroenterology. 2011; 58: 663-668.

• Inoue M, Tazuma S, Kanno K, Hyogo H, Igarashi K and Chayama K.

  Bach1 gene ablation reduces steatohepatitis in mouse MCD diet model.

  J Clin Biochem Nutr. 2011; 48: 161-166.

• Manabe N, Nakamura K, Hara M, Imamura H, Kusunoki H, Tanaka S, Chayama K, Hata J and Haruma K.

  Impaired gastric response to modified sham feeding in patients with postprandial distress syndrome.

  Neurogastroenterol Motil. 2011; 23: 215-219, e112.

• Kimura Y, Hyogo H, Ishitobi T, Nabeshima Y, Arihiro K and Chayama K.

  Postprandial insulin secretion pattern is associated with histological severity in non-alcoholic fatty liver disease patients without prior known diabetes mellitus.

  J Gastroenterol Hepatol. 2011; 26: 517-522.

• Doskali M, Tanaka Y, Ohira M, Ishiyama K, Tashiro H, Chayama K and Ohdan H.

  Possibility of adoptive immunotherapy with peripheral blood-derived CD3CD56+ and CD3+CD56+ cells for inducing antihepatocellular carcinoma and antihepatitis C virus activity.

  J Immunother. 2011; 34: 129-138.

• Kawaoka T, Hayes CN, Ohishi W, Ochi H, Maekawa T, Abe H, Tsuge M, Mitsui F, Hiraga N, Imamura M, Takahashi S, Kubo M, Tsunoda T, Nakamura Y, Kumada H and Chayama K.

  Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b.

  J Hepatol. 2011; 54: 408-414.

• Imagawa H, Oka S, Tanaka S, Noda I, Higashiyama M, Sanomura Y, Shishido T, Yoshida S and Chayama K.

  Improved visibility of lesions of the small intestine via capsule endoscopy with computed virtual chromoendoscopy.

  Gastrointest Endosc. 2011; 73: 299-306.

• Urabe Y, Hiyama T, Tanaka S, Yoshihara M, Arihiro K and Chayama K.

  Advantages of endoscopic submucosal dissection versus endoscopic oblique aspiration mucosectomy for superficial esophageal tumors.

  J Gastroenterol Hepatol. 2011; 26: 275-280.

• Kuwabara T, Hiyama T, Tanaka S, Yoshihara M, Arihiro K and Chayama K.

  Genetic pathways of multiple esophageal squamous cell carcinomas.

  Oncol Rep. 2011; 25: 453-459.

• Suzuki F, Suzuki Y, Akuta N, Sezaki H, Hirakawa M, Kawamura Y, Hosaka T, Kobayashi M, Saito S, Arase Y, Ikeda K, Kobayashi M, Chayama K, Kamatani N, Nakamura Y, Miyakawa Y and Kumada H.

  Influence of ITPA polymorphisms on decreases of hemoglobin during treatment with pegylated interferon, ribavirin, and telaprevir.

  Hepatology. 2011; 53: 415-421.

• Hayes CN, Kobayashi M, Akuta N, Suzuki F, Kumada H, Abe H, Miki D, Imamura M, Ochi H, Kamatani N, Nakamura Y and Chayama K.

  HCV substitutions and IL28B polymorphisms on outcome of peg-interferon plus ribavirin combination therapy.

  Gut. 2011; 60: 261-267.

• Sumida Y, Yoneda M, Hyogo H, Yamaguchi K, Ono M, Fujii H, Eguchi Y, Suzuki Y, Imai S, Kanemasa K, Fujita K, Chayama K, Yasui K, Saibara T, Kawada N, Fujimoto K, Kohgo Y, Okanoue T and Japan Study Group of Nonalcoholic Fatty Liver D.

  A simple clinical scoring system using ferritin, fasting insulin, and type IV collagen 7S for predicting steatohepatitis in nonalcoholic fatty liver disease.

  J Gastroenterol. 2011; 46: 257-268.

• Chayama K, Hayes CN, Hiraga N, Abe H, Tsuge M and Imamura M.

  Animal model for study of human hepatitis viruses.

  J Gastroenterol Hepatol. 2011; 26: 13-18.

• Yokosuka O, Kurosaki M, Imazeki F, Arase Y, Tanaka Y, Chayama K, Tanaka E, Kumada H, Izumi N, Mizokami M and Kudo M.

  Management of hepatitis B: Consensus of the Japan Society of Hepatology 2009.

  Hepatol Res. 2011; 41: 1-21.

• Chayama K and Hayes CN.

  Hepatitis C virus: How genetic variability affects pathobiology of disease.

  J Gastroenterol Hepatol. 2011; 26: S83-95.

• Tsuge M, Fujimoto Y, Hiraga N, Zhang Y, Ohnishi M, Kohno T, Abe H, Miki D, Imamura M, Takahashi S, Ochi H, Hayes CN, Miya F, Tsunoda T and Chayama K.

  Hepatitis C virus infection suppresses the interferon response in the liver of the human hepatocyte chimeric mouse.

  PLoS One. 2011; 6: e23856.

• Ushitora Y, Tashiro H, Takahashi S, Amano H, Oshita A, Kobayashi T, Chayama K and Ohdan H.

  Splenectomy in chronic hepatic disorders: portal vein thrombosis and improvement of liver function.

  Dig Surg. 2011; 28: 9-14.

• Oba S, Tanaka S, Sano Y, Oka S and Chayama K.

  Current status of narrow-band imaging magnifying colonoscopy for colorectal neoplasia in Japan.

  Digestion. 2011; 83: 167-172.

• Takayoshi Shishido SO, Shinji Tanaka, Taiki Aoyama, Ikue Watari, Hiroki Imagawa, Shigeto Yoshida, Toru Hiyama, Kazuaki Chayama.

  Removal of a sewing needle penetrating the wall of the third portion of the duodenum by double-balloon endoscopy.

  Clinical Journal of Gastroenterology. 2011; 5: 79-81.